Research Advances in Blood Purification: New Techniques, Drugs and Indications

A special issue of Kidney and Dialysis (ISSN 2673-8236).

Deadline for manuscript submissions: 31 July 2025 | Viewed by 839

Special Issue Editors

Renal Division, Peking University Shenzhen Hospital, Shenzhen 518036, China
Interests: chronic kidney disease; peritoneal dialysis; blood purification; peritonitis
Division of Renal Medicine, Peking University Shenzhen Hospital, Shenzhen, China
Interests: renal medicine

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Guest Editor
Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Peking University, Shenzhen 518036, China
Interests: lupus nephritis; dialysis; chronic kidney disease; inflammation

Special Issue Information

Dear Colleagues,

Blood purification is an extracorporeal therapeutic modality that facilitates the removal of deleterious substances from the human body via extracorporeal circulation, with the goals of the treatment and maintenance of fluid balance. The principal patient populations that benefit from this technology include those with renal disorders (such as end-stage chronic kidney disease or acute renal failure), individuals suffering from poisoning (due to drugs or heavy metals), patients with metabolic disorders (such as hyperuricemia or hypercholesterolemia), and individuals with immune-mediated diseases (including systemic lupus erythematosus or myasthenia gravis). Moreover, blood purification therapy may be indicated for patients with hepatic failure, severe infectious diseases, and stress-related injuries. Ongoing refinements in blood purification technologies have significantly enhanced patient outcomes and extended life expectancies. These advancements encompass improvements in blood purification machinery and materials, the optimization of vascular access techniques, the introduction of innovative blood purification methods, and the development of personalized treatment plans. However, both short-term and long-term blood purification treatments entail risks of adverse effects, which underscore the importance of the vigilant prevention and management of related complications. Furthermore, advancements in artificial organ and cell transplantation have opened new avenues of research within the realm of blood purification. Given its proven clinical efficacy, the application of blood purification technology has been broadened to encompass an array of additional indications. In summary, blood purification technology is in a state of perpetual evolution, striving for enhanced safety, improved efficacy, and greater personalization, thereby offering superior treatment options for a wide range of severe medical conditions.

This topic is dedicated to clinical research concerning novel technologies, pharmacotherapies, and the associated complications of blood purification. Submissions that focus on cutting-edge research regarding artificial kidney and cell transplantation techniques are also encouraged, as are discussions on the application of blood purification methodologies to emerging indications. The topics of interest include, but are not limited to, the following areas:

  1. Personalized blood purification solutions.
  2. Risk of infection, coagulation, and other complications during blood purification.
  3. Health effects of long-term blood purification and management practices.
  4. Current status of development of artificial kidney and cell transplantation techniques.
  5. Blood purification techniques in new indications.
  6. Dialysis and nutritional support.
  7. The effects of dialysis on drug metabolism and recommendations for safe use.

Dr. Zibo Xiong
Dr. Guang Yang
Dr. Fengping Zheng
Guest Editors

Manuscript Submission Information

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Keywords

  • chronic kidney disease
  • acute kidney disease
  • dialysis
  • vascular access
  • nursing
  • sepsis

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Published Papers (1 paper)

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15 pages, 1589 KiB  
Article
Chronobiological Changes in Biochemical Hemorrheological Parameters and Cytokine Levels in the Blood of Diabetic Patients on Hemodialysis: A Cross-Sectional Study
by Fernando A. Lima, Juliana S. Monção, Mariana S. Honorio, Mahmi Fujimori, Danielle C. H. França, Aron C. M. Cotrim, Emanuelle C. H. França, Aline C. França-Botelho, Danny Laura G. Fagundes-Triches, Patrícia G. F. Marchi, Adenilda C. Honorio-França and Eduardo L. França
Kidney Dial. 2025, 5(1), 9; https://doi.org/10.3390/kidneydial5010009 - 3 Mar 2025
Viewed by 329
Abstract
Introduction: Diabetes mellitus, a chronic disease characterized by hyperglycemia, is a significant contributor to chronic kidney disease, particularly in patients with diabetic nephropathy undergoing renal replacement therapy. Variations in circadian rhythms can influence the progression of chronic diseases and treatment outcomes. Aims: This [...] Read more.
Introduction: Diabetes mellitus, a chronic disease characterized by hyperglycemia, is a significant contributor to chronic kidney disease, particularly in patients with diabetic nephropathy undergoing renal replacement therapy. Variations in circadian rhythms can influence the progression of chronic diseases and treatment outcomes. Aims: This observational study evaluated gender-based chronobiological changes in biochemical, hemorheological factors, and cytokines in patients with dialysis-dependent diabetic nephropathy. Materials and Methods: A cross-sectional study was conducted in Barra do Garças, Brazil, involving 46 patients with type 2 diabetes mellitus who were on regular hemodialysis. Participants were divided into four groups for analysis according to gender and period of day. Inclusion criteria included individuals with type 2 diabetes mellitus undergoing periodic hemodialysis, receiving hemodialysis care at the service, and signing a consent form. Patients with an age under 18 years, diabetes mellitus type 1, or with autoimmune diseases were excluded. Blood samples were collected to assess melatonin, cortisol, biochemical and hemorheological parameters, and cytokines such as IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, and IL-17. Results: Men exhibited higher melatonin, urea, and creatinine levels in the morning and afternoon phases. At the same time, women showed lower melatonin, increased viscosity, and a decreased deformation rate in the afternoon. Additionally, levels of TNF-α, IFN-γ, and IL-17 were lower in morning serum samples from women. Conclusion: These findings suggest that both gender and circadian timing should be taken into account, when optimizing hemodialysis treatment for patients with diabetic nephropathy. A deeper understanding of these factors could lead to more personalized and effective treatment strategies, ultimately improving patient outcomes and enhancing their quality of life. Full article
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