The Impact of the Immune System on the Tumor Microenvironment: Relevance to Glioma Development
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 26
Special Issue Editor
Special Issue Information
Dear Colleagues,
Gliomas are the most common malignant primary brain tumors with a peak incidence in children and those aged 50 to 60 years. Brain tumors are characterized by high morbidity and mortality owing to their localization and often locally invasive growth, making current therapies only a temporary and limited solution. The tumor microenvironment is composed of immune cells, tumor cells, and surrounding stromal cells. The interaction between different cell types through cell-to-cell contact and soluble factors acts in autocrine and paracrine ways to modulate tumor growth. Although immune cells attempt to counteract tumor development, somatic mutations and epigenetic modifications of gliomas lead to the inhibition of local immune responses and even exploit immune cells and products to favor tumor growth. This microenvironment induces the suppression of NK cell activity, T-cell activation and proliferation, a shift of tumor-associated macrophages towards an M2 (immunosuppressive) phenotype, and the inhibition of dendritic cell maturation and function. This Special Issue will focus on original papers covering topics related to "Immune Microenvironment in Glioma" that present advances in those fields.
Dr. Gabriela Verónica Salamone
Guest Editor
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Keywords
- gliomas
- tumor microenvironment
- immune
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