Molecular Perspectives on Female Infertility and Fertility
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 24
Special Issue Editor
Interests: infertility; regeneration; stem cells; endocrine; gynecology; fertility; aging
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Female infertility is a major global health challenge, affecting millions of women of reproductive age and impacting 8–12% of couples worldwide. Infertility is a complex, multifactorial condition that arises from genetic, epigenetic, hormonal, metabolic, immunological, and environmental influences. At the same time, recent advances in molecular biology and reproductive medicine have created unprecedented opportunities to improve diagnostics, therapeutics, and preventive strategies for infertility and subfertility.
This Special Issue, Molecular Perspectives on Female Infertility and Fertility, aims to bring together high-quality contributions that deepen our understanding of the molecular mechanisms regulating female reproductive health, fertility preservation, and infertility pathogenesis. By fostering multidisciplinary research, this collection seeks to accelerate translational progress from bench to bedside and to inform innovative approaches for diagnosis, treatment, and personalized medicine.
We welcome original research articles, reviews, and short communications covering (but not limited to) the following topics:
- Molecular and cellular mechanisms of oocyte development, maturation, and competence;
- Genetic, epigenetic, and transcriptomic regulation of female fertility and infertility;
- Hormonal signaling pathways and endocrine regulation in reproductive health;
- Oxidative stress, mitochondrial dysfunction, and metabolic reprogramming in infertility;
- Molecular basis of gynecologic disorders affecting fertility (e.g., PCOS, endometriosis, premature ovarian insufficiency, ovarian failure);
- Inflammatory and immune-related mechanisms in reproductive dysfunction;
- DNA damage, genome integrity, and reproductive aging;
- Molecular biomarkers for oocyte quality, embryo viability, and clinical outcomes;
- Experimental and translational models for studying female infertility;
- MicroRNAs, non-coding RNAs, and molecular diagnostics in reproductive medicine;
- Stem cell biology, regenerative approaches, and bioengineering for fertility restoration;
- Novel therapeutic strategies, including pharmacological, nutraceutical, gene therapy, and precision medicine approaches.
If you are engaged in molecular, cellular, or translational research on female infertility and fertility, we warmly invite you to contribute to this Special Issue. Your work will help advance scientific knowledge and shape the future of women’s reproductive health worldwide.
Prof. Dr. Seung-Yup Ku
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- female infertility
- molecular mechanisms of reproduction
- oocyte maturation and development
- reproductive aging
- polycystic ovary syndrome
- endometriosis
- epigenetic regulation in reproduction
- oxidative stress and mitochondrial dysfunction
- reproductive biomarkers
- precision medicine and regenerative therapies
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