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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Thyroid Disease: Updates from Diagnosis to Treatment
edited by and Petra Petranović Ovčariček
submission deadline 28 Jun 2025 | 8 articles | Viewed by 11163
Keywords: autoimmune thyroid diseases; thyroiditis; thyroid cancers; PET/CT; hyperthyroidism
(This special issue belongs to the Section Endocrinology & Metabolism)
Recent Advances in Pulmonary Embolism and Thrombosis
edited by and Mauro Silingardi
submission deadline 30 Jun 2025 | 10 articles | Viewed by 43589 | Submission Open
Keywords: pulmonary embolism; embolism and thrombosis; thrombus aspiration for pulmonary embolism; deep vein throm-bosis; venous thromboembolism
(This special issue belongs to the Section Respiratory Medicine)
Current and Future Trends in Otorhinolaryngology–Head and Neck Surgery submission deadline 30 Jun 2025 | 15 articles | Viewed by 24241 | Submission Open
Keywords: otorhinolaryngology; head and neck; innovation; diagnosis; treatment; surgery
(This special issue belongs to the Section Otolaryngology)
New Advances in Optic Nerve Diseases
edited by
submission deadline 30 Jun 2025 | 9 articles | Viewed by 20320 | Submission Open
Keywords: optic nerve; optic nerve diseases; optic neuritis; glaucoma; optic neuropathies; optical coherence tomography; OCT; ocular ultrasonography
(This special issue belongs to the Section Ophthalmology)
An Update on Retinal Diseases: From Diagnosis to Treatment
edited by , Masahiko Sugimoto and Kenji Yamashiro
submission deadline 30 Jun 2025 | 12 articles | Viewed by 15436 | Submission Open
Keywords: retinal diseases; diagnosis; treatment; etiology; original article; review paper
(This special issue belongs to the Section Ophthalmology)
Updates on Neurostimulation: From Mechanistic Principles to Clinical Applications submission deadline 30 Jun 2025 | 6 articles | Viewed by 15124 | Submission Open
Keywords: brain stimulation; non-invasive brain stimulation; deep brain stimulation; neuroimaging; computational modelling; therapy
(This special issue belongs to the Section Clinical Neurology)
Diagnosis, Treatment and Prognosis of Coronary Heart Disease
edited by
submission deadline 30 Jun 2025 | 9 articles | Viewed by 14956 | Submission Open
Keywords: coronary heart disease; acute coronary syndrome; chronic coronary syndrome; ischemia with no obstructive coronary arteries (INOCA); guideline-directed optimal medical therapy; precision medicine; artificial intelligence; interventional cardiology; percutaneous coronary intervention (PCI)
(This special issue belongs to the Section Cardiology)
Chronicity, Multimorbidity, and Medication Appropriateness submission deadline 30 Jun 2025 | 9 articles | Viewed by 14393 | Submission Open
Keywords: multimorbidity; chronic diseases; drug utilization; polypharmacy; medication appropriateness; medication adherence; drug interactions; care models; chronic inflammation; interventions
(This special issue belongs to the Section Pharmacology)
Current Trends and Innovations in Coronary Artery Disease and Myocardial Ischemia
edited by
submission deadline 30 Jun 2025 | 6 articles | Viewed by 13170 | Submission Open
Keywords: coronary artery disease; fractional flow reserve; invasive coronary angiography; cardiac CT; cardiac MRI
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Advances in Vascular and Endovascular Surgery
edited by Toshifumi Kudo
submission deadline 30 Jun 2025 | 11 articles | Viewed by 12401 | Submission Open
Keywords: aortic aneurysm; peripheral arterial disease; chronic limb-threatening ischemia; endovascular aneurysm repair; endovascular treatment; non-invasive blood flow measurements; varicose veins; deep venous thrombosis
(This special issue belongs to the Section Vascular Medicine)
Early Clinical Diagnosis of and Intervention in Pediatric Cerebral Palsy submission deadline 30 Jun 2025 | 8 articles | Viewed by 12335 | Submission Open
Keywords: cerebral palsy; early diagnosis; family factors; associated impairments; outcome measures; intervention; mental health
(This special issue belongs to the Section Clinical Pediatrics)
Vitreoretinal Disease: Clinical Insights and Treatment Strategies
edited by
submission deadline 30 Jun 2025 | 8 articles | Viewed by 11246 | Submission Open
Keywords: vitreoretinal disease; age-related macular degeneration; diabetic retinopathy; retinal detachments; retinitis pig-mentosa; flashes and floaters; macular holes
(This special issue belongs to the Section Ophthalmology)
Treatment of Atopic Dermatitis
edited by and Ricardo Ruíz-Villaverde
submission deadline 30 Jun 2025 | 5 articles | Viewed by 10527 | Submission Open
Keywords: atopic dermatitis; eczema; topical treatment; systemic treatment; biological therapy; JAK inhibitor; antipruritic treatment
(This special issue belongs to the Section Dermatology)
Advances in Orthopedic Trauma Surgery in Geriatrics
edited by Ulrich Christoph Liener
submission deadline 30 Jun 2025 | 7 articles | Viewed by 10207 | Submission Open
Keywords: geriatric fractures; orthogeriatric care; osteoporosis; frailty; fragillity fractures; multidisciplinary care
(This special issue belongs to the Section Orthopedics)
Oral and Maxillofacial Surgery: Recent Advances and Future Directions submission deadline 30 Jun 2025 | 7 articles | Viewed by 9233 | Submission Open
Keywords: orthodontics; dentofacial orthopedics; bone regeneration; oral health; dentistry; digital technologies; virtual care
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advances in Traumatic Brain Injury
edited by
submission deadline 30 Jun 2025 | 4 articles | Viewed by 7977 | Submission Open
Keywords: traumatic brain injury; guideline/recommendations; concordant care; resource limited clinical setting; multimodal monitoring; neuroprognostication; safe/effective/patient-centered/timely/efficient/equitable care; quality improvement
(This special issue belongs to the Section Clinical Neurology)
Microsurgery: Current and Future Perspectives
edited by , Michele Riccio, Luca Vaienti, and
submission deadline 30 Jun 2025 | 5 articles | Viewed by 7823 | Submission Open
Keywords: plastic surgery; reconstructive surgery; microsurgery; free flap; free tissue transfer
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
New Insights into Corneal Regeneration and Transplantation submission deadline 30 Jun 2025 | 4 articles | Viewed by 6947 | Submission Open
Keywords: cornea; corneal surface disease; corneal transplantation; eye banking; corneal stem cells; corneal immunology
(This special issue belongs to the Section Ophthalmology)
Polycystic Ovary Syndrome (PCOS): State of the Art: 2nd Edition
edited by
submission deadline 30 Jun 2025 | 4 articles | Viewed by 6614 | Submission Open
Keywords: polycystic ovary syndrome; hirsutism; obesity; insulin resistance; amenorrhea; adult acne; female pattern hair loss; polycystic ovaries; anti-Mullerian hormone
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Application of Physical Therapy in Neurorehabilitation: 2nd Edition submission deadline 30 Jun 2025 | 3 articles | Viewed by 6359 | Submission Open
Keywords: physical therapy; technology-aided rehabilitation; exercise; neurorehabilitation; neuroplasticity; engagement; self-management
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Advances in Aortic Disease and Revascularization
edited by Andrej Udelnow
submission deadline 30 Jun 2025 | 6 articles | Viewed by 6330 | Submission Open
Keywords: aortic disease; aortic aneurysm; endovascular aortic repair; atherosclerosis; aortic dissections; overall survival; quality of life; intravascular ultrasound
(This special issue belongs to the Section Vascular Medicine)
New Clinical Advances in Sudden Cardiac Arrest and Ventricular Arrhythmias
edited by
submission deadline 30 Jun 2025 | 4 articles | Viewed by 5833 | Submission Open
Keywords: cardiac arrest; defibrillation; ventricular tachycardia; ventricular fibrillation; catheter ablation; non-invasive ablation; neuromodulation; stellate ganglion block
(This special issue belongs to the Section Cardiology)
Cardiac Electrophysiology: New Insights and Future Directions
edited by
submission deadline 30 Jun 2025 | 4 articles | Viewed by 5538 | Submission Open
Keywords: cardiac arrhythmias; atrial fibrillation; ventricular arrhythmias; remote monitoring; implantable cardioverter– defibrillators; cardiac resynchronization therapy; catheter ablation; channelopathies
(This special issue belongs to the Section Cardiology)
Advances in Cardiac Resynchronization Treatment
edited by , Konstantinos A. Gatzoulis and
submission deadline 30 Jun 2025 | 4 articles | Viewed by 5457 | Submission Open
Keywords: conduction system; risk stratification; resynchronization; cardiac pacing; sudden cardiac death
(This special issue belongs to the Section Cardiology)
Trauma and Acute Care Surgery Research: Innovations, Challenges, and Future Directions
edited by Frederick Rogers
submission deadline 30 Jun 2025 | 3 articles | Viewed by 5242 | Submission Open
Keywords: trauma care; best practices; clinical care; trauma system development; optimal trauma care
(This special issue belongs to the Section Intensive Care)
Inflammatory Bowel Diseases in 2024 and Beyond: From Diagnosis to Treatment
edited by and Sara Onali
submission deadline 30 Jun 2025 | 4 articles | Viewed by 4928 | Submission Open
Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; target therapy; nutrition; early diagnosis; inflammatory biomarkers
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Thoracic Surgery: Current Challenges and Future Perspectives
edited by and José Luis Campo-Cañaveral de la Cruz
submission deadline 30 Jun 2025 | 5 articles | Viewed by 4843 | Submission Open
Keywords: minimally invasive surgery; robotic-assisted thoracic surgery; lung cancer management; esophageal surgery; pleural diseases and interventions; thoracic trauma surgery; tracheal and bronchial surgery; thoracic endoscopy; lung transplantation; lung segmentectomy; 3D printing; pneumothorax; surgical planification; education; simulation; artificial intelligence
(This special issue belongs to the Section Respiratory Medicine)
Targeted Treatment of Kidney Stones
edited by Carmen Gonzalez-Enguita and
submission deadline 30 Jun 2025 | 2 articles | Viewed by 4567 | Submission Open
Keywords: shockwave lithotripsy; ureteroscopy; percutaneous nephrolithotomy; laser lithotripsy; minimally invasive techniques; stone recurrence prevention
(This special issue belongs to the Section Nephrology & Urology)
Clinical Perspectives for Headache and Neuropathic Pain
edited by Soo-Jin Cho
submission deadline 30 Jun 2025 | 5 articles | Viewed by 4157 | Submission Open
Keywords: headache; migraine; reversible vasoconstrictino syndrome; calcitonine-gene-related peptide; neuropathic pain; chemothera-py-induced peripheral neuropathy; central sensitization
(This special issue belongs to the Section Clinical Neurology)
Clinical Advances in Cardiac Anesthesia and Critical Care
edited by and Tiziano Cassina
submission deadline 30 Jun 2025 | 3 articles | Viewed by 4138 | Submission Open
Keywords: cardiac anesthesia; critical care; perioperative organ protection; multimodal analgesia; regional anesthesia; spinal analgesia; perioperative imaging; 3D transesophageal echocardiography
(This special issue belongs to the Section Anesthesiology)
The Influence of Laparoscopic and Robotic Surgery on Abdominal Diseases and Current Clinical Treatments
edited by , Maurizio De Maria and Niccolò Petrucciani
submission deadline 30 Jun 2025 | 1 articles | Viewed by 4122 | Submission Open
Keywords: laparoscopic surgery; robotic surgery; minimally invasive surgery; upper GI surgery; colorectal surgery; HBP surgery; transplantation; urology; obstetrics and gynecology
(This special issue belongs to the Section General Surgery)
Male Infertility Update: Current Knowledge on Etiology, Comorbidities, Diagnosis and Treatment: Clinical Topics submission deadline 30 Jun 2025 | 1 articles | Viewed by 3914 | Submission Open
Keywords: male infertility; diagnosis; treatment; etiology; pre-testicular/testicular/post-testicular causes; genetic causes; seminal parameters; hormonal parameters; ultrasound; general health; azoospermia
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Targeted Diagnosis and Treatment of Dementia: Current Concepts and New Horizons
edited by Eli Wertman
submission deadline 30 Jun 2025 | 3 articles | Viewed by 3775 | Submission Open
Keywords: dementia; pre-dementia; diagnosis; targeted therapies; cognitive assessment; behavioral syndromes neuroimaging; multimorbidity; pharmacological interventions; non-pharmacological approaches; case management; supportive care; remediability
(This special issue belongs to the Section Mental Health)
Causes and Advanced Treatments of Macular Edema submission deadline 30 Jun 2025 | 3 articles | Viewed by 3608 | Submission Open
Keywords: macular edema; laser photocoagulation; subthreshold laser; anti-VEGF; optical coherence tomography; fluorescein angiography; angio-OCT
(This special issue belongs to the Section Ophthalmology)
New Insights in the Endovascular Treatment of Aortic Type A Dissection
edited by
submission deadline 30 Jun 2025 | 2 articles | Viewed by 3332 | Submission Open
Keywords: aortic dissection; endovascular treatment; type A dissection; thoracic aorta; stent graft; minimally invasive surgery; hybrid procedures; complications; long-term outcomes; patient selection
(This special issue belongs to the Section Cardiology)
Clinical Trends and Prospects in Urology Surgery
edited by , and Patrick Juliebø-Jones
submission deadline 30 Jun 2025 | 3 articles | Viewed by 3063 | Submission Open
Keywords: robotic surgery; laparoscopic surgery; endourology; minimally invasive surgery; artificial intelligence
(This special issue belongs to the Section Nephrology & Urology)
Clinical Advances in Urinary Surgery
edited by Nir Kleinmann and
submission deadline 30 Jun 2025 | 2 articles | Viewed by 2833 | Submission Open
Keywords: endourology; laparoscopic urology; urologic oncology; urolithiasis; robot-assisted surgery; endoscopic surgery
(This special issue belongs to the Section Nephrology & Urology)
Emerging Therapies for Multiple Myeloma
edited by Brea C. Lipe
submission deadline 30 Jun 2025 | 2 articles | Viewed by 2801 | Submission Open
Keywords: multiple myeloma; immunotherapy; targeted therapy; CAR-T cell therapy; new drugs; transplant
(This special issue belongs to the Section Hematology)
Current Practice and Future Perspectives of Neurological Conditions Caused by Neurodegeneration, 2nd Edition
edited by
submission deadline 30 Jun 2025 | 2 articles | Viewed by 2796 | Submission Open
Keywords: neurodegenerative diseases; amyotrophic lateral sclerosis; multiple sclerosis; Parkinson's disease; Alzheimer's disease; Huntington's disease; multiple-system atrophy; prion diseases; stroke
(This special issue belongs to the Section Clinical Neurology)
New Insights into Orthopedic Trauma Surgery—Pelvic and Acetabular Fracture Management
edited by Vera Jaecker and
submission deadline 30 Jun 2025 | 2 articles | Viewed by 2641 | Submission Open
Keywords: acetabular fractures; pelvic fractures; trauma surgery; intrapelvic approaches; fragility fractures of the pelvis; minimally invasive approaches; new implants; innovations
(This special issue belongs to the Section Orthopedics)
Pelvic Organ Prolapse: Current Challenges and Future Perspectives
edited by Marco Soligo
submission deadline 30 Jun 2025 | 2 articles | Viewed by 2591 | Submission Open
Keywords: pelvic organ prolapse; urinary incontinence; lower urinary disorders; quality of life; patient-reported outcomes
(This special issue belongs to the Section Obstetrics & Gynecology)
Gastroesophageal Cancer: Outcomes and Therapeutic Management
edited by Michael K. Gibson
submission deadline 30 Jun 2025 | 3 articles | Viewed by 2538 | Submission Open
Keywords: gastroesophageal cancer; targeted therapy; circulating tumor DNA; precision medicine; immune checkpoint inhibitors; esophageal cancer; gastric cancer; biomarkers; molecular characterization
(This special issue belongs to the Section Oncology)
Targeted Diagnosis and Advances in the Clinical Application of Infectious Diseases submission deadline 30 Jun 2025 | 2 articles | Viewed by 2497 | Submission Open
Keywords: care-associated infections; emerging infections; prevention and control measures and guidelines; prevention and control training
(This special issue belongs to the Section Infectious Diseases)
Current Challenges in the Management of Vitreoretinal Conditions: 2nd Edition
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 2450 | Submission Open
Keywords: retina; anti-VEGF; implants; macular degeneration; diabetic retinopathy; vein occlusions; retinal detachments; vit-reoretinal surgery; COVID-19 impact
(This special issue belongs to the Section Ophthalmology)
Advances in Echocardiography and Its Clinical Applications
edited by
submission deadline 30 Jun 2025 | 3 articles | Viewed by 2346 | Submission Open
Keywords: Doppler imaging; speckle tracking echocardiography; myocardial work; intracardiac flow dynamics; three-dimensional echocardiography; stress echocardiography; transoesophageal echocardiography; contrast echocardiography; artificial intelligence
(This special issue belongs to the Section Cardiovascular Medicine)
Recent Advances in Glaucoma Management
edited by Bogomil Voykov
submission deadline 30 Jun 2025 | 3 articles | Viewed by 2313 | Submission Open
Keywords: glaucoma; MIGS; microinvasive glaucoma surgery; quality of life; sustained-release drugs; wound healing modula-tion; intraocular pressure; intraocular pressure-lowering medication; microstent-supported bleb surgery; MIBS; neuroprotection
(This special issue belongs to the Section Ophthalmology)
Advances in Rehabilitation Care for Geriatric Diseases
edited by
submission deadline 30 Jun 2025 | 3 articles | Viewed by 2167 | Submission Open
Keywords: geriatric rehabilitation; holistic physiotherapy; physical activity; health outcomes; elderly people; geriatric care; chronic disease; health promotion
(This special issue belongs to the Section Clinical Rehabilitation)
Differential Effects of Bariatric Surgery (BS) and Endoscopic Bariatric Therapy (EBT) on Long and Short-Term Metabolic Outcomes
edited by Mohamad Mokadem
submission deadline 30 Jun 2025 | 3 articles | Viewed by 1820 | Submission Open
Keywords: obesity; bariatric surgery; endoscopic bariatric therapy; metabolic surgery; weight loss; metabolism; weight management
(This special issue belongs to the Section Endocrinology & Metabolism)
Current Trends and Future Directions in Plastic and Reconstructive Surgery
edited by Emilio Trignano
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1804 | Submission Open
Keywords: plastic and reconstructive surgery; breast reconstruction; liposuction; tarsal tunnel syndrome; vasoconstriction; pneumomediastinum; abdominal wall surgery; vulvectomy
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
New Insights into Diabetic Foot
edited by Prashanth Vas and
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1799 | Submission Open
Keywords: diabetic foot syndrome; diabetic foot infection; diabetic foot osteomyelitis; peripheral arterial disease; ischaemic ulcer; diabetic neuropathy
(This special issue belongs to the Section Endocrinology & Metabolism)
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