Multifunctional Bioscaffolds for Biomedical Applications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 57
Special Issue Editors
Interests: tissue engineering; synthetic scaffolds; biologic scaffolds; biomaterials; stem cells; tissue regeneration
Special Issues, Collections and Topics in MDPI journals
Interests: tissue engineering; scaffolds; biomaterials; biomechanics; bioreactors; tissue regeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Tissue engineering strategies aim to mimic the anatomical structure of the native extracellular matrix (ECM) of damaged organs to stimulate their functional regeneration.
Multifunctional scaffolds can well accomplish this role, being designed to trigger tissue regrowth by providing biochemical cues, biomimetic patterns, bioactive agents, and proper mechanical features. Additionally, multifunctional bioscaffolds can be endowed with enhanced properties for cell interaction and tissue regeneration by acting as delivery platforms that convey to the site of injury antibacterial molecules to prevent infection, growth factors to induce direct cell differentiation, and anti-inflammatory agents to modulate inflammation.
This Special Issue focuses on some of the main features related to the manufacturing and characterization of multifunctional scaffolds for biomedical applications, including the combination of different polymers or synthetic/biologic materials, the fabrication of biological decellularized matrices, scaffold functionalization through bioactive agents (e.g., peptides, growth factors, and trophic factors), or through nanomaterials (e.g., carbon nanotubes and gold particles).
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- The standardization of advanced strategies for multifunctional bioscaffold production;
- The development of 3D-printed bioscaffolds with controlled geometry and biomimetic structures;
- The in vitro characterization of scaffold morphology and ultrastructure, also in comparison with the native anatomy of the tissue to be replaced;
- The biomechanical response of scaffolds under loading conditions that simulate in vivo mechanical stimuli (e.g., tensile or compressive strain, multiaxial loading, friction, and wear behavior);
- The investigation of scaffold cytotoxicity and cell–scaffold interactions;
- The development of bioreactors for the mechanical stimulation of scaffolds during cell culture;
- The in vivo assessment of scaffold biocompatibility and therapeutic potential by using animal models of organ/tissue damage;
- The application of multifunctional biomaterials in a clinical setting.
We look forward to receiving your contributions.
Dr. Silvia Barbon
Dr. Silvia Todros
Guest Editors
Manuscript Submission Information
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Keywords
- biomimetic scaffolds
- biomaterials
- functionalization
- biomechanics
- biocompatibility
- tissue regeneration
- tissue engineering
