Advances in Bioactive Compounds from Marine Fungi

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungi in Agriculture and Biotechnology".

Deadline for manuscript submissions: closed (1 May 2024) | Viewed by 2335

Special Issue Editors


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Guest Editor
Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Xiamen University, Xiamen 361102, China
Interests: sea-derived fungus; metabolism; bioactive compounds

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Guest Editor
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China
Interests: marine drugs; deep-sea-derived microorganisms; fungi; secondary metabolites; bioactive compounds
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Special Issue Information

Dear Colleagues,

Marine fungi are a promising source of biologically active and structurally diverse secondary metabolites and have provided drug leads for the treatment of numerous diseases. However, the potential of marine natural products (MNPs) as effective drugs for osteoporosis treatment is an understudied area. Additionally, very few osteoblast differentiation promotors have been isolated from natural sources. Therefore, the identification of bioactive small molecules that target osteoblasts represents a new direction in the search for antiosteoporosis candidate drugs. This Special Issue will collect manuscripts that highlight the antiosteoporosis activities or mechanism of new secondary metabolites from deep-sea-derived marine fungi. Original research articles, reviews, and communications are welcome.

Dr. Chun-Lan Xie
Prof. Dr. Xian-Wen Yang
Guest Editors

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Keywords

  • marine fungus
  • structural identification
  • bioactive natural product
  • bone formation
  • osteoporosis
  • molecular mechanisms

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Published Papers (1 paper)

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Research

13 pages, 2442 KiB  
Article
Antibacterial Polyketides Isolated from the Marine-Derived Fungus Fusarium solani 8388
by Cankai Lin, Rongchun Huang, Juntao Liu, Hong Li, Liping Zhu, Xin Huang, Bo Ding, Lan Liu, Hongbo Huang and Yiwen Tao
J. Fungi 2023, 9(9), 875; https://doi.org/10.3390/jof9090875 - 24 Aug 2023
Cited by 3 | Viewed by 1777
Abstract
Seven new polyketides named fusarisolins F-K (16) and fusarin I (7) were isolated from the marine-derived fungus Fusarium solani 8388, together with the known anhydrojavanicin (8), 5-deoxybostry coidin (9), and scytalol A (10 [...] Read more.
Seven new polyketides named fusarisolins F-K (16) and fusarin I (7) were isolated from the marine-derived fungus Fusarium solani 8388, together with the known anhydrojavanicin (8), 5-deoxybostry coidin (9), and scytalol A (10). Their structures were established by comprehensive spectroscopic data analyses, and by comparison of the 1H and 13C NMR data with those reported in literature. Fusarisolin F (1) contained both a dichlorobenzene group and an ethylene oxide unit, which was rare in nature. In the bioassays, fusarisolin I (4), fusarisolin J (5), and 5-deoxybostry coidin (9) exhibited obvious antibacterial activities against methicillin-resistant Staphylococcus aureus n315 with MIC values of 3, 3, and 6 μg/mL, respectively. Fusarisolin H (3) and fusarisolin J (5) showed inhibitory effects against methicillin-resistant Staphylococcus aureus NCTC 10442 with the same MIC value of 6 μg/mL. With the exception of 5, all other compounds did not show or showed weak cytotoxicities against HeLa, A549, and KB cells; while fusarisolin J (5) demonstrated moderate cytotoxicities against the three human cancer cell lines with CC50 values between 9.21 and 14.02 μM. Full article
(This article belongs to the Special Issue Advances in Bioactive Compounds from Marine Fungi)
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