Molecular Mechanisms in Mitochondria-Targeted Drug Delivery System
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 30 May 2025 | Viewed by 26
Special Issue Editors
Interests: mitochondria; lipidomics; drug release; oxidative stress; microplastics
Interests: mitochondria; oxidative stress; reactive oxygen species (ROS); cellular respiration; antioxidant defense
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria are essential organelles that play a crucial role in energy production, calcium homeostasis, and the regulation of apoptosis. Due to these vital functions, they serve as key therapeutic targets for a wide range of conditions, including cancer, neurodegenerative diseases, cardiovascular disorders, metabolic syndromes, and age-related ailments. Mitochondrial diseases, a group of disorders caused by dysfunctional mitochondria, often result from mutations in either mitochondrial DNA or nuclear DNA, which impair mitochondrial function. Developing effective treatments for mitochondrial diseases presents significant challenges, primarily due to the difficulty of delivering therapeutic agents specifically to the mitochondria. Drug delivery systems (DDSs) have been developed to address these challenges by efficiently transporting therapeutic agents, such as medications, to their intended cellular or subcellular targets. These systems aim to enhance drug efficacy, minimize side effects, and improve patient outcomes. Advances in DDS technology have the potential to transform the treatment of mitochondrial diseases, offering greater therapeutic precision and enhanced patient experiences. As a result, DDSs represent a promising strategy for tackling these complex challenges. With this Special Issue, we aim to highlight the latest advancements and ongoing research into the molecular mechanisms underlying mitochondrial drug delivery systems. We invite scientists from around the world to contribute their findings in the form of original research articles or comprehensive reviews. Your contributions are highly valued, and we look forward to showcasing your work.
Dr. Maria Manuel Oliveira
Dr. Francisco Peixoto
Guest Editors
Manuscript Submission Information
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Keywords
- mitochondria
- mitochondrial diseases
- nanoformulations
- therapeutic agents
- drug release
- precision medicine
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