Novel, Emerging and Neglected Fungal Pathogens for Humans

A special issue of Journal of Fungi (ISSN 2309-608X).

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1352

Special Issue Editor


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Guest Editor

Special Issue Information

Dear Colleagues,

An increasing number of fungal species are recognized as being pathogenic to humans. One of the reasons for this trend is that clinical fungi can now be more accurately identified using molecular technologies. Therefore, fungi previously uncommonly encountered can now be recognized as causes of infections. Unknown fungi of clinical origin can also be characterized via genealogical concordance approaches and described as novel species. A notable example is the recognition of the yeast Candida auris as a species distinct from Candida haemulonii and Candida ruelliae, and it is now notorious for its persistence in the environment, as well as its multi-drug-resistant properties. Knowledge of these novel, emerging and/or neglected fungal pathogens is unfortunately lacking; thus, more research into them is needed.

In this Special Issue, we invite researchers to contribute original research and review articles on novel, emerging and neglected fungal pathogens that affect humans. Topics of interest include, but are not limited to, the following subjects:

  • Description of novel human pathogenic fungal species;
  • Pathogenesis or virulence;
  • Antifungal susceptibility and resistance;
  • Epidemiology;
  • Diagnostic methods;
  • Any other relevant areas.

Dr. Chi-Ching Tsang
Guest Editor

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Keywords

  • description of novel human pathogenic fungal species
  • pathogenesis or virulence
  • antifungal susceptibility and resistance
  • epidemiology
  • diagnostic methods
  • any other relevant areas

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Published Papers (1 paper)

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15 pages, 1754 KiB  
Systematic Review
Diversity and Distribution of Fungal Infections in Rwanda: High Risk and Gaps in Knowledge, Policy, and Interventions
by Claude Mambo Muvunyi, Jean Claude Semuto Ngabonziza, Masaisa Florence, Isabelle Mukagatare, Marc Twagirumukiza, Ayman Ahmed and Emmanuel Edwar Siddig
J. Fungi 2024, 10(9), 658; https://doi.org/10.3390/jof10090658 - 18 Sep 2024
Cited by 1 | Viewed by 952
Abstract
Fungal infections (FIs) are spreading globally, raising a significant public health concern. However, its documentation remains sparse in Africa, particularly in Rwanda. This report provides a comprehensive review of FIs in Rwanda based on a systematic review of reports published between 1972 and [...] Read more.
Fungal infections (FIs) are spreading globally, raising a significant public health concern. However, its documentation remains sparse in Africa, particularly in Rwanda. This report provides a comprehensive review of FIs in Rwanda based on a systematic review of reports published between 1972 and 2022. The findings reveal a rich diversity of fungal pathogens, including Blastomyces, Candida, Cryptococcus, Histoplasma, Microsporum, Pneumocystis, Rhinosporidium, and Trichophyton caused human infections. Candida infections predominantly affect the vagina mucosa, while Histoplasma duboisi was linked to disseminated infections. Other pathogens, such as Blastomyces dermatitidis and Rhinosporidium seeberi, were associated with cerebellar and nasal mucosa infections, respectively. The widespread observation of soilborne fungi affecting bean crops highlights the pathogens’ threat to agricultural productivity, food security, and socioeconomic stability, as well as potential health impacts on humans, animals, and the environment. Of particular importance is that there is no information about FIs among animals in the country. Moreover, the analysis underscores significant limitations in the detection, reporting, and healthcare services related to FIs in the country, indicating gaps in diagnostic capacity and surveillance systems. This is underscored by the predominant use of traditional diagnostic techniques, including culture, cytology, and histopathology in the absence of integrating more sensitive and specific molecular tools in investigating FIs. Developing the diagnostic capacities and national surveillance systems are urgently needed to improve the health of crops, animals, and humans, as well as food security and socioeconomic stability in Rwanda. Also, it is important to indicate severe gaps in the evidence to inform policymaking, guide strategic planning, and improve healthcare and public health services, underscoring the urgent need to build national capacity in fungal diagnosis, surveillance, and research. Raising awareness among the public, scientific community, healthcare providers, and policymakers remains crucial. Furthermore, this report reveals the threats of FIs on public health and food insecurity in Rwanda. A multisectoral one health strategy is essential in research and intervention to determine and reduce the health and safety impacts of fungal pathogens on humans, animals, and the environment. Full article
(This article belongs to the Special Issue Novel, Emerging and Neglected Fungal Pathogens for Humans)
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