Advances in Gynecological Cancers—3rd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 18
Special Issue Editor
Interests: ovarian cancer; personalized medicine; DNA damage response; DNA repair mechanisms; uterine cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
New insights into the underlying biology of gynecological cancers, revealed by studying gene expression profiles, have unequivocally improved their clinical management. Maintenance therapy with poly(ADP- ribose) polymerase inhibitors (PARPi) and/or bevacizumab for high-grade serous ovarian cancer patients, responding to platinum-based chemotherapy, represents an excellent example of targeted therapy successfully translated into the daily clinical oncology practice. Notwithstanding the good initial responses, both the inevitable tumor’s clonal evolution and the ultimate resistance emergence indicate an arguable hindrance to these novel therapies, resulting in disease relapse. At present, the efficacy of subsequent treatment strategies is diminished, whereas immunotherapy has not yet provided a clinical benefit.
On the other hand, for patients with recurrent or metastatic endometrial and cervical cancer, immune checkpoint inhibitors (ICIs) represent an emerging treatment option with promising durability. Furthermore, several ongoing trials featuring immune checkpoint blockade explore its potential in the adjuvant and neoadjuvant setting. The identification of predictive biomarkers along with an in-depth understanding of molecular mechanisms behind both treatment response and resistance are of paramount importance.
This Special Issue of the International Journal of Molecular Sciences aims to highlight important advances in gynecological cancer patients’ management over the past decade as well as future challenges, with regard to tailored, personalized treatment guidance for these patients, in the decades to come.
Dr. Michalis Liontos
Guest Editor
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Keywords
- ovarian cancer
- DNA damage repair (DDR) pathways
- PARP inhibitors
- endometrial cancer
- cervical cancer
- immunotherapy
- biomarkers
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