Advances in Biomaterials and Hydrogels: Pioneering Strategies for Brain Repair in Neurodegenerative Diseases and Aging

Special Issue Editors


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Guest Editor
1. Department of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, NY 115680-8000, USA
2. Experimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Interests: stroke; neuroinflammation; ageing; cell therapy; genomics; 3D-bioprinting; behavior analysis

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Guest Editor
Experimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Interests: microglia morphology; neurodegeneration; in vivo animal models

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Guest Editor
Department of Biochemistry, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Interests: stroke; EVs; oxidative stress; neuroinflammation; exosomes

Special Issue Information

Dear Colleagues,

The increasing prevalence of neurodegenerative diseases and age-related brain conditions, such as Alzheimer's disease, Parkinson's disease, and stroke, underscores the critical need for innovative therapeutic strategies. This Special Issue, entitled "Advances in Biomaterials and Hydrogels: Pioneering Strategies for Brain Repair in Neurodegenerative Diseases and Aging", is dedicated to advancing the understanding and application of biomaterials and hydrogels that promote neuroregeneration and functional recovery.

For this Special Issue, we welcome original research articles, reviews, and insightful perspectives that cover a broad spectrum of topics. These include the design and synthesis of biomaterials tailored for brain tissue engineering, the functionalization of hydrogels with bioactive molecules to enhance neuroregeneration, and both in vitro and in vivo evaluations of biomaterial efficacy in brain tissue repair following neurodegenerative damage. This Special Issue will also explore how biomaterials can modulate the brain's microenvironment and inflammatory responses, the advances in 3D bioprinting technologies for personalized brain implants, and the mechanisms through which hydrogels support neuroprotection and neuronal survival.

Furthermore, this Special Issue aims to navigate the challenges and opportunities in the clinical translation of these advanced materials. Contributions on comparative studies of different biomaterials and hydrogels, their efficacy in neuroregenerative applications, and innovative approaches that combine hydrogels with stem cell therapies, gene editing, and targeted drug delivery systems are highly encouraged. We are particularly interested in research that probes the long-term biocompatibility and biodegradability of hydrogels, their integration with existing neural networks, and their role in supporting functional recovery.

By highlighting cutting-edge developments and promoting interdisciplinary collaboration among physicians, materials scientists, regenerative medicine experts, and bioengineers, this Special Issue aims to provide an up-to-date view on pioneering strategies for brain repair in the context of neurodegenerative diseases and aging.

We acknowledge Dr. Alexandra Daniela Rotaru Zavaleanu's assistance in this Special Issue.

Dr. Andrei Gresita
Dr. Bogdan Catalin
Dr. Roxana Surugiu
Guest Editors

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Keywords

  • neurodegenerative diseases
  • aging
  • biomaterials
  • hydrogels
  • tissue engineering
  • neuroprotection
  • 3D bioprinting
  • 4D bioprinting
  • scaffolds

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Published Papers

This special issue is now open for submission.
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