Insights into Neurological and Psychiatric Diseases from Drosophila Models
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 50
Special Issue Editor
Interests: mechanisms of associative and nonassciative learning and memory; Drosophila and mouse models of intelectual disability; neurological and psychiatric conditions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The plethora of data produced by omics and GWAS studies of patients with neurological and psychiatric diseases needs experimental validation and mechanistic investigation. This includes but is not limited to the determination of the potential effects of GWAS-identified polymorphisms on the expression of proximal gene(s) and linking these effects to disease manifestations. Changes in the gene expression levels, or the abundance of proteins or molecular interactions identified using various omics approaches need to be tested experimentally and placed in the context of disease manifestations. Moreover, the genetic underpinnings of numerous neurological and psychiatric conditions still remain unclear and in need of a versatile genetic model to expediently test predictions and hypotheses stemming from patient genomic data. Over a century of Drosophila research has resulted in a powerful genetic model that offers unsurpassed genetic and molecular tools, expedience, and a rich and expandable repertoire of behaviors that can be used or adapted to model specific aspects and manifestations of neurological and psychiatric conditions.
This Special Issue will collect experimental research contributions and reviews on the development and use of Drosophila models of neurological and psychiatric conditions, the validation of GWAS hits and omics linkages, genetic and molecular explorations of disease mechanisms, and potential ameliorative approaches.
Prof. Dr. Efthimios M. C. Skoulakis
Guest Editor
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Keywords
- disease model development
- disease model validation
- GWAS validation
- ameliorative approaches
- pharmacogenetics
- pharmacoproteomics
- disease mechanisms
- suppressor/enhancer genetic screens
- synthetic lethality screens
- biomarker screens and validation
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