Advancements in Cornea Transplantation

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Guest Editor
Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome, Italy
Interests: cornea; corneal infections; corneal neovascularization; corneal transplant; keratoconus; dry eye
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Guest Editor
Eye Clinic, Department of Neurological and Vision Sciences, University of Brescia, 25125 Brescia, Italy
Interests: corneal transplantation; cataract; refractive surgery; keratitis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, advancements in corneal transplantation have significantly improved the outcomes and expanded the scope of this critical ophthalmic procedure. Notable developments are the evolution of lamellar procedures, such as deep anterior lamellar keratoplasty (DALK), and endothelial keratoplasty techniques, such as Descemet membrane endothelial keratoplasty (DMEK) and Descemet's stripping automated endothelial keratoplasty (DSAEK). These procedures target the replacement of specific layers of the cornea, enhancing visual recovery and reducing graft rejection.

Additionally, advancements in tissue engineering and regenerative medicine have paved the way for innovative approaches, such as bioengineered corneal tissue and the use of RHO-kinase inhibitors. These emerging technologies aim to address the limitations of traditional donor-dependent transplantation by providing alternative sources of corneal tissue. Furthermore, ongoing research focuses on refining immunosuppressive strategies to minimize graft rejection and improve long-term graft survival.

In conclusion, recent advancements in corneal transplantation encompass a spectrum of innovations, ranging from surgical techniques and technology integration to tissue engineering and immunomodulation. These advancements collectively contribute to the continued enhancement of patient outcomes and the evolution of corneal transplantation as a sophisticated and effective therapeutic modality in ophthalmology.

The aim of this Special Issue is to present original studies as well as reviews on corneal transplantation. Authors should submit articles on themes including, but not limited to, in vivo models; the evaluation of technology for the clinical assessment of corneal transplants and outcomes; improvements in the diagnosis of diseases that may lead to corneal transplantation; and transplant techniques, management, and outcomes.

You may choose our Joint Special Issue in JCM.

Dr. Giulia Coco
Dr. Davide Romano
Guest Editors

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Keywords

  • corneal transplant
  • keratoplasty
  • DMEK
  • DSAEK
  • PK
  • cornea

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Published Papers (1 paper)

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Review

13 pages, 908 KiB  
Review
Corneal Graft Dehiscence in Patients on Oral Angiotensin-Inhibiting Medications: Plausible Relationship and Review of the Literature
by Jie Zhang and Jay J Meyer
J. Clin. Transl. Ophthalmol. 2025, 3(1), 4; https://doi.org/10.3390/jcto3010004 - 27 Feb 2025
Viewed by 311
Abstract
Wound dehiscence is a rare complication after penetrating keratoplasty (PK) that may occur with or without prior trauma. Multiple factors may influence corneal wound healing, including patient factors, corneal wound characteristics, and other external factors. There is also the possibility that systemic medications [...] Read more.
Wound dehiscence is a rare complication after penetrating keratoplasty (PK) that may occur with or without prior trauma. Multiple factors may influence corneal wound healing, including patient factors, corneal wound characteristics, and other external factors. There is also the possibility that systemic medications could impact corneal wound healing. Possible factors that may predispose a cornea to experience wound dehiscence are discussed. We propose a hypothesis that oral angiotensin-inhibiting medications could play a role in reduced corneal wound healing. A literature review was conducted to investigate the effect of angiotensin inhibitors on corneal wound healing. Five patients on systemic oral angiotensin-inhibiting medications at the time of PK developed dehiscence of the graft–host wound junction following removal of sutures. The dehiscence required resuturing in all cases and resulted in an expulsive choroidal hemorrhage and complete loss of vision in one eye. Age, diabetes, lack of corneal neovascularization, early suture removal, underlying epithelial basement membrane dystrophy, corneal oedema, slower tapering of topical corticosteroid dosage, and glaucoma medication with preservatives were possible predisposing factors for some of these instances of wound dehiscence. However, oral angiotensin-inhibiting medications were taken by all patients in this series, and the literature suggests that ACE inhibitors and ARBs can reduce corneal fibrosis, resulting in inadequate healing. Oral angiotensin-inhibiting medications could have played an anti-fibrotic role in these corneae and predisposed them to wound dehiscence with minimal trauma. Despite limited evidence, these medications warrant further investigation as potential modulators of corneal wound healing. Full article
(This article belongs to the Special Issue Advancements in Cornea Transplantation)
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