CRISPR-Cas Systems and Genome Editing-2.0

Dear Colleagues,

Almost everyone has heard of CRISPR/Cas systems. The use of CRISPR/Cas systems as RNA-programmable site-directed nucleases has given a powerful impulse to the further development of genome editing technology. Moreover, numerous modifications of CRISPR/Cas systems have enabled the development of principally new methods for genome engineering. New molecular tools have also become widespread in other areas of science, biotechnology and biomedicine. The emergence of such versatile, relatively easy-to-use and effective molecular tools has increased human hope for effective treatment of hereditary, bacterial, or viral diseases. However, CRISPR/Cas systems have a number of drawbacks that limit their application in therapeutic approaches. Thus, research to find new genome editors, modify existing genome editing technologies, and study the universe of defense mechanisms of prokaryotes may lead to the development of fundamentally new approaches to genome editing. This special issue aims to cover all areas of both basic research on CRISPR/Cas and other genome editing systems and their applications in basic science, biotechnology, and biomedicine. It welcomes original research, theoretical articles, reviews, and communications in which CRISPR/Cas or other genome editing technologies are a major topic or tool for mechanistic molecular research. This includes, but is not limited to, methodological advances in genome editing technologies and their applications to the study and treatment of hereditary, bacterial or viral human diseases, the development of new microbial producents, cultivated plant lines and fungi.

Please note that, for IJMS’s paper, theoretical studies should offer new insights into the understanding of experimental results or suggest new experimentally testable hypotheses.

Dr. Dmitry Karpov
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• prokaryotic defense systems with genome editing potential (CRISPR/Cas, bacterial argonauts, etc.)
• development or improvement of genome editing tools
• genome editing technologies in the generation and study of cellular, multicellular or animal models of hereditary, bacterial, or viral human diseases
• CRISPR/Cas systems in the therapy of human diseases
• genome editing to probe biotechnological processes and improve microbial producents, cultivated plants, and fungi