Surgical Treatment for Hepatocellular Carcinoma: Current Challenges and New Perspectives
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: 25 January 2025 | Viewed by 54
Special Issue Editor
Special Issue Information
Dear Colleagues,
Hepatocellular carcinoma (HCC) is the most common primary liver cancer, the incidence of which is increasing (1). It is mainly associated with cirrhosis, most commonly in relation to HCV, MASLD, HBV, and alcoholic liver disease (2). In patients with a small lesion and no significant portal hypertension, liver resectioning has been performed in some centers. Deceased donor liver transplant is the main treatment in HCC patients within Milan/UCSF criteria. Patients who are beyond these criteria can be downstaged using locoregional therapy, such as Y90, or immunotherapy prior to liver transplant (3). There is growth in the utilization of living donor liver transplant in patients with HCC (4). Unfortunately, around 15-20% of patients who undergo liver transplant within standard criteria will develop tumor recurrence following liver transplant, which can be associated with high mortality (5). Patients with recurrence confined to the liver may be treated with liver resectioning or locoregional therapy (6). In this Special Issue, we review the most common literature in the advancement in surgical treatments and downstaging options in patients with HCC.
Topics of interest:
- Liver resection in patients with HCC and portal hypertension;
- Trend of DDLT for HCC in the US;
- Living donor liver transplant for HCC;
- Downstaging of HCC with locoregional therapy;
- Role of immunotherapy in downstaging of HCC;
- Tumor recurrence following liver transplant;
- Novel biomarkers for detection of recurrence post liver transplant;
- Surgical options for treatment of tumor recurrence following liver transplant.
Dr. Behnam Saberi
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- liver resection
- hepatocellular carcinoma (HCC)
- DDLT
- LDLT
- immunotherapy
- locoregional therapy
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
