Molecular Research on Chronic Kidney Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 123
Special Issue Editor
Special Issue Information
Dear Colleagues,
Chronic kidney disease (CKD) is a progressive condition characterized by the gradual loss of kidney function, leading to systemic complications, such as cardiovascular disease (CVD) and mineral bone disorder (CKD-MBD), which are associated with high mortality rates. Traditional risk factors cannot fully explain the high incidence of fatal CVD events in CKD. In CKD, cardiovascular complications are influenced by hypertension, hyperlipidemia, and inflammation, with molecular mechanisms, such as RAAS activation, oxidative stress, and endothelial dysfunction, playing key roles.
Mineral and bone disorders (MBDs) are common in CKD, and emerging evidence indicates a causal relationship between MBD and CVD through mechanisms such as vascular calcification and fibrosis. Thus, understanding the prognostic importance of bone and mineral parameters regarding cardiovascular outcomes and mortality is attracting increasing interest. Molecular research has been pivotal in unraveling the underlying mechanisms driving these complications, aiming to develop effective therapies.
Further, the complex interplay between the kidneys, bones, and heart in kidney dysfunction involves hemodynamic, neurohormonal, and immunological pathways. Future molecular genetic research, including genomic, epigenetic, transcriptomic, and proteomic studies, holds promise for identifying new therapeutic targets and personalized treatment strategies.
This Special Issue aims to explore these molecular mechanisms and potential interventions, offering insights into improving patient outcomes for CKD and its complications.
Dr. Sohel Julovi
Guest Editor
Manuscript Submission Information
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Keywords
- CKD
- CVD
- CKD-MBD
- oxidative stress
- inflammation
- fibrosis
- biochemical markers
