The Role of Antibodies in Neurological Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 December 2024 | Viewed by 82
Special Issue Editor
2. Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, 4056 Basel, Switzerland
Interests: nervous system disease
Special Issue Information
Dear Colleagues,
There is an increased recognition of the role of B cells and autoantibodies in the pathogenesis of a number of diseases of the central and peripheral nervous system and the neuromuscular junction. The mechanisms behind the immune system developing nervous-system-specific B-cell and antibody-mediated autoimmunity, as well as the immune mechanisms implicated in antibody-associated pathology, are poorly understood. The aim of this Special Issue is to explore both the clinical features and the pathophysiological aspects of antibody-mediated neurological syndromes, as well as diseases such as multiple sclerosis, where the role of autoantibodies is still debated. Specifically, we are interested in gathering evidence of mechanisms related to the development of antibody-mediated autoimmunity, including molecular mimicry, cross-reactivity with self- or tumor-associated antigens, and the role of preceding and/or chronic latent infections. There will be a special focus on applying novel strategies to the identification of antibody targets. Finally, we are interested in collecting evidence on the specific mechanisms by which self-reactive antibodies may induce nervous system pathologies.
Dr. Ilaria Callegari
Guest Editor
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Keywords
- surface antigens
- antibodies
- neuroimmunology
- encephalitis
- nodopathies
- multiple sclerosis
- myasthenia gravis
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