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Biomaterials for Dental Reparative and Regenerative Therapies
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Biomaterials for Dental Reparative and Regenerative Therapies

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Dental Biomaterials".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 1519

Special Issue Editors

Dr. Rui Li

E-Mail Website
Guest Editor
Department of Prosthodontics, UConn School of Dental Medicine, Farmington, CT 06030, USA
Interests: dental implants; biomaterials; prosthodontics; biomechanics; CAD-CAM
Dr. Praveen R. Arany

E-Mail Website
Guest Editor
Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA
Interests: dental biomaterials; 3D printing; smart (control release, sense and respond); biomaterials systems; biointerfaces; biotechnologies (Lasers, radiofrequency)

Special Issue Information

Dear Colleagues,

Dental reparative and regenerative therapies represent an emerging and interdisciplinary field within restorative dentistry and tissue engineering. This area of study focuses on developing and applying advanced materials, cutting-edge techniques, and innovative biological approaches to restore the structure, function, and aesthetics of damaged or diseased dental tissues. It encompasses a wide range of restorative efforts, including the repair of teeth, dental pulp, periodontal structures, and surrounding bone, as well as the regeneration of tissues that have been compromised by trauma, decay, or disease.

The field integrates elements of biomaterial science, stem cell therapy, and regenerative medicine to harness the body's natural healing processes, aiming for superior clinical outcomes. Recent research in this domain covers the development of materials that can support the regeneration of dental pulp, the repair of enamel and dentin, bone augmentation for dental implantology, and the application of 3D printing and tissue engineering techniques to create customized, patient-specific solutions. The goal of this research is to achieve long-lasting, biologically compatible dental restorations that not only restore oral function but also promote the health and regeneration of natural dental tissues.

This Special Issue of the Journal of Functional Biomaterials, titled “Biomaterials for Dental Reparative and Regenerative Therapies”, seeks to bring together cutting-edge research and developments in this dynamic field.

Dr. Rui Li
Dr. Praveen R. Arany
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dental biomaterials
  • tissue engineering
  • 3D printing
  • nanomaterials
  • regenerative dentistry
  • dental implants
  • dental biomechanics

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Published Papers (2 papers)

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Research

15 pages, 1434 KB  
Article
Shear Bond Strength of Self-Adhesive and Self-Etching Resin Cements to Dentin for Indirect Restorations
by Janet Kirilova, Georgi Veselinov Iliev, Sevda Yantcheva, Elitsa Deliverska and Viktoria Petrova
J. Funct. Biomater. 2025, 16(8), 289; https://doi.org/10.3390/jfb16080289 - 12 Aug 2025
Viewed by 575
Abstract
This study assessed and compared the shear bond strength of self-adhesive and self-etching resin cements for indirect aesthetic restorations to dentin. Four different materials, lithium disilicate ceramics, zirconia ceramics, polymethyl methacrylate (PMMA) composites, and hybrid materials, were used for indirect restorations cemented to [...] Read more.
This study assessed and compared the shear bond strength of self-adhesive and self-etching resin cements for indirect aesthetic restorations to dentin. Four different materials, lithium disilicate ceramics, zirconia ceramics, polymethyl methacrylate (PMMA) composites, and hybrid materials, were used for indirect restorations cemented to dentin. The null hypothesis was that there would be no differences in shear bond strength between the investigated materials. Eighty extracted human molars were used. Eighty dentin specimens with a flat surface were prepared and randomly distributed in groups of 10 (n = 10). From each material (Cerasmart 270, Initial LiSi Blok, Katana ZR Noritake, and Crowntec Next Dent), 20 blocks were made and cemented to the dentin samples. Half of the blocks from each material were cemented to dentin using self-etching resin cement (Panavia V5), and the other half using self-adhesive resin cement (i-CEM). After the specimens were prepared, a laboratory test was conducted to evaluate the shear bond strength. The fracture type was determined using a light microscope, and SEM confirmed the results. The results were statistically analysed. All materials cemented with self-etching cements (Panavia V5) showed statistically higher shear strength values than those cemented with self-adhesive resin cement (i-CEM). In the specimen groups where self-adhesive cement (i-CEM) was used, Cerasmart 270 bonded statistically better. A statistical difference was found between all groups of materials cemented with self-etching cement. The Initial LiSi Block showed the strongest bond, followed by Katana Zr Noritake, Crowntec NextDent, and Cerasmart 270. Adhesion fracture to dentin was observed for all groups cemented with i-CEM. This study highlights the superior performance of self-etching cements in terms of shear bond strength. 10-Methacryloyloxydecyl dihydrogen phosphate (10-MDP), a functional monomer, was found to enhance adhesion strength significantly. However, using self-adhesive cements was associated with a weaker bond to dentin, highlighting the importance of the right cementing agent in restorative dentistry. Full article
(This article belongs to the Special Issue Biomaterials for Dental Reparative and Regenerative Therapies)
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13 pages, 1247 KB  
Article
Controlling Sodium Titanate Crystal Size to Improve Wettability and Early Osseointegration of Titanium Implants: Insights from an Animal Model
by Saray Fernández-Hernández, Javier Gil, Marta Sanjuán-Álvarez, Ignacio Sanz, Mariano Herrero-Climent and Aritza Brizuela-Velasco
J. Funct. Biomater. 2025, 16(8), 283; https://doi.org/10.3390/jfb16080283 - 1 Aug 2025
Viewed by 776
Abstract
The thermo-chemical treatment of dental implants leads to the formation of sodium titanate crystals on their surface. When in contact with blood, these crystals dissolve and trigger an ionic exchange cascade, resulting in the formation of a calcium apatite layer. This study, carried [...] Read more.
The thermo-chemical treatment of dental implants leads to the formation of sodium titanate crystals on their surface. When in contact with blood, these crystals dissolve and trigger an ionic exchange cascade, resulting in the formation of a calcium apatite layer. This study, carried out both in vitro and in an animal model, aimed to determine whether the cooling rate of the treatment affects the size of the deposited crystals, and whether this in turn influences wettability and early bone-to-implant contact (BIC). A total of 50 dental implants and 50 titanium discs were treated using four different cooling rates, along with a control group. Crystal size was analyzed on implant surfaces using scanning electron microscopy, and wettability was assessed on titanium discs using a goniometer. Finally, the implants were placed in the tibiae of 13 rabbits, and histological analysis was performed after three weeks to compare BIC among groups. Results suggest that a cooling rate of 75 °C/h produces smaller sodium titanate crystals, which are associated with significantly improved surface wettability and a higher percentage of bone-to-implant contact after 3 weeks of healing (p < 0.05). Full article
(This article belongs to the Special Issue Biomaterials for Dental Reparative and Regenerative Therapies)
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