Exploiting Metabolic Weaknesses: A Novel Approach to Overcome Drug Resistance in Cancer Therapy
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".
Deadline for manuscript submissions: 25 January 2025 | Viewed by 137
Special Issue Editor
2. Department of Surgery, Cardiothoracic Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA
Interests: tumor metabolism; immunometabolism; drug resistance; lung cancer; reactive oxygen species (ROS)
Special Issue Information
Dear Colleagues,
Cancer cells are known to rewire their metabolic pathways to rely heavily on glycolysis, a process that promotes their growth, survival, and proliferation. This seminal observation, made over 100 years ago by Otto Warburg, is recognized as the first significant metabolic shift in cancer cell survival. However, evidence suggests that cancer cells undergo further metabolic reprogramming when they develop resistance. This reprogramming shifts their reliance towards oxidative metabolism (OXMET) and relies on other carbon skeleton sources, such as glutamine, to survive. By utilizing amino acids instead of glucose, tumor cells reduce their proliferation rate, which helps them evade the effects of chemotherapies targeting rapidly dividing cells. Moreover, cellular metabolism also plays a crucial role in diminishing the immune cell's ability to inhibit tumor growth. Immune cells face a metabolic disadvantage due to a lack of carbon nutrients, which results from competition with tumor cells in the tumor microenvironment (TME).
By understanding how cellular metabolism influences cancer cells, we aim to identify strategies to circumvent resistance and improve cancer treatment. This Special Issue of the Journal of Personalized Medicine aims to highlight the latest studies in the field of tumor metabolism as well as tumor immunometabolism. Topics of interest include novel insights into metabolomics, metabolites, metabolic pathways/immune functions, inflammation/metabolism, and therapeutic implications.
Dr. Medhi Wangpaichitr
Guest Editor
Manuscript Submission Information
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Keywords
- drug resistance
- tumor metabolism
- immunometabolism
- metabolomics
- metabolites
- precision medicine
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