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Antifungal Resistance Mechanisms from a One Health Perspective
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Antifungal Resistance Mechanisms from a One Health Perspective

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 608

Special Issue Editors

Dr. Felipe Queiroga Sarmento Guerra

E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil
Interests: antifungal resistance; antifungal susceptibility testing; antifungal therapy; One Health; phytopathology; laboratory diagnosis of mycosis
Dr. Edeltrudes O. Lima

E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil
Interests: antibacterial; antifungal

Special Issue Information

Dear Colleagues,

Fungal infections have become increasingly prominent in recent years, affecting approximately 1.7 billion people annually. Additionally, around 1.5 million invasive fungal infections (IFIs) have been reported, with high mortality rates. Currently, only four classes of systemic antifungal medications for IFIs are used in clinical practice; a few others are under development. Although effective antifungals are available, therapeutic failures continue to be reported, including the rise of antifungal-resistant strains. Mechanistically, antifungal resistance is typically acquired due to ineffective binding to drug targets and/or efflux activity. The One Health approach to mycology is an important and relevant framework for understanding and addressing complex health challenges, including mechanisms of antifungal resistance, at the intersection of human, animal, and environmental health.

This Special Issue seeks original research and review articles that contribute to the understanding of the mechanisms behind antifungal resistance from a One Health perspective. We invite researchers to submit both original research and review articles for this Special Issue.

Dr. Felipe Queiroga Sarmento Guerra
Dr. Edeltrudes O. Lima
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antifungal resistance
  • molecular mechanisms of resistance
  • One Health
  • environmental mycology
  • phytopalogy and zoonotic diseases

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Published Papers (1 paper)

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Research

16 pages, 2954 KiB  
Article
Analyses of the Genetic Diversity and Population Structures of Sporothrix spp. Clinical Isolates from Paraíba, Brazil
by Larissa Alves da Silva, Jamile Ambrósio de Carvalho, Luanna de Oliveira e Lima, Francisco Bernardino da Silva Neto, Edeltrudes de Oliveira Lima, Walicyranison Plínio da Silva Rocha, Zoilo Pires de Camargo, Anderson Messias Rodrigues, Ana Carolina Bernardes Dulgheroff and Felipe Queiroga Sarmento Guerra
J. Fungi 2024, 10(12), 848; https://doi.org/10.3390/jof10120848 - 9 Dec 2024
Viewed by 489
Abstract
Sporotrichosis is a subcutaneous mycosis of global distribution, capable of affecting both humans and animals, and caused by species of the genus Sporothrix spp. This study aimed to evaluate the genetic diversity and mating type distribution of clinical isolates of human sporotrichosis in [...] Read more.
Sporotrichosis is a subcutaneous mycosis of global distribution, capable of affecting both humans and animals, and caused by species of the genus Sporothrix spp. This study aimed to evaluate the genetic diversity and mating type distribution of clinical isolates of human sporotrichosis in Paraíba, Brazil, to better understand the population structure, epidemiology, and diversification of this pathogen, as well as to explore possible transmission routes. Methods: A total of 36 clinical isolates were morphologically identified, and clinical and demographic data were collected. Fungal DNA extraction was then performed, followed by species-specific PCR using markers targeting the calmodulin gene. The mating type idiomorph of the species was identified by PCR using primers targeting the MAT1-1 and MAT1-2 loci. Amplified Fragment Length Polymorphism (AFLP) was used to evaluate the genetic variability of Sporothrix spp. Results: The distribution of the disease identified that all cases occurred in João Pessoa and adjacent cities. From the 36 isolates, the majority (75%) being affected females, a prevalent occurrence of the lymphocutaneous form, and 98% zoonotic transmission were confirmed. Micro- and macromorphological structures were similar to each other, confirming Sporothrix spp. All isolates were confirmed as S. brasiliensis and the presence of a single sexual idiomorph, MAT1-2, was detected. The AFLP results indicate the possibility of the circulation of one or two genetic groups in João Pessoa and the metropolitan region. Conclusions: To our knowledge, this is the first time isolates in the Paraíba state are genetically characterised, all identified as Sporothrix brasiliensis. It is likely that this species in Paraiba originated from Rio de Janeiro, as all they possess the MAT1-2 idiomorph, indicating low intergenotypic variation. Full article
(This article belongs to the Special Issue Antifungal Resistance Mechanisms from a One Health Perspective)
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