Updates and Advances in Aplastic Anemia and Other Bone Marrow Failures
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".
Deadline for manuscript submissions: 15 April 2026 | Viewed by 31
Special Issue Editors
Interests: bone marrow failures; SAA; cytopenias; ITP; myeloproliferative neoplasms (MPN); late effects after hematopoietic cell transplantation (HCT); myeloproliferative/myelodysplastic syndromes (MPN/MDS); myelodysplastic syndromes (MDS)
Interests: bone marrow failures; predisposition syndromes; paroxysmal nocturnal hemoglobinuria
2. Laboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences, University of Lausanne (UNIL), Lausanne, Switzerland
Interests: hematopoiesis; hematopoietic microenvironment; bone marrow failure; aplasia, bone marrow adipocytes; artificial niches
Special Issue Information
Dear Colleagues,
This Special Issue will gather scientific articles reviewing recent advances in aplastic anemia and other bone marrow failures syndromes, focusing on new perspectives for improving patient diagnosis, treatment, and care. Even with the integration of novel advanced diagnostic tools, therapeutic approaches, multidisciplinary management strategies, and emerging insights into immunology and genetics, aplastic anemia remains a complex and rapidly evolving hematological disorder.
The included articles provide a comprehensive overview of the latest news in the field, such as improvements in bone marrow failure diagnosis, the optimization of immunosuppressive and adjuvant therapies to stimulate hematopoiesis, advancements in hematopoietic stem cell transplantation techniques, and the development of novel targeted treatments including cellular therapies. Significant emphasis is placed on the differential diagnosis of congenital bone marrow failures in children and adults up to 50 years old, highlighting newly identified genetic conditions and their impact on transplantation decisions. Furthermore, special attention is given to new transplantation approaches for patients with bone marrow failure. Long-term outcomes in aplastic anemia patients remain a vital area of research.
Reflecting on achievements, this Special Issue will consider future challenges and opportunities, focusing on promising areas such as gene editing to correct inherited defects, advances in transplantation procedures, and the integration of artificial intelligence in personalized diagnosis and treatment planning. The goal is to provide a comprehensive and current understanding of both acquired and inherited bone marrow failures, supporting ongoing efforts to enhance patient survival and quality of life.
Prof. Dr. Alicia Rovo
Dr. Beatrice Drexler
Prof. Dr. Olaia Naveiras
Guest Editors
Manuscript Submission Information
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Keywords
- aplastic anemia
- severe aplastic anemia (SAA)
- bone marrow failures
- paroxysmal nocturnal hemoglobinuria (PNH)
- inherited bone marrow failures
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