Recent Research in Metabolism and Its Effects on Cardiac Health
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 275
Special Issue Editor
2. Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan
3. Clinical Metabolomics Core Laboratory, Chang Gung Memorial Hospital at Linkou, Taoyuan City 33302, Taiwan
4. Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan City 33302, Taiwan
5. Healthy Aging Research Center, Chang Gung University, Taoyuan City 33302, Taiwan
Interests: antioxidants; oxidative stress; viral infection; enterovirus; metabolomics; natural compounds; biochemistry
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Special Issue Information
Dear Colleagues,
Metabolism is essential to normal cardiac functions. Highly efficient mitochondrial ATP generation is required to sustain continual contraction. An important feature of heart is metabolic flexibility, which allows the myocardium to adapt to utilization of various energy sources, such as glucose, free fatty acids, amino acids, lactate and ketones, so as to meet the its metabolic needs. An intricate network of metabolic pathways and the regulatory elements are involved in such metabolic adaptation or reprogramming processes. Any disruption of these processes can lead to histopathological and functional changes associated with cardiac pathology. In the case of heart failure, metabolic inflexibility, energetic deficit, and oxidative stress are associated with the maladaptive cardiac remodeling and dysfunction. Signal transduction, transcriptional and non-coding RNA/microRNA regulation networks are responsive to metabolic state of cardiac cells. Advanced system biology technologies, such as metabolomics, transcriptomics, proteomics, microRNA omics, and multi-omics approach greatly help us delineate these molecular networks. Understanding these molecular control processes open an avenue to identify novel therapeutic targets. Intervention measures to modify substrate utilization and to manage oxidative stress in mitochondria may have promising cardioprotective effect. This is particularly important as more than half a billion individuals suffer from cardiovascular diseases, and the number of deaths from cardiovascular diseases amounts to about one-third of all global deaths. Any contribution to research on cardiovascular biology and medicine is essentially life-saving.
The editor of this Special Issue invites researchers in the field of cardiology to submit original research articles and review articles on these topics.
Dr. Hung-Yao Ho
Guest Editor
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Keywords
- cardiology
- cardiovascular diseases
- heart failure
- cardiac remodeling
- ischemia
- reperfusion
- metabolism
- energy metabolism
- metabolomics
- transcriptomics
- microRNA
- non-coding RNA
- oxidative stress
- mitochondria
- beta-blockers
- calcium-channel blockers
- anti-arrhythmic medicine
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