Molecular Insights in Diabetes
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 25 December 2025 | Viewed by 84
Special Issue Editors
Interests: lipid metabolism; familial hypercholesterolemia; inherited dyslipidemias; atherosclerosis; non-lipid effects of lipid lowering treatment; obesity; diabetes; adipokine; hepatokine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Type 2 diabetes is characterised by a complex pathophysiology involving impaired insulin action, beta-cell dysfunction, and increased oxidative stress. There is extensive scientific evidence demonstrating that impaired insulin signalling leads to impaired glucose uptake and insulin resistance. Furthermore, inflammatory pathways and oxidative damage exacerbate insulin resistance, contributing to the development of microvascular and cardiovascular complications. Epigenetic changes, such as DNA methylation and histone modifications, can cause long-term shifts in gene expression, even after glycaemic control is achieved—a phenomenon known as 'metabolic memory'. Additionally, microRNAs and other non-coding RNAs play a pivotal role in maintaining beta-cell function, and their dysregulation has been associated with disease progression. The therapeutic use of gut-derived hormones (including incretins such as GLP-1 and GIP) that target these pathways offers a novel means of restoring glucose homeostasis. This Special Issue invites original research and reviews focusing on molecular mechanisms, regulatory RNAs, epigenetic memory, and innovative therapies. We welcome contributions that explore how emerging science can improve treatment outcomes and expand our understanding of the pathophysiology of type 2 diabetes.
Dr. Mariann Harangi
Dr. Ferenc Sztanek
Guest Editors
Manuscript Submission Information
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Keywords
- insulin signalling pathway
- pancreatic beta-cell dysfunction
- oxidative stress
- epigenetic modifications
- metabolic memory
- small regulatory RNAs (miRNAs)
- inflammation and insulin resistance
- glucagon-like peptide-1 (GLP-1)
- glucose-dependent insulinotropic polypeptide (GIP)
- molecular therapeutic targets
- glucose homeostasis regulation
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