Molecular Mechanisms of Reproductive and Developmental Toxicology 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: closed (10 May 2024)
Special Issue Editor
Interests: reproductive and developmental toxicology; neurotoxicology; endocrine disruptors; risk assessment; molecular biology; in vitro and ex vivo studies; sex- and gender-specific exposure effects; transcriptomics; proteomics; bioinformatics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent decades, a growing body of evidence has raised concerns over the potential impact of the exposure to chemical compounds (especially endocrine-disrupting chemicals) on human health in association with an increased incidence of chronic diseases, including obesity, neurodegenerative disorders, fertility decline, etc. During everyday life, the general population is exposed to a cocktail of compounds, with their environment and diet as the main sources of exposure. Many of these chemicals may pass through the placental barrier, potentially inducing developmental disorders with long-lasting consequences. Indeed, pregnancy represents the most sensitive window of exposure since subtle stressor effects may also impact correct fetus development; in addition, the placenta may also be affected, which has consequences for the mother’s health. According to the Developmental Origins of Health and Disease hypothesis, exposure to chemicals experienced during intrauterine life may lead to adverse outcomes observed in puberty and adulthood. Thus, it is vital to investigate the mechanism by which single compounds and mixtures of chemicals may impair embryo/fetal development and how such effects are associated with the chronic diseases affecting millions of people worldwide in their adult lives. Furthermore, it is necessary to elucidate the toxicological mechanisms leading to reproductive disorders affecting the timing of puberty, sexual maturation, and fertility competence, among others. In this context, this Special Issue aims to provide an overview of the advances in reproductive and developmental toxicology with a special focus on the molecular mechanisms underlying the modes of action of various toxicants. Both research articles and reviews summarizing the state of the art are welcome. Potential topics include, but are not limited to, the following:
- mechanism-based reproductive and developmental toxicity studies applying new in vitro/in silico methodologies or zebrafish models;
- studies applying one or more omics approaches for the identification of relevant biomarkers of developmental toxicity;
- or a combination of in vitro/in vivo studies to link molecular modes of action to adverse outcomes representative of chronic diseases in animal models.
Dr. Sabrina Tait
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- reproductive toxicology
- developmental toxicology
- mode of action
- mechanism-based evidence
- chronic diseases
- organ-on-a-chip
- new approach methodologies
