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Peptides with a Rationale: Smart Biomaterials for Biomedical Innovation

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials and Devices for Healthcare Applications".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 1836

Special Issue Editors


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Guest Editor
Department of Pharmacy, School of Medicine, University of Naples ‘Federico II’, Via Domenico Montesano 49, 80131 Naples, Italy
Interests: peptide chemistry; drug delivery; nanomaterials; anticancer peptide
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmacy, School of Medicine, University of Naples ‘Federico II’, Naples, Italy
Interests: peptide; dendrimer; nanomedicine; drug delivery; nanoparticle; self-assembled peptides
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Smart and adaptive, peptide-based biomaterials function as responsive systems that react and adapt to a range of physiological, chemical, and physical stimuli. Peptides can be designed and programmed to arrange into diverse supramolecular structures with different morphologies and dimensions. Peptide-based biomaterials are super-versatile due to their biocompatibility, tunability, and ability to mimic natural biological functions. Their main applications across biomedical fields include drug delivery, tissue engineering and regeneration, biosensing and diagnostics, antimicrobial coatings, and cancer therapy. This Special Issue will showcase design strategies and peptide chemistry approaches, detailed biophysical characterization, and in vitro and in vivo biological studies for developing innovative, application-specific biomaterials in the biomedical field with applications including neurological disorders, cancer treatment, and antibiotic resistance. We invite full papers, communications, and reviews covering topics related to the keywords below.

Dr. Rosa Bellavita
Prof. Dr. Stefania Galdiero
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • self-assembled peptides
  • peptide chemistry
  • drug delivery
  • nanomaterials
  • biomedical applications
  • theranostics

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Published Papers (1 paper)

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Review

37 pages, 2140 KB  
Review
Functional Peptide-Based Biomaterials for Pharmaceutical Application: Sequences, Mechanisms, and Optimization Strategies
by Dedong Yu, Nari Han, Hyejeong Son, Sun Jo Kim and Seho Kweon
J. Funct. Biomater. 2026, 17(1), 37; https://doi.org/10.3390/jfb17010037 - 13 Jan 2026
Viewed by 1542
Abstract
Peptide-based biomaterials have emerged as versatile tools for pharmaceutical drug delivery due to their biocompatibility and tunable sequences, yet a comprehensive overview of their categories, mechanisms, and optimization strategies remains lacking to guide clinical translation. This review systematically collates advances in peptide-based biomaterials, [...] Read more.
Peptide-based biomaterials have emerged as versatile tools for pharmaceutical drug delivery due to their biocompatibility and tunable sequences, yet a comprehensive overview of their categories, mechanisms, and optimization strategies remains lacking to guide clinical translation. This review systematically collates advances in peptide-based biomaterials, covering peptide excipients (cell penetrating peptides, tight junction modulating peptides, and peptide surfactants/stabilizers), self-assembling peptides (peptide-based nanospheres, cyclic peptide nanotubes, nanovesicles and micelles, peptide-based hydrogels and depots), and peptide linkers (for antibody drug-conjugates, peptide drug-conjugates, and prodrugs). We also dissect sequence-based optimization strategies, including rational design and biophysical optimization (cyclization, stapling, D-amino acid incorporation), functional motif integration, and combinatorial discovery with AI assistance, with examples spanning marketed drugs and research-stage candidates. The review reveals that cell-penetrating peptides enable efficient intracellular payload delivery via direct penetration or endocytosis; self-assembling peptides form diverse nanostructures for controlled release; and peptide linkers achieve site-specific drug release by responding to tumor-associated enzymes or pH cues, while sequence optimization enhances stability and targeting. Peptide-based biomaterials offer precise, biocompatible and tunable solutions for drug delivery, future advancements relying on AI-driven design and multi-functional modification will accelerate their transition from basic research to clinical application. Full article
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