New Targeted Therapies in Cancer: 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 178
Special Issue Editor
Interests: colorectal cancer; targeted therapy; personalized medicine; preclinical research models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Finding useful therapeutic solutions to fight cancer is a clinical need. The conventional chemotherapeutic approaches are effective in different tumor settings, but often cause important side effects that strongly impair the patients’ quality of life. The idea of targeted therapy—targeting a specific genetic alteration, present in the tumor but not in normal tissues—is strongly improving the standard-of-care of many cancers (e.g., leukemia, colorectal, gastric, mammary): targeted therapies, in fact, specifically block cancer cells proliferation, decreasing the risk of treatment-associated off-target effects.
Different molecular targets have been explored, such as growth factors, cell surface molecules and receptors, but also non-coding RNAs and entire signaling pathways. Molecules targeting BCR-ABL, BRAF, MEK, EGFR, ALK are few examples of targeted therapies that showed important results in cancer patients. However, depending the effectiveness on the presence of the altered target, the number of patients taking advantage from these treatments is limited. In addition, low response and resistance to targeted drugs have been documented, together with unexpected side effects. Just few molecules among hundreds of potential drug candidates reach the market, therefore further investigation is warranted.
Nowadays, the huge progresses of technological tools allow a deep investigation of tumor heterogeneity and clonality, essential in determining the success of targeted therapies. This Special Issue is aimed to highlight recent discoveries in the field of New Targeted Therapies in Cancer, concerning different kind of molecules, alternative therapeutic strategies and novel targets.
Dr. Rosaria Chilà
Guest Editor
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Keywords
- targeted therapy
- personalized medicine
- side effects
- molecular targets
- cancer treatment
- mutations
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