Drug Discovery and Development for Renal Disease Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 13
Special Issue Editor
Interests: renal physiology; diabetic kidney disease; acute kidney injury; chronic kidney disease; proteinuria; hypertension; renal and renovascular hypertension; renal renin angiotensin system
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
So far, drug discovery has undergone a major transformation, progressing from the recognition and refinement of natural products with therapeutic benefits to the systematic screening of molecular libraries on whole organisms or cell lines. Recently, a more target-based approach driven by greater knowledge of the physiological and pathological pathways involved has been focused. A novel target is derived from various sources: clinical research, structural biology, application of in silico methodologies, computational-based toxicology, and advanced manufacturing approaches.
Once a target has been validated, numerous processes must be carried out to identify molecules with suitable characteristics to make acceptable drug candidates for clinical studies.
Looking to the future, investment in renal drug development must continue to cover the whole translational spectrum (from ‘bench to bedside and back again’) with the recognition that both biological discovery and clinical understanding will drive drug discovery, providing safe and effective therapies for renal disease.
This Special Issue aims to present current efforts in medicinal chemistry and early drug discovery. Original research articles, review articles, and short communications within (but not limited to) the research areas described are welcome.
Dr. Keiko Hosohata
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- kidney disease
- medicinal chemistry
- drug discovery
- computer-assisted drug design
- drug targets
- in vitro assays
- epigenetic targets
- multi-targeting compounds
- biophysical methods
- target engagement studies
