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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mitral Valve Surgery: Current Status and Future Challenges
edited by Antonio Lio and Marco Russo
submission deadline 5 Oct 2025 | 9 articles | Viewed by 10532 | Submission Open
Keywords: mitral valve; mitral valve repair; mitral valve replacement; minimally invasive surgery; robotic surgery
(This special issue belongs to the Section Cardiology)
Endovascular Surgery: State of the Art and Clinical Perspectives
edited by and Francesco Squizzato
submission deadline 9 Oct 2025 | 3 articles | Viewed by 2136 | Submission Open
Keywords: complex aortic endovascular repair; aortic arch endovascular surgery; endoleaks; PMEG; spinal cord ischemia; endograft-related adverse events
(This special issue belongs to the Section Vascular Medicine)
Current Measures for Diagnosis, Monitoring, and Outcome Assessment in Orthopedics, Traumatology, and Hand Surgery submission deadline 10 Oct 2025 | 9 articles | Viewed by 18075 | Submission Open
Keywords: clinical evaluation; hand surgery; orthopaedics; performance-based measures; physical examination; reliability; traumatology
(This special issue belongs to the Section Orthopedics)
Prevention and Sports Rehabilitation
edited by Sergio Hernandez-Sanchez and
submission deadline 10 Oct 2025 | 3 articles | Viewed by 12905 | Submission Open
Keywords: musculoskeletal pain; sport injury; therapeutic exercise; physiotherapy; load management; psychosocial; quality of life; prevention
(This special issue belongs to the Section Sports Medicine)
Breast Cancer: Clinical Diagnosis and Personalized Therapy
edited by
submission deadline 10 Oct 2025 | 6 articles | Viewed by 10371 | Submission Open
Keywords: breast cancer; imaging biomarkers; molecular biomarkers; precision medicine; loco-regional treatment; breast surgery; breast radiotherapy
(This special issue belongs to the Section Oncology)
Neurosurgery and Spine Surgery: From Up-to-Date Practitioners, 2nd Edition submission deadline 10 Oct 2025 | 6 articles | Viewed by 7011 | Submission Open
Keywords: neurosurgery; spine surgery; surgical techniques; research; advances; patient outcomes; interdisciplinary collaboration; healthcare; medical innovation; clinical practices
(This special issue belongs to the Section Clinical Neurology)
New Insights into Physical Therapy submission deadline 10 Oct 2025 | 3 articles | Viewed by 6743 | Submission Open
Keywords: physical rehabilitation; new technologies; virtual reality; augmented reality; telerehabilitation; clinical pilates; blood flow restriction; manual therapy; motor imagery; electrophysical modalities; therapeutic exercises; neurology; musculoskeletal; geriatric; respiratory; acute illness; cardiovascular
(This special issue belongs to the Section Sports Medicine)
Clinical Practice Guidelines for the Treatment and Management of Peripartum Depression, 2nd Edition
edited by
submission deadline 10 Oct 2025 | 2 articles | Viewed by 6005 | Submission Open
Keywords: peripartum depression; early detection; clinical health psychology; psychotherapy interventions; parental– infant well-being
(This special issue belongs to the Section Mental Health)
Pediatric Obesity: Causes, Prevention and Treatment
edited by
submission deadline 10 Oct 2025 | 3 articles | Viewed by 4243 | Submission Open
Keywords: 1000 first days of life; childhood obesity; lipids; healthy lifestyle; fetal programming
(This special issue belongs to the Section Endocrinology & Metabolism)
Skin Disease and Inflammation: Current Treatment and Future Options
edited by
submission deadline 10 Oct 2025 | 3 articles | Viewed by 3639 | Submission Open
Keywords: eczema; psoriasis; hidradenitis suppurativa; alopecia areata; acne; atopic dermatitis; urticaria; prurigo nodularis; lichen
(This special issue belongs to the Section Dermatology)
New Insights into Diabetes and Cardiovascular Diseases
edited by
submission deadline 10 Oct 2025 | 3 articles | Viewed by 2778 | Submission Open
Keywords: diabetes; cardiovascular diseases; heart failure; pharmacological approaches; SGLT2 inhibitors; GLP-1 receptor agonists
(This special issue belongs to the Section Cardiology)
Oral and Maxillofacial Surgery: Recent Clinical Advances and Future Directions
edited by Funda Göker, and
submission deadline 10 Oct 2025 | 2 articles | Viewed by 2660 | Submission Open
Keywords: oral and maxillofacial reconstructive surgery; MRONJ management; temporomandibular joint disorders; sental implants; zygomatic implants; guided surgery; alveolar bone regeneration; maxillofacial deformities; bone regeneration; head and neck cancer
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Outcomes Improvement and Perioperative Management of Surgical Patients: 2nd Edition submission deadline 12 Oct 2025 | 8 articles | Viewed by 13726 | Submission Open
Keywords: clinical outcomes; surgery; quality; quality of life; quality improvement; postoperative; morbidity; postoperative care
(This special issue belongs to the Section General Surgery)
Interventional Ultrasound Associated with Rehabilitation in the Treatment of Muscolo-Skeletal Disease
edited by Stefano Galletti and
submission deadline 12 Oct 2025 | Viewed by 134 | Submission Open
Keywords: ultrasound; infiltrative treatment; musculoskeletal imaging; rehabilitation; orthopedic; rheumatology; interventional ultrasound
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Diabetic Foot Complications: Current Challenges and Future Prospects—3rd Edition submission deadline 15 Oct 2025 | 10 articles | Viewed by 15280 | Submission Open
Keywords: diabetic foot ulcers; diabetic foot infections; charcot foot; peripheral vascular disease; prevention diabetic foot; lower limb amputation; diabetic foot mortality; biomechanics of diabetic foot
(This special issue belongs to the Section Endocrinology & Metabolism)
Clinical Management of Skin Cancer: From Pathology Advances to Techniques Applications
edited by Guy Orchard
submission deadline 15 Oct 2025 | 6 articles | Viewed by 15203 | Submission Open
Keywords: skin cancer; surgery; chemotherapy; radiotherapy; photothermal therapy; combination therapy; molecular target strategies
(This special issue belongs to the Section Dermatology)
New Concepts in the Diagnosis and Treatment of Orthopedic Diseases in Children submission deadline 15 Oct 2025 | 9 articles | Viewed by 14985 | Submission Open
Keywords: pediatric orthopedics; flatfoot; genu valgum; genu varum; hip dysplasia; clubfoot; early-onset scoliosis; Scheuermann disease; perthes; epiphysiolysis; scoliosis; pediatric trauma
(This special issue belongs to the Section Clinical Pediatrics)
Musculoskeletal Diagnosis and Treatment: Connecting Gaps to Enhance Patient Care
edited by
submission deadline 15 Oct 2025 | 5 articles | Viewed by 10279 | Submission Open
Keywords: musculoskeletal; back pain; neck pain; knee; shoulder; diagnosis; physiotherapy
(This special issue belongs to the Section Orthopedics)
Gallbladder, Bile Duct and Pancreas Disorders: Current Challenges, New Perspectives and Innovative Techniques
edited by , , Vasileios Papaziogas, Dimitrios Raptis and
submission deadline 15 Oct 2025 | 4 articles | Viewed by 9126 | Submission Open
Keywords: pancreas; biliary tract; pancreatobiliary diseases; pancreas neoplasm; tumor; ERCP; EUS; management; therapy; technique; surgery
(This special issue belongs to the Section General Surgery)
Clinical Research in Radiation Oncology: Current Status and Future Directions
edited by Paolo Borghetti
submission deadline 15 Oct 2025 | 2 articles | Viewed by 4034 | Submission Open
Keywords: radiation oncology; radiobiology; stereotactic body radiotherapy; multidisciplinary team; integrated treatment; predictive and prognostic biomarkers; cancer treatment
(This special issue belongs to the Section Oncology)
Chronic Kidney Disease Management: Integrating Pharmacotherapy, Biomarkers, and Lifestyle Interventions for Improved Outcomes
edited by
submission deadline 15 Oct 2025 | 2 articles | Viewed by 1510 | Submission Open
Keywords: nephrology; chronic kidney disease; cardiovascular risk; risk stratification; biomarkers; evidence-based treatment
(This special issue belongs to the Section Nephrology & Urology)
Diagnosis and Treatment of Sjogren’s Syndrome: 2nd Edition
edited by
submission deadline 15 Oct 2025 | 1 articles | Viewed by 1375 | Submission Open
Keywords: biological agents; JAK inhibitors; magnetic resonance imaging; noncoding RNA; Sjö gren's syndrome; ultrasound
(This special issue belongs to the Section Immunology & Rheumatology)
New Approaches in Bariatric Surgery
edited by
submission deadline 15 Oct 2025 | 1 articles | Viewed by 859 | Submission Open
Keywords: bariatric surgery; metabolic surgery; endoscopic sleeve gastroplasty; PROM in bariatric surgery; BariClip
(This special issue belongs to the Section General Surgery)
Retinal Dystrophies—Structure and Function Relationship submission deadline 15 Oct 2025 | 1 articles | Viewed by 611 | Submission Open
Keywords: retinal dystrophies; structural changes; functional impairment; in retinal degenerative diseases; retinitis pigmentosa
(This special issue belongs to the Section Ophthalmology)
Clinical Diagnostics and Therapeutic Advances in Pregnancy Complications submission deadline 15 Oct 2025 | 1 articles | Viewed by 538 | Submission Open
Keywords: prenatal diagnosis; pre-eclampsia; gestational diabetes; pregnancy complications; preterm labor; congenital mal-formations; prenatal genetic testing
(This special issue belongs to the Section Obstetrics & Gynecology)
Recent Advancements in Periodontal and Peri-Implant Disease Management
edited by and Leticia Helena Theodoro
submission deadline 15 Oct 2025 | Viewed by 172 | Submission Open
Keywords: periodontal disease; peri-implantitis; periodontal medicine; complications and management
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
New Advances in the Diagnosis and Treatment of Breast Cancer
edited by Massimo Ferrucci, Giacomo Montagna, and Alberto Marchet
submission deadline 17 Oct 2025 | 1 articles | Viewed by 540 | Submission Open
Keywords: breast cancer; innovative imaging technologies; personalized treatment approaches; surgical de-escalation; onco-plastic and reconstructive surgery; targeted therapies; immunotherapy; artificial intelligence; radiotherapy ad-vancements; lifestyle factors
(This special issue belongs to the Section Oncology)
Psychogerontology: Psychological Insights into Aging
edited by Sónia Martins and
submission deadline 17 Oct 2025 | Viewed by 314 | Submission Open
Keywords: psychogerontology; aging process; adjustment; mental health; psychopatology; personality; emotions; well-being; spir-ituality; quality of life; caregiving; psychogerontology assessment and interventions
(This special issue belongs to the Section Mental Health)
Structural Heart Diseases: Current Challenges and Opportunities
edited by Anton Camaj
submission deadline 19 Oct 2025 | Viewed by 158 | Submission Open
Keywords: structural heart disease; transcatheter; electrosurgery; valvular heart disease; radiation safety; hypertrophic obstructive cardiomyopathy; adult congenital cardiac disease
(This special issue belongs to the Section Cardiology)
Mood Disorders: Diagnosis, Management and Future Opportunities
edited by
submission deadline 20 Oct 2025 | 15 articles | Viewed by 37475 | Submission Open
Keywords: mood disorders; depression; anxiety; stress; trauma; suicide; mental health diagnosis and treatment
(This special issue belongs to the Section Mental Health)
Treatment Personalization in Clinical Psychology and Psychotherapy
edited by
submission deadline 20 Oct 2025 | 11 articles | Viewed by 24100 | Submission Open
Keywords: treatment personalization; clinical psychology; psychotherapy; personalized treatment; psychosomatic interventions; coping and personalization
(This special issue belongs to the Section Mental Health)
Inflammatory Bowel Disease: Clinical Advances and Therapeutic Prospects submission deadline 20 Oct 2025 | 9 articles | Viewed by 22793 | Submission Open
Keywords: inflammatory bowel disease; Crohn's disease; ulcerative colitis; risk factors; therapeutic strategies
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Applications of Artificial Intelligence and Digital Therapeutics in Clinical Medicine
edited by
submission deadline 20 Oct 2025 | 12 articles | Viewed by 17693 | Submission Open
Keywords: artificial intelligence; biometric sensors; deep learning; digital therapies; Internet of Things; machine learning; virtual reality; augmented reality
(This special issue belongs to the Section Clinical Guidelines)
Metabolic Syndrome and Its Burden on Global Health
edited by Umberto Goglia, Luca Monge, , and
submission deadline 20 Oct 2025 | 8 articles | Viewed by 16370 | Submission Open
Keywords: insulin resistance; chronic low-grade inflammation; gut microbiota; energy balance; obesity; hyperlipidemia; metabolic dysfunction-associated steatotic liver (MASLD); type 2 diabetes mellitus; heart failure; diabetic cardiomyopathy; cardio-nephro-metabolic syndrome; metabolic syndrome sex differences; metabolic syndrome and health inequity; metabolic syndrome health-economic burden
(This special issue belongs to the Section Endocrinology & Metabolism)
Novelties in the Treatment of Glomerulonephritis submission deadline 20 Oct 2025 | 5 articles | Viewed by 13922 | Submission Open
Keywords: glomerulonephritis; primary and secondary; IGA nephritis; membranous nephropathy; minimal change nephropathy; glomerulosclerosis; C3 glomerulonephritis; vasculitis systemic steroids; budesonide; alkilants; cyclosporine; complement; rituximab; SGLT2; sparsentan
(This special issue belongs to the Section Nephrology & Urology)
Advances in Allergic Diseases and Asthma: Clinical Insights and Emerging Therapies
edited by
submission deadline 20 Oct 2025 | 5 articles | Viewed by 13173 | Submission Open
Keywords: allergic diseases; asthma management; airway obstruction; allergy diagnosis; angioedema; urticaria
(This special issue belongs to the Section Immunology & Rheumatology)
General Anesthesia: Recent Developments and Emerging Trends
edited by Basavana Goudra
submission deadline 20 Oct 2025 | 3 articles | Viewed by 11264 | Submission Open
Keywords: general anesthesia; recent advances; drug development; memory and awareness; brain monitoring; sugammadex; tegileridine
(This special issue belongs to the Section Anesthesiology)
Clinical Application of Endoscopic Submucosal Dissection in Malignant Gastrointestinal Tumors and Precursors submission deadline 20 Oct 2025 | 6 articles | Viewed by 10564 | Submission Open
Keywords: endoscopy; endoscopic submucosal dissection; endoscopic surgery; laparoscopic surgery; minimally invasive surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Thrombosis and Haemostasis
edited by
submission deadline 20 Oct 2025 | 3 articles | Viewed by 9614 | Submission Open
Keywords: coagulation; immunothrombosis; inflammation; immune response; venous thrombosis; arterial thrombosis; endothelial dysfunction; neutrophil extracellular traps
(This special issue belongs to the Section Hematology)
Clinical Updates on Shoulder Arthroplasty submission deadline 20 Oct 2025 | 7 articles | Viewed by 8862 | Submission Open
Keywords: reverse shoulder arthroplasty (RSA); rotator cuff arthropathy; revisions; hemiarthroplasty; proximal humeral fractures; osteoarthritis; 3D planning; complications; total shoulder arthroplasty (TSA)
(This special issue belongs to the Section Orthopedics)
Clinical Insights into Pulmonary Hypertension
edited by Simon Schneider
submission deadline 20 Oct 2025 | 5 articles | Viewed by 7987 | Submission Open
Keywords: pulmonary hypertension; pulmonary vascular disease (PVD); pulmonary arterial hypertension (PAH); chronic thromboembolic pulmonary hypertension (CTEPH); interstitial lung disease; chronic obstructive pulmonary disease (COPD); chronic pulmonary fibrosis; emphysema; respiratory disease; physiology; diagnosis; treatment; rehabilitation; altitude research
(This special issue belongs to the Section Respiratory Medicine)
Sleep Disorders: Current Research and Future Directions
edited by Martina Vendrame
submission deadline 20 Oct 2025 | 4 articles | Viewed by 7513 | Submission Open
Keywords: obstructive sleep apnea; parasomnia; idiopathic hypersomnia; periodic limb movement disorder; periodic limb move-ment of sleep
(This special issue belongs to the Section Clinical Neurology)
Personalized Therapy and Clinical Outcomes for Congenital Heart Disease
edited by Giancarlo Scognamiglio and Flavia Fusco
submission deadline 20 Oct 2025 | 5 articles | Viewed by 7430 | Submission Open
Keywords: personalized therapy; clinical outcome; heart failure therapy; anti-arrhythmic therapy; sudden death prevention; adult congenital heart failure; prognosis
(This special issue belongs to the Section Cardiology)
Recent Clinical Advances in Cardiac Rehabilitation
edited by
submission deadline 20 Oct 2025 | 6 articles | Viewed by 7199 | Submission Open
Keywords: cardiac rehabilitation; kinesiotherapy; psychological support; lifestyle modifications; myocardial infarction; heart failure
(This special issue belongs to the Section Cardiology)
Clinical Advances in Child Neurology
edited by Claire Marie Rangon and
submission deadline 20 Oct 2025 | 4 articles | Viewed by 6249 | Submission Open
Keywords: non-invasive; invasive; neuromodulation; children; neurodevelopmental disorders; autism spectrum disease; refractory epilepsy; vagus nerve stimulation
(This special issue belongs to the Section Clinical Pediatrics)
Evolution of Breast Reconstruction: Current Techniques, Advances and Future Directions
edited by and Andrea Moreira
submission deadline 20 Oct 2025 | 4 articles | Viewed by 6048 | Submission Open
Keywords: breast reconstruction; microsurgery; robot-assisted surgery; breast neurotization; lymphatic surgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Clinical Advances in Diabetes, Obesity, and Hypertension submission deadline 20 Oct 2025 | 5 articles | Viewed by 5170 | Submission Open
Keywords: obesity; hypertension; diabetes; lifestyle; physical activity; risk factors
(This special issue belongs to the Section Endocrinology & Metabolism)
Current State of the Art in Breast Reconstruction
edited by Ara A. Salibian and David Daar
submission deadline 20 Oct 2025 | 4 articles | Viewed by 5013 | Submission Open
Keywords: breast reconstruction; microsurgery; breast cancer; breast implant; DIEP Flap
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Current Progress in Inflammatory Bowel Disease (IBD)
edited by and Simona Grad
submission deadline 20 Oct 2025 | 5 articles | Viewed by 4909 | Submission Open
Keywords: assessment and diagnosis of IBD; diet and nutrition in IBD; Microbiota and IBD; RCTs in IBD; new therapies in IBD; meta-analyses and systematic reviews in IBD; psychological impact and quality of life in IBD; imaging techniques in IBD; pathogenesis of IBD (including the impact of disrupted barrier function)
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Transcatheter Aortic Valve Implantation: Recent Advances and Future Directions
edited by and Pablo Codner
submission deadline 20 Oct 2025 | 5 articles | Viewed by 4588 | Submission Open
Keywords: transcatheter aortic valve implantation; transcatheter aortic valve replacement; aortic valve stenosis; aortic valve regurgitation; aoric valve disease; cardiac imaging; artifical intelligence; machine learning
(This special issue belongs to the Section Cardiovascular Medicine)
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