Functional Composite Biomaterials for Tissue Repair

Special Issue Editors


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Guest Editor
Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China
Interests: biomaterials; biomechanics; biomineralization; bone repair; atherosclerosis

E-Mail Website
Guest Editor
Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China
Interests: biomechanics; cardiovascular intervention; structure design and mechanical analysis; hemodynamics; numerical simulation; medical devices; biomaterials; computer-aided surgical planning
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Guest Editor
School of Pharmacy, Henan University, Kaifeng 475004, China
Interests: biomaterials; drug delivery; controlled release; bone and cartilage repair; immunomodulation

Special Issue Information

Dear Colleagues,

Due to the complexity and versatility of biological components, composite biomaterials have become an important research direction in the field of tissue repair. Composite materials can combine the advantages of multiple materials, meet the needs of mechanical properties, biocompatibility, tissue inducibility, biodegradability, and the antibacterial properties of materials in tissue repair processes, promote better and faster tissue repair, and play an important role in tissue repair. Recently, composite materials have made significant advancements in many fields, but their development in medicine requires interdisciplinary collaboration and further research.

This Special Issue "Functional Composite Biomaterials for Tissue Repair" aims to highlight recent progress in several widely studied application areas of functional composite biomaterials, promoting the development of composite biomaterials with comprehensive properties for biomedical applications. In this context, a wide range of topics will be discussed, including a new preparation process, new composite strategies, new composite mechanisms, multifunctional coupling strategies, new drug delivery strategies, biological effect evaluation, and biomedical applications. We hope that these topics will inspire new research and discoveries in the field of functional composite biomaterials for biomedical applications.

Dr. Tianming Du
Prof. Dr. Aike Qiao
Dr. Fenghe Yang
Guest Editors

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Keywords

  • composite
  • multifunctional
  • biomaterials
  • tissue repair
  • strategy
  • mechanism
  • application

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Published Papers (1 paper)

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Research

14 pages, 4138 KiB  
Article
Comparison of Biomechanical and Microstructural Properties of Aortic Graft Materials in Aortic Repair Surgeries
by Haoliang Sun, Zirui Cheng, Xiaoya Guo, Hongcheng Gu, Dalin Tang and Liang Wang
J. Funct. Biomater. 2024, 15(9), 248; https://doi.org/10.3390/jfb15090248 - 28 Aug 2024
Viewed by 801
Abstract
Mechanical mismatch between native aortas and aortic grafts can induce graft failure. This study aims to compare the mechanical and microstructural properties of different graft materials used in aortic repair surgeries with those of normal and dissected human ascending aortas. Five types of [...] Read more.
Mechanical mismatch between native aortas and aortic grafts can induce graft failure. This study aims to compare the mechanical and microstructural properties of different graft materials used in aortic repair surgeries with those of normal and dissected human ascending aortas. Five types of materials including normal aorta (n = 10), dissected aorta (n = 6), human pericardium (n = 8), bovine pericardium (n = 8) and Dacron graft (n = 5) were collected to perform uniaxial tensile testing to determine their material stiffness, and ultimate strength/stretch. The elastin and collagen contents in four tissue groups except for Dacron were quantified by histological examinations, while the material ultrastructure of five material groups was visualized by scanning electron microscope. Statistical results showed that three graft materials including Dacron, human pericardium and bovine pericardium had significantly higher ultimate strength and stiffness than both normal and dissected aortas. Human and bovine pericardia had significantly lower ultimate stretch than native aortas. Histological examinations revealed that normal and diseased aortic tissues had a significantly higher content of elastic fiber than two pericardial tissues, but less collagen fiber content. All four tissue groups exhibited lamellar fiber ultrastructure, with aortic tissues possessing thinner lamella. Dacron was composed of densely coalesced polyethylene terephthalate fibers in thick bundles. Aortic graft materials with denser fiber ultrastructure and/or higher content of collagen fiber than native aortic tissues, exhibited higher ultimate strength and stiffness. This information provides a basis to understand the mechanical failure of aortic grafts, and inspire the design of biomimetic aortic grafts. Full article
(This article belongs to the Special Issue Functional Composite Biomaterials for Tissue Repair)
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