Neurologic Injury and Neurodegeneration

A special issue of Journal of Vascular Diseases (ISSN 2813-2475). This special issue belongs to the section "Neurovascular Diseases".

Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 743

Special Issue Editors


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Guest Editor
Department of Neurosurgery, University of Florida, Gainesville, FL, USA
Interests: neurosurgery; neuroscience; brain cancer; subarachnoid hemorrhage; traumatic brain injury

Special Issue Information

Dear Colleagues,

The Special Issue, “Neurologic Injury and Neurodegeneration”, aims to provide an opportunity for readers to dive deep into this subject. Central nervous system neurons are lost as a result of neurodegenerative diseases. Neurodegenerative diseases can have various causes, such as neurotrauma, stroke, epilepsy, encephalitis, and metabolic disease. Traumatic brain injury (TBI)  and concussion affect 42 million people worldwide every year, with TBI being a recognized risk factor for various neurodegenerative diseases. These two processes are, however, not fully understood in terms of their pathological mechanisms. The disruption of axonal transport and axonal injury in TBI influence molecular mechanisms, leading to the formation of pathological proteins, such as amyloid-β peptide and hyperphosphorylated tau. Research shows that neuroinflammation is a crucial pathological cause of chronic neurodegeneration following TBI. Microglia play important roles in neuroinflammation and related diseases of the central nervous system. Researchers hope that future research in this field will lead to a better understanding of the role of neuroinflammation in the pathophysiology of neurodegenerative diseases, which will later translate into the discovery of therapeutic targets. For this reason, we invite submissions of experimental and clinical results and literature reviews. There is no length restriction for papers. Where possible, full experimental and methodological details must be provided.

Dr. Brandon Lucke-Wold
Dr. Mohammad-Reza Hosseini-Siyanaki
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Vascular Diseases is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • traumatic brain injury
  • neurotrauma
  • concussion
  • neuroinflammation
  • anti-inflammatory
  • neurodegeneration
  • microglia

Published Papers (1 paper)

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Review

18 pages, 667 KiB  
Review
The Comorbidity and Associations between Depression, Cognitive Impairment, and Sleep after Stroke and How They Affect Outcomes: A Scoping Review of the Literature
by Lai Gwen Chan
J. Vasc. Dis. 2024, 3(2), 134-151; https://doi.org/10.3390/jvd3020012 - 1 Apr 2024
Viewed by 398
Abstract
Objectives: post-stroke depression (PSD), cognitive impairment, and sleep disturbances are the most common post-stroke conditions. To aid clinical practice for a highly confounded clinical problem, a clearer understanding of the associations between comorbid PSD, post-stroke cognitive impairment, and sleep disturbances is necessary. Materials [...] Read more.
Objectives: post-stroke depression (PSD), cognitive impairment, and sleep disturbances are the most common post-stroke conditions. To aid clinical practice for a highly confounded clinical problem, a clearer understanding of the associations between comorbid PSD, post-stroke cognitive impairment, and sleep disturbances is necessary. Materials and Methods: a scoping review of the literature was conducted according to the recommended guidelines using the search term [“stroke (mesh term) AND depression (in the abstract) AND cognitive (in the abstract) AND sleep (in the abstract)”]. Results: 10 studies met the criteria for inclusion. Only one study reported a co-occurrence of post-stroke emotional distress and sleep disturbances at a rate of 10.7%. Poor sleep and cognitive impairment are independent risk factors for PSD. The relationship between post-stroke poor sleep and cognitive impairment is ambiguous. None of the studies examined how PSD, cognitive impairment, and sleep disturbances interact to influence stroke outcomes. Conclusions: the dearth of studies indicates either a lack of awareness of the potential relationship between the three outcomes and the possible range of inter-related non-motor outcomes after stroke or the practical challenges in designing appropriate studies. The included studies had methodological weaknesses in their observational design and use of imprecise, subjective outcome measurements. Important knowledge gaps are identified for future research. Full article
(This article belongs to the Special Issue Neurologic Injury and Neurodegeneration)
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