Surgical Treatment for Hepatocellular Carcinoma: Current Challenges and New Perspectives
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 128
Special Issue Editor
Special Issue Information
Dear Colleagues,
Hepatocellular carcinoma (HCC) is the most common primary liver cancer, the incidence of which is increasing (1). It is mainly associated with cirrhosis, most commonly in relation to HCV, MASLD, HBV, and alcoholic liver disease (2). In patients with a small lesion and no significant portal hypertension, liver resectioning has been performed in some centers. Deceased donor liver transplant is the main treatment in HCC patients within Milan/UCSF criteria. Patients who are beyond these criteria can be downstaged using locoregional therapy, such as Y90, or immunotherapy prior to liver transplant (3). There is growth in the utilization of living donor liver transplant in patients with HCC (4). Unfortunately, around 15-20% of patients who undergo liver transplant within standard criteria will develop tumor recurrence following liver transplant, which can be associated with high mortality (5). Patients with recurrence confined to the liver may be treated with liver resectioning or locoregional therapy (6). In this Special Issue, we review the most common literature in the advancement in surgical treatments and downstaging options in patients with HCC.
Topics of interest:
- Liver resection in patients with HCC and portal hypertension;
- Trend of DDLT for HCC in the US;
- Living donor liver transplant for HCC;
- Downstaging of HCC with locoregional therapy;
- Role of immunotherapy in downstaging of HCC;
- Tumor recurrence following liver transplant;
- Novel biomarkers for detection of recurrence post liver transplant;
- Surgical options for treatment of tumor recurrence following liver transplant.
Dr. Behnam Saberi
Guest Editor
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Keywords
- liver resection
- hepatocellular carcinoma (HCC)
- DDLT
- LDLT
- immunotherapy
- locoregional therapy
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