Sigma-1 Receptor: Signaling, Functions and Therapeutic Potential
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 45
Special Issue Editors
Interests: blood-brain barrier permeability; Sigma-1R; calcium signaling; cardiovascular regulation; GPCR signaling; second messenger signaling
Special Issue Information
Dear Colleagues,
You are invited to contribute to the Special Issue of IJMS entitled “Sigma-1 Receptor: Signaling, Functions and Therapeutic Potential”.
Sigma 1R, a non-opioid intracellular receptor located on the endoplasmic reticulum, binds a variety of ligands, the majority of which are amines. Synthetic Sigma-1R agonists include antidepressants (e.g., fluvoxamine), antipsychotics (e.g., haloperidol), and drugs of abuse (e.g., cocaine, methamphetamine). The endogenous Sigma-1R agonist remained elusive. In the last 15 years, amines such as dimethyl tryptamine (DMT) and choline, neurosteroids, and bioactive sphingolipids were reported to act as endogenous Sigma-1R agonists. Sigma-1R has complex signaling mechanisms and a wide variety of physiological and pathophysiological roles.
This Special Issue of IJMS is intended to provide a comprehensive synopsis of current research on Sigma-1R signaling, cellular and molecular mechanisms, physiologic roles, regulation, and therapeutic potential. Submissions of original research, including in vitro and in vivo studies and comprehensive review articles related to any of these aspects, are invited.
Prof. Dr. Gabriela Cristina Brailoiu
Dr. Eugen Brailoiu
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Sigma-1R
- intracellular receptor
- molecular mechanisms
- calcium signaling
- neurological diseases
- neurodegenerative diseases
- pain
- cancer
- addiction
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