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Functional Composite Biomaterials for Tissue Repair
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Functional Composite Biomaterials for Tissue Repair

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 3719

Special Issue Editors

Dr. Tianming Du

E-Mail Website
Guest Editor
Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China
Interests: biomaterials; biomechanics; biomineralization; bone repair; atherosclerosis
Prof. Dr. Aike Qiao

E-Mail Website
Guest Editor
Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China
Interests: biomechanics; cardiovascular intervention; structure design and mechanical analysis; hemodynamics; numerical simulation; medical devices; biomaterials; computer-aided surgical planning
Special Issues, Collections and Topics in MDPI journals
Dr. Fenghe Yang

E-Mail Website
Guest Editor
School of Pharmacy, Henan University, Kaifeng 475004, China
Interests: biomaterials; drug delivery; controlled release; bone and cartilage repair; immunomodulation

Special Issue Information

Dear Colleagues,

Due to the complexity and versatility of biological components, composite biomaterials have become an important research direction in the field of tissue repair. Composite materials can combine the advantages of multiple materials, meet the needs of mechanical properties, biocompatibility, tissue inducibility, biodegradability, and the antibacterial properties of materials in tissue repair processes, promote better and faster tissue repair, and play an important role in tissue repair. Recently, composite materials have made significant advancements in many fields, but their development in medicine requires interdisciplinary collaboration and further research.

This Special Issue "Functional Composite Biomaterials for Tissue Repair" aims to highlight recent progress in several widely studied application areas of functional composite biomaterials, promoting the development of composite biomaterials with comprehensive properties for biomedical applications. In this context, a wide range of topics will be discussed, including a new preparation process, new composite strategies, new composite mechanisms, multifunctional coupling strategies, new drug delivery strategies, biological effect evaluation, and biomedical applications. We hope that these topics will inspire new research and discoveries in the field of functional composite biomaterials for biomedical applications.

Dr. Tianming Du
Prof. Dr. Aike Qiao
Dr. Fenghe Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • composite
  • multifunctional
  • biomaterials
  • tissue repair
  • strategy
  • mechanism
  • application

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Published Papers (3 papers)

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Research

15 pages, 8322 KiB  
Article
Electrospun Silk Fibroin–Silk Sericin Scaffolds Induced Macrophage Polarization and Vascularization for Volumetric Muscle Loss Injury
by Yuqing Wang, Fangyu Ye, Xinbo Wei, Manman Wang, Zheng Xing and Haifeng Liu
J. Funct. Biomater. 2025, 16(2), 56; https://doi.org/10.3390/jfb16020056 - 10 Feb 2025
Viewed by 869
Abstract
Volumetric muscle loss (VML) results in the impediment of skeletal muscle function. Tissue engineering scaffolds have been widely developed and used in skeletal muscle regeneration. However, scaffold implantation causes an immune response that endogenously regulates implant integration and tissue regeneration. Moreover, vascularization is [...] Read more.
Volumetric muscle loss (VML) results in the impediment of skeletal muscle function. Tissue engineering scaffolds have been widely developed and used in skeletal muscle regeneration. However, scaffold implantation causes an immune response that endogenously regulates implant integration and tissue regeneration. Moreover, vascularization is thought to be a principal obstacle in the reconstruction of skeletal muscle defects. Thus, creating a pro-regenerative microenvironment that facilitates muscle regeneration and supports angiogenesis represents a promising strategy for tissue repair following volumetric muscle loss (VML) injury. Previously, the electrospun silk fibroin–silk sericin (SF-SS) film could regulate macrophage polarization and promote neovessel formation. This study aimed to investigate if the electrospun SF-SS scaffold was capable of supporting functional muscle regeneration. The results indicate that the conditioned medium collected from macrophages co-cultured with the 7:3 SF-SS scaffold significantly enhanced the proliferation and migration of myoblast C2C12 cells and improved the tube formation of HUVECs. Data from animal studies showed that the 7:3 SF-SS scaffold significantly enhanced M2 macrophage polarization, vascularization, and muscle fiber regeneration, reduced fibrosis, and improved muscle function after VML injury, thereby promoting the repair of muscle tissue. Therefore, the 7:3 SF-SS scaffold might represent a potential candidate for skeletal muscle regeneration following VML injury. Full article
(This article belongs to the Special Issue Functional Composite Biomaterials for Tissue Repair)
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15 pages, 5676 KiB  
Article
Dynamic-Cross-Linked, Regulated, and Controllable Mineralization Degree and Morphology of Collagen Biomineralization
by Ziyao Geng, Fan Xu, Ying Liu, Aike Qiao and Tianming Du
J. Funct. Biomater. 2024, 15(12), 356; https://doi.org/10.3390/jfb15120356 - 22 Nov 2024
Viewed by 946
Abstract
The cross-linking process of collagen is one of the more important ways to improve the mineralization ability of collagen. However, the regulatory effect of dynamic cross-linking on biomineralization in vitro remains unclear. Dynamic-cross-linked mineralized collagen under different cross-linking processes, according to the process [...] Read more.
The cross-linking process of collagen is one of the more important ways to improve the mineralization ability of collagen. However, the regulatory effect of dynamic cross-linking on biomineralization in vitro remains unclear. Dynamic-cross-linked mineralized collagen under different cross-linking processes, according to the process of cross-linking and mineralization of natural bone, was prepared in this study. Mineralization was performed for 12 h at 4, 8, and 12 h of collagen cross-linking. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) showed the characteristics of dynamic-cross-linked mineralization in terms of morphological transformation and distribution. Fourier transform infrared spectroscopy (FTIR) analysis showed the crystallinity characteristics of the hydroxyapatite (HA) crystal formation. Pre-cross-linked dynamic-cross-linked mineralization refers to the process of cross-linking for a period of time and then side cross-linked mineralization. The mineral content, enzyme stability, and mechanical properties of mineralized collagen were improved through a dynamic cross-linking process of pre-cross-linking. The swelling performance was reduced through the dynamic cross-linking process of pre-cross-linking. This study suggests that the dynamic cross-linking process through pre-cross-linking could make it easier for minerals to permeate and deposit between collagen fibers, improve mineralization efficiency, and, thus, enhance the mechanical strength of biomineralization. This study can provide new ideas and a theoretical basis for designing mineralized collagen scaffolds with better bone repair ability. Full article
(This article belongs to the Special Issue Functional Composite Biomaterials for Tissue Repair)
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14 pages, 4138 KiB  
Article
Comparison of Biomechanical and Microstructural Properties of Aortic Graft Materials in Aortic Repair Surgeries
by Haoliang Sun, Zirui Cheng, Xiaoya Guo, Hongcheng Gu, Dalin Tang and Liang Wang
J. Funct. Biomater. 2024, 15(9), 248; https://doi.org/10.3390/jfb15090248 - 28 Aug 2024
Viewed by 1283
Abstract
Mechanical mismatch between native aortas and aortic grafts can induce graft failure. This study aims to compare the mechanical and microstructural properties of different graft materials used in aortic repair surgeries with those of normal and dissected human ascending aortas. Five types of [...] Read more.
Mechanical mismatch between native aortas and aortic grafts can induce graft failure. This study aims to compare the mechanical and microstructural properties of different graft materials used in aortic repair surgeries with those of normal and dissected human ascending aortas. Five types of materials including normal aorta (n = 10), dissected aorta (n = 6), human pericardium (n = 8), bovine pericardium (n = 8) and Dacron graft (n = 5) were collected to perform uniaxial tensile testing to determine their material stiffness, and ultimate strength/stretch. The elastin and collagen contents in four tissue groups except for Dacron were quantified by histological examinations, while the material ultrastructure of five material groups was visualized by scanning electron microscope. Statistical results showed that three graft materials including Dacron, human pericardium and bovine pericardium had significantly higher ultimate strength and stiffness than both normal and dissected aortas. Human and bovine pericardia had significantly lower ultimate stretch than native aortas. Histological examinations revealed that normal and diseased aortic tissues had a significantly higher content of elastic fiber than two pericardial tissues, but less collagen fiber content. All four tissue groups exhibited lamellar fiber ultrastructure, with aortic tissues possessing thinner lamella. Dacron was composed of densely coalesced polyethylene terephthalate fibers in thick bundles. Aortic graft materials with denser fiber ultrastructure and/or higher content of collagen fiber than native aortic tissues, exhibited higher ultimate strength and stiffness. This information provides a basis to understand the mechanical failure of aortic grafts, and inspire the design of biomimetic aortic grafts. Full article
(This article belongs to the Special Issue Functional Composite Biomaterials for Tissue Repair)
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