The Role of Epigenetics in Genome Maintenance and Its Relationship to Organismal Aging and Age-Related Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 32
Special Issue Editors
2. Chromatin Biology Laboratory, Josep Carreras Leukaemia Research Institute (IJC), Ctra de Can Ruti, Camí de les Escoles s/n, 08916 Badalona, Barcelona, Spain
Interests: genome integrity; chromatin; epigenetics; aging; meiosis; differentiation; cancer; neurodegeneration; inflammation
Special Issue Information
Dear Colleagues,
The maintenance of genome integrity is an intricate process involving the coordination of DNA repair, replication, transcription, and chromosome segregation pathways. These processes occur within the immensely complex environment of chromatin and require the action of multiple epigenetic factors. Despite the importance of chromatin regulation in maintaining genome integrity, researchers do not fully understand the mechanisms of action and their contributions to human diseases.
Chromatin regulation is particularly crucial in the context of aging. Epigenetic signatures, such as DNA methylation, histone modifications, and chromatin remodeling, undergo various changes as organisms age. These changes impact genome stability with significant consequences for human health, including a decline in reproductive capabilities and the appearance of age-related diseases such as cancer, neurodegeneration, and inflammatory conditions. Importantly, there is great clinical interest in targeting epigenetic proteins as they can reverse abnormal epigenetic information and restore genome function.
In this Special Issue, we invite researchers to present original studies and state-of-the-art reviews on epigenetic mechanisms. By discussing their data and opinions, researchers can provide valuable insights into the complex interactions between chromatin dynamics, genome integrity, aging, and disease.
Dr. Berta Vázquez
Dr. Gerardo Ferrer
Guest Editors
Manuscript Submission Information
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Keywords
- chromatin
- DNA damage
- DNA repair
- gene transcription
- DNA replication
- chromosome segregation
- genome integrity
- chromosome organization
