Multidrug-Resistant Fungi, 2nd Edition
A special issue of Journal of Fungi (ISSN 2309-608X).
Deadline for manuscript submissions: 31 January 2025 | Viewed by 182
Special Issue Editor
Interests: multidrug resistance; fungi; antifungal; efflux pumps; ATPase
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The multidrug resistance (MDR) phenotype is the major factor responsible for the failure of antifungal therapy, increasing the length of hospital stay, treatment’s cost, and death rate. The main mechanisms of antifungal resistance are related to: 1) the presence of transporter proteins in the plasma membrane, extruding drugs from the intracellular milieu and therefore preventing them from reaching the necessary concentration which would allow them to be effective against the fungi; and 2) biofilm production. Nonetheless, other mechanisms may be observed, such as point mutations at ERG11 and FKS. Due to the importance of MDR to public health, the discovery of new molecules able to inhibit efflux transporters and/or disrupt biofilms emerges as a promising strategy for strengthening the antifungal arsenal. This Special Issue aims to feature and promote research regarding drugs that block the multidrug resistance phenotype.
Prof. Dr. Antônio Ferreira-Pereira
Guest Editor
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Keywords
- antimicrobial resistance
- efflux pumps
- multidrug resistance
- antifungal
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Related Special Issue
- Multidrug-Resistant Fungi in Journal of Fungi (9 articles)
