Neuroinflammation in Neurological Acute Critical Injuries
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 55
Special Issue Editor
Interests: neuroinflammation; pathophysiology of secondary brain damage (SAH, brain injury); intrathecal antibiotics; osteointegration and biological activity of material for arthrodesis
Special Issue Information
Dear Colleagues,
The neuroinflammatory response to major cerebral injuries such as subarachnoid hemorrhage, intracerebral hemorrhage, traumatic brain lesions, or meningitis remains one of the most important and interesting aspects related to the occurrence of secondary and delayed cerebral damage. A better understanding of pathophysiological ways, involved mediators, and the sequence and timing of events remains actual and interesting as it can provide therapeutic targets and strategies. In particular, a better definition of early trigger roles of cytokines, chemokines, leucocytes, and their migration into the subarachnoid and perivascular spaces may provide indications for the use of target drugs potentially useful in reducing vasospasms, oxidative stress, and blood–brain barrier disruption. In addition to specific drugs such as the endothelin receptor antagonist clazosentan, agents with pleiotropic effects could be particularly interesting. The occurrence of primary cerebrospinal fluid compartmental events presents particular interest. Studies in this field are requested by clinical practice to improve patients’ outcomes. We hope for an interest in and contribution to the realization of this Special Issue.
Dr. Fulvio Alberto Tartara
Guest Editor
Manuscript Submission Information
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Keywords
- neuroinflammation
- leucocyte rolling
- interleukins
- oxidative stress
- chemokines
- blood–brain barrier disruption
- subarachnoid hemorrhage
- intracerebral hemorrhage
- meningitis
- traumatic brain injury
