Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.7
4.2
Journals
JoF
Special Issues
Natural Antifungal Agents
share announcement

Natural Antifungal Agents

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Cell Biology, Metabolism and Physiology".

Deadline for manuscript submissions: closed (30 July 2023) | Viewed by 2439

Special Issue Editor

Dr. Giovanna Simonetti

E-Mail Website
Guest Editor
Department of Environmental Biology, “Sapienza” University of Rome, Rome, Italy
Interests: antimicrobials; molds; yeasts; antimicrobial resistance; biofilm
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Fungi are the highest threat for animal–host and plant–host species. Over one billion people suffer from severe fungal diseases. Bats, amphibians, and reptiles are threatened with extinction by animal pathogenic fungi. Plants and crops are also damaged by fungal diseases. In addition, there is an increase in emerging pathogens and resistance to antifungal drugs. The need to identify new safe agents to reduce the global burden of fungal diseases has prompted the study of plant products as a source of new and effective antifungal agents. Plant products represent a nearly unlimited source of active ingredients. The antifungal activity of some plant extracts against human and plant fungal pathogens has been demonstrated. 

In this context, studies focusing on exploring the activity of plant products on the growth and on the virulence factors of human/animal/plant pathogenic fungi are required.

Plant products could be used to improve the efficacy of conventional antimicrobials, to decrease their adverse effects, and to reverse drug resistance. Selected plant compounds could be also used as templates for the development of new scaffolds of drugs.

Dr. Giovanna Simonetti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant products
  • antifungal agents
  • fungal biofilm
  • virulence factors
  • crop protection
  • drug delivery systems
  • epigenetic activity
  • synergy activity
  • in vitro and in vivo studies

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

14 pages, 2588 KiB  
Article
Anti-Candida Potential of Sclareol in Inhibiting Growth, Biofilm Formation, and Yeast–Hyphal Transition
by Chaerim Kim, Jae-Goo Kim and Ki-Young Kim
J. Fungi 2023, 9(1), 98; https://doi.org/10.3390/jof9010098 - 10 Jan 2023
Cited by 6 | Viewed by 1963
Abstract
Even though Candida albicans commonly colonizes on most mucosal surfaces including the vaginal and gastrointestinal tract, it can cause candidiasis as an opportunistic infectious fungus. The emergence of resistant Candida strains and the toxicity of anti-fungal agents have encouraged the development of new [...] Read more.
Even though Candida albicans commonly colonizes on most mucosal surfaces including the vaginal and gastrointestinal tract, it can cause candidiasis as an opportunistic infectious fungus. The emergence of resistant Candida strains and the toxicity of anti-fungal agents have encouraged the development of new classes of potential anti-fungal agents. Sclareol, a labdane-type diterpene, showed anti-Candida activity with a minimum inhibitory concentration of 50 μg/mL in 24 h based on a microdilution anti-fungal susceptibility test. Cell membrane permeability with propidium iodide staining and mitochondrial membrane potential with JC-1 staining were increased in C. albicans by treatment of sclareol. Sclareol also suppressed the hyphal formation of C. albicans in both liquid and solid media, and reduced biofilm formation. Taken together, sclareol induces an apoptosis-like cell death against Candida spp. and suppressed biofilm and hyphal formation in C. albicans. Sclareol is of high interest as a novel anti-fungal agent and anti-virulence factor. Full article
(This article belongs to the Special Issue Natural Antifungal Agents)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop