Bioinformatics and Current Techniques in Medical Mycology: Combining Laboratory and Clinical Viewpoints

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: closed (31 August 2025) | Viewed by 1757

Special Issue Editors


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Guest Editor
Mycological Laboratory, Department of Plant Physiology, Institute for Biological Research "Siniša Stanković"—National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia
Interests: pathogenic fungi; mushrooms; mycomedicines; natural products; dermatomycetes
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Special Issue Information

Dear Colleagues,

In terms of diagnosis, treatment, and research, medical mycology is a dynamic discipline that has been confronted with both novel challenges and fascinating future prospects. The goal of this Special Issue is to offer a comprehensive forum covering the full range of fungal infections, from invasive and systemic illnesses to superficial and cutaneous types. Bioinformatics plays a crucial role in fungal epidemiology and retrospective analysis by enabling real-time tracking of outbreaks and resistance surveillance; these methods improve public health responses, increase early identification, and guide antifungal treatment plans. In addition to cutting-edge research on diagnostic advancements, antifungal resistance, treatment approaches, host–pathogen interactions, and public health consequences, the issue will welcome retrospective analyses as well. This issue aims to improve our knowledge of fungal infections and promote interdisciplinary collaborations by connecting clinical findings with laboratory research. The SI idea is to establish a feedback loop in which laboratory findings are quickly and successfully applied in clinical settings, improving patient outcomes and furthering the field of medical mycology, while clinical challenges serve as inspiration for laboratory and computational research.

Case reports, brief communications, thorough reviews, and original research articles are all welcome in this Special Issue. Mycologists, microbiologists, infectious disease specialists, and clinicians are welcome to submit their work, in order to offer a comprehensive perspective on the present and potential future paths of medical mycology.

Aims and Scope:

  • Trends in epidemiology—monitoring and bioinformatic tools in fungal infections;
  • Diagnostic developments—new methods and difficulties in identifying fungi;
  • Mechanisms, clinical consequences, and management approaches of and for antifungal resistance;
  • Innovations in therapeutics—drug development and novel therapeutic approaches in antifungal therapy;
  • Clinical analyses—both prospective and retrospective research, including series and case reports;
  • Pathophysiology and reaction of the host—Molecular discoveries and immunological aspects of fungal infections;
  • Multidisciplinary viewpoints—Combining laboratory and translational research with clinical data.

Dr. Dejan Stojković
Dr. Ana Ćirić
Guest Editors

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Keywords

  • medical mycology
  • fungal infections
  • antifungal resistance
  • bioinformatics in mycology
  • diagnostic advancements
  • host–pathogen interactions
  • antifungal therapy
  • epidemiology of fungal diseases
  • translational mycology
  • clinical mycology

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Published Papers (2 papers)

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17 pages, 1515 KB  
Article
Five-Year Retrospective Analysis of Superficial Fungal Infections: Insights from Hospital Experience
by Nikoleta Đorđevski, Elizabeta Ristanović, Ana Ćirić, Diana Tomić, Biljana Nikolić, Nemanja Rajčević and Dejan Stojković
J. Fungi 2025, 11(7), 474; https://doi.org/10.3390/jof11070474 - 22 Jun 2025
Viewed by 900
Abstract
This study aimed to assess the incidence and distribution of dermatomycetes in patients at the Medical Military Academy (MMA) with suspected superficial skin infections over a five-year period (October 2017 to October 2022) and to analyze variations in fungal infections based on factors [...] Read more.
This study aimed to assess the incidence and distribution of dermatomycetes in patients at the Medical Military Academy (MMA) with suspected superficial skin infections over a five-year period (October 2017 to October 2022) and to analyze variations in fungal infections based on factors such as gender, body part, and time, particularly influenced by the COVID-19 pandemic. A total of 3993 samples were analyzed. Collected data were statistically analyzed with two tests. A total of 1048 samples were positive for fungal infections. Over the study period, Trichophyton mentagrophytes and Trichophyton rubrum were the predominant taxa, while Microsporum canis and Candida albicans were frequently observed. Statistical analysis indicated significant annual variations for T. mentagrophytes, T. rubrum, and M. canis, with monthly differences for T. mentagrophytes in June and August and M. canis in October and December. Gender-based analysis showed that T. rubrum and T. mentagrophytes were more common in males, while M. canis, C. albicans, Candida spp., and Geotrichum candidum were more prevalent in females. Analysis by body part revealed that Trichophyton rubrum and Microsporum canis showed significant differences between surface types. These findings can help improve diagnostic, therapeutic, and preventative strategies. Full article
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7 pages, 894 KB  
Commentary
Advancing Peptide-Based Vaccines Against Candida: A Comparative Perspective on Liposomal and Synthetic Formulations
by Hong Xin
J. Fungi 2025, 11(10), 715; https://doi.org/10.3390/jof11100715 - 2 Oct 2025
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Abstract
The growing threat of multidrug-resistant fungal pathogens, especially Candida auris, has underscored the need for effective antifungal vaccines. This commentary highlights recent advances in peptide-based vaccination using the SNAP (Spontaneous Nanoliposome Antigen Presentation) platform, focusing on the FM-SNAP vaccine, a bivalent liposomal [...] Read more.
The growing threat of multidrug-resistant fungal pathogens, especially Candida auris, has underscored the need for effective antifungal vaccines. This commentary highlights recent advances in peptide-based vaccination using the SNAP (Spontaneous Nanoliposome Antigen Presentation) platform, focusing on the FM-SNAP vaccine, a bivalent liposomal formulation targeting the surface-expressed peptides fructose bisphosphate aldolase (Fba) and methionine synthase (Met6). Compared to earlier constructs such as MP12, FM-SNAP achieves superior immunogenicity and long-lasting protection at lower antigen doses. It elicits balanced Th1/Th2 cytokine responses and demonstrates durable efficacy in both immunocompetent and complement-deficient mouse models. The platform’s compatibility with clinically approved adjuvants (MPLA and QS-21), modular peptide design, and potential for multi-pathogen applications underscores its translational promise. FM-SNAP exemplifies a next-generation vaccine strategy that is both scalable and adaptable for high-risk immunocompromised populations. Full article
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