Xenobiotic Metabolism in Healthy Ageing
A special issue of Journal of Xenobiotics (ISSN 2039-4713). This special issue belongs to the section "Emerging Chemicals".
Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 466
Special Issue Editor
Special Issue Information
Dear Colleagues,
During ageing, organisms undergo a decline in function and homeostasis, accompanied by reduced cellular, organ, and systemic performance. Nevertheless, ageing can be modulated by environmental and genetic factors, and several pathways have been implicated in lifespan extension that are conserved from simple organisms to mammals. Among them are dietary restriction, reduced insulin/IGF signaling, reduced mitochondrial respiration, and signals from the reproductive system, which trigger natural defense mechanisms that help stave off ageing.
In line with this, organisms are constantly exposed to a variety of potentially toxic or harmful compounds of exogenous (drugs, environmental contaminants, dietary compounds, and food additives) or endogenous (metabolites and small molecules) origin. Recent studies suggest that the upregulation of xenobiotic metabolism, which is composed of a wide number of enzymes and transporters that function in the detoxification and elimination of potentially harmful molecules, may be another form of enhanced stress resistance shared between long-lived mutants across diverse taxa.
This Special Issue of the Journal of Xenobiotics intends to summarize the recent research focused on the alteration of xenobiotic metabolism, with an emphasis on its impact on healthy ageing.
Papers focused on xenobiotic metabolism during the ageing process and metabolic intervention in ageing using small molecules are welcomed.
Dr. Andrea Annibal
Guest Editor
Manuscript Submission Information
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Keywords
- Metabolism
- Ageing
- Gene expression
- Xenobiotic metabolism
- Longevity
- Model organism
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