A Commemorative Issue in Honor of Professor Peter A. Ward: World Expert in Sepsis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 182
Special Issue Editor
Interests: sepsis; regulation of the inflammatory response; cytokines; chemokines; anti-inflammatory interleukins; complement factors; endogenous protease inhibitors; histones
Special Issue Information
Dear Colleagues,
Sepsis has long been a scourge in human medicine. At least 1.7 million adults in the U.S. develop sepsis annually, resulting in nearly 350,000 deaths, with sepsis being especially prevalent among adults aged over 60. In elderly humans with sepsis, there is a strong activation of complement factors and release of histones from neutrophils (PMNs) and macrophages (MФs) that are strongly proinflammatory. Dr. Peter Ward has spent nearly 50 years in active research related to leukocytes, neutrophils, macrophages, histones, and their roles in sepsis and inflammatory disorders. Much is known about how both PMNs and MФs are affected by complement activation products, resulting in a series of events that cause proinflammatory responses in cells and organs. Activated histones may undergo chemical modifications such as methylation, acetylation, etc., enhancing the biological proinflammatory activities of histones. These chemical responses may enhance or inhibit the functions of histones and inflammation. Currently, there are between 12 and 60 histones known to be related to PMNs and MФs, implying that research into the functions of activated histones is needed. Clearly, methods need to be developed to precisely define how histones perform in the setting of sepsis.
The scope of this Special Issue focuses on sepsis, which is an inflammatory response in PMNs and MФs and results in extensive cell and organ damage. Cell and organ injury may result from a destructive inflammatory response that is especially lethal in elderly humans. Although we know that histones can cause intense inflammatory responses, currently, there are no approved drugs that can neutralize histones or histone products.
Prof. Dr. Peter Ward
Guest Editor
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Keywords
- sepsis
- neutrophils
- macrophages
- histones
- chemical modifications
- apoptosis
- complement factors
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