Shaping Macrophages Polarization as an Emerging Therapeutic Approach
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 57
Special Issue Editor
Interests: medicinal chemistry; synthesis and biological evaluation of new small molecules for the therapy of cancer; inflammatory diseases and infections; extraction of bioactive compounds from natural sources
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Macrophages play a crucial role in maintaining homeostasis and defending against pathogens. Their ability to adopt different functional states, known as polarization, makes them key players in various physiological and pathological processes. Harnessing the ability to shape macrophage polarization holds promising therapeutic potential for a wide range of diseases, including cancer, chronic inflammation, and autoimmune disorders. Several strategies are being explored to influence macrophage polarization, including the use of cytokines, small molecules, and nanoparticles. Small molecules and drugs can also be designed to target specific signaling pathways involved in macrophage polarization. Despite the promising potential, several challenges remain in translating macrophage polarization modulation into clinical therapies. Further research is necessary to understand the detailed mechanisms of macrophage polarization and to develop more precise and effective methods for their modulation. In this special issue we will focus on molecular studies unravelling the detailed mechanisms of macrophage polarization, as well as on innovative strategies for macrophages plasticity modulation and on their use in specific disease conditions, including drug resistance. Original research articles and reviews will be considered for publication.
Dr. Cristina Maccallini
Guest Editor
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Keywords
- macrophage polarization
- M1 macrophages
- M2 macrophages
- immune modulation
- small molecules
- therapeutic strategies
- inflammation
- cancer immunotherapy
- drug resistance
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