Identification of Genetic and Epigenetic Factors in Male Infertility—2nd Edition (Closed)

Dear Colleagues,

The editors are grateful to the many researchers who contributed to the success of the first volume of this issue (https://www.mdpi.com/journal/life/special_issues/IWX810BS73). We are very pleased to announce the second volume of our Topical Collection “Identification of Genetic and Epigenetic Factors in Male Infertility—2nd Edition".

Male infertility affects approximately 7% men, as an economic, social and psychological burden for couples that seek biological parenthood all over the world. Despite the advances in technology and next-generation sequencing, which have contributed to the identification of novel genes underlying male infertility, its genetic causes are still often unknown. Spermatogenesis and fertilization involve complex processes with numerous pathways and interactions, for which the pathogenic mechanisms still need to be further investigated.

This Topical Collection aims to present a comprehensive collection of articles on the latest findings in the identification of genetic and epigenetic factors in male infertility, including genetic and epigenetic factors participating in different processes of proliferation and differentiation of spermatogonia, meiosis, spermiogenesis and sperm activation. In addition, we aim to uncover the essential roles they play and their pathogenic mechanisms, which could be helpful for patient prognosis. This collection will cover molecular, clinical research and translational medicine related to causative gene identification, epigenetic function discovery, assisted reproductive technology improvement, signaling pathways and interactions in male infertility.

We welcome original research articles and reviews, including, but not limited to, the following topics:

• Identification of causative genetic and epigenetic factors involved in male infertility.
• Translational medicine for male infertility through the application of identified associated factors.
• Classification or subclassification of patients according to the relevant pathways with detailed and precise phenotypes.
• Molecular function, crosstalk of signaling pathways, interaction with environments in processes of proliferation and differentiation of spermatogonia, meiosis, spermiogenesis and sperm activation.
• Assisted reproductive technology application and outcome of male infertility.

Dr. Weiyu Li
Collection Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• spermatogenesis
• male infertility
• next-generation sequencing
• assisted reproductive technology