Exploring Biological Mechanisms and Therapeutic Strategies for Substance Use Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 197
Special Issue Editor
Special Issue Information
Dear Colleagues,
Substance use disorders (SUDs) are multifactorial disorders of biopsychosocial etiology associated with structural and functional changes of the human brain leading to an impulsive/compulsive behavior. The neuroendocrine system mediates a wide range of responses and adaptations that help maintain homeostasis in stressful situations. An impaired regulation of this system has been proposed as a major contributing factor to substance abuse and recidivism in a wide range of drugs and substances. Considering the increasing rate of substance use among the global population, a future SUD epidemic might be expected. This provides the rationale for further characterizing the molecular mechanisms and abnormalities of SUDs, including the neuroendocrine dysfunctions and alterations, to help reveal risk factors and consequently develop efficient preventive and therapeutic strategies. In this Special Issue, papers exploring the complex biological mechanisms underlying substance use disorders (SUDs) and the development of innovative therapeutic strategies are included, particularly delving into the neurobiological mechanisms of how physical exercise impacts SUDs.
Dr. Thomas Paparrigopoulos
Guest Editor
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Keywords
- addiction
- alcohol use disorder
- opioid use disorder
- substance use disorders
- physical exercise
- physical activity
- molecular mechanisms
- neuroendocrine system
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