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Insects
Special Issues
The Insect Gut Barrier
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The Insect Gut Barrier

A special issue of Insects (ISSN 2075-4450). This special issue belongs to the section "Insect Physiology, Reproduction and Development".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 2890

Special Issue Editor

Dr. Gabrieli Paolo

E-Mail Website
Guest Editor
Department of Biosciences, Università degli Studi di Milano, 20122 Milan, Italy
Interests: mosquito; infection; vector biology and ecology

Special Issue Information

Dear Colleagues,

The guts of both adult and juvenile insects are the place for food digestion and nutrient absorption, but it also forms an important barrier against pathogen and microbe invasion. All these processes are regulated in a tight manner and alteration in the gut integrity might have serious, even lethal consequences. Dysbiosis, pathogen invasion and the presence of bacterial toxins are some of the biological phenomena that can cause the gut to malfunction and that can help us to better understand the biology of this organ at cellular and molecular levels. A comprehensive understanding of gut biology is, therefore, fundamental, especially in vectors of human and animal pathogens.

Dr. Paolo Gabrieli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Insects is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • insect gut
  • dysbiosis
  • pathogens
  • bacteria toxins
  • peritrophic matrix
  • food digestion

Published Papers (1 paper)

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Research

9 pages, 1639 KiB  
Article
The Increased Abundance of Commensal Microbes Decreases Drosophila melanogaster Lifespan through an Age-Related Intestinal Barrier Dysfunction
by Hye-Yeon Lee, Shin-Hae Lee and Kyung-Jin Min
Insects 2022, 13(2), 219; https://doi.org/10.3390/insects13020219 - 21 Feb 2022
Cited by 6 | Viewed by 2320
Abstract
Background: Commensal microbiota live in their host with a symbiotic relationship that affects the host’s health and physiology. Many studies showed that microbial load and composition were changed by aging and observed that increasing the abundance and changing the composition of commensal microbes [...] Read more.
Background: Commensal microbiota live in their host with a symbiotic relationship that affects the host’s health and physiology. Many studies showed that microbial load and composition were changed by aging and observed that increasing the abundance and changing the composition of commensal microbes had detrimental effects on host lifespan. We hypothesized that dysbiosis of the intestinal microbiota leads to systemic effects in aging flies as a result of the increased intestinal permeability. Methods: We used the fruit fly, Drosophila melanogaster, laboratory strains w1118, as a model system with many advantages for microbe–host studies. Results: The incidence of intestinal dysfunction was increased with age, and intestinal dysfunction increased the permeability of the fly intestine to resident microbes. The lifespan of flies with an intestinal barrier dysfunction was increased by removal of the microbes. Interestingly, some bacteria were also found in the hemolymph of flies with intestinal barrier dysfunction. Conclusion: Our findings suggest the possibility that, as the host ages, there is an increase in intestinal permeability, which leads to an increased intestinal microbial load and a reduction in the host lifespan. Our data therefore indicate a connection between commensal microbes and host lifespan. Full article
(This article belongs to the Special Issue The Insect Gut Barrier)
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