Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Strategies for Controlling Synthetic Cells: Approaches, Models, Applications
edited by and
submission deadline 22 Apr 2025 | 1 articles | Viewed by 2943
Keywords: artificial cells; bioreactors; biosensor; cell-free systems; coacervates; controlled behavior; DNA signals; drug delivery; gene expression regulation; liposomes; microcompartments; modeling; molecular communication; nanomedicine; nanoparticles; optogenetics; polymersomes; protocells; signaling; stimulus-response; synthetic biology; synthetic cells
(This special issue belongs to the Section Synthetic Biology and Systems Biology)
Pathogenic Mechanisms, Diagnosis, and Treatment of Hypertension: Insights and Implications
edited by Shengyu Mu and Sankar Devarajan
submission deadline 25 Apr 2025 | 2 articles | Viewed by 3826 | Submission Open
Keywords: hypertension; cardiovascular disease; blood pressure; pathogenesis
(This special issue belongs to the Section Physiology and Pathology)
Origin of Life in Chemically Complex Messy Environments: 3rd Edition submission deadline 26 Apr 2025 | Viewed by 51 | Submission Open
Keywords: origin of life; complex chemical systems  ; prebiotic chemistry  ; prebiotic metabolisms  ; chemical evolution  ; prebiotic catalysts
(This special issue belongs to the Section Origin of Life)
Recent Insights in the Pathogenesis, Diagnosis, Prognosis and Treatment of Glomerular Disorders
edited by Adrian Constantin Covic and
submission deadline 29 Apr 2025 | 4 articles | Viewed by 2890 | Submission Open
Keywords: glomerular disorders; pathology; kidney biopsy; immunology; immunosuppresion; vasculitis
(This special issue belongs to the Section Medical Research)
Advances in Artificial Intelligence for Medical Image Analysis
edited by
submission deadline 30 Apr 2025 | 6 articles | Viewed by 13599 | Submission Open
Keywords: artificial intelligence; medical imaging; deep learning for medical imaging; histopathological image analysis; medical diagnosis; visualization in biomedical imaging; magnetic resonance imaging (MRI); X-ray computed tomography (CT); positron emission tomography (PET); medical image fusion
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases
edited by
submission deadline 30 Apr 2025 | 4 articles | Viewed by 6034 | Submission Open
Keywords: eye diseases; systemic diseases; oculomics; ocular imaging; eye surgery; retina; cornea; glaucoma; refractive surgery; OCT; OCTA
(This special issue belongs to the Section Medical Research)
Alkaloids: Extraction, Analysis and Function Research submission deadline 30 Apr 2025 | 2 articles | Viewed by 4562 | Submission Open
Keywords: alkaloids; biological activity; chemical profiling; structural elucidation; computational experiments
(This special issue belongs to the Section Plant Science)
AI and Precision Medicine: Using Machine Learning for Disease Diagnosis and Prediction
edited by and Sarantis Chlamydas
submission deadline 30 Apr 2025 | 3 articles | Viewed by 4474 | Submission Open
Keywords: AI; machine learning; cancer; cardiovascular diseases; neurological disorders; genomics; diagnosis; prognosis; treatment response; disease-risk prediction
(This special issue belongs to the Section Medical Research)
Advances in Brain-Machine Interfaces
edited by
submission deadline 30 Apr 2025 | 1 articles | Viewed by 4306 | Submission Open
Keywords: brain– machine interfaces; brain– computer interfaces; neurorehabilitation; neuroengineering; neurophysiology
(This special issue belongs to the Section Physiology and Pathology)
Pancreatic Cancer: Long Survivals
edited by Francesco Leonardi and
submission deadline 30 Apr 2025 | 1 articles | Viewed by 4183 | Submission Open
Keywords: pancreatic cancer; long survival; outcome; pancreatic adenocarcinoma; long-term survival; surgical resection; chemotherapy; NGS
(This special issue belongs to the Section Physiology and Pathology)
The Treatments for Cardiovascular Diseases submission deadline 30 Apr 2025 | 3 articles | Viewed by 3975 | Submission Open
Keywords: nitric oxide; hydrogen sulfide; reactive oxygen species; angiotensin; endothelin
(This special issue belongs to the Section Medical Research)
Novel Breakthroughs in Sepsis and Septic Shock Management
edited by and Vittorio Pavoni
submission deadline 30 Apr 2025 | 1 articles | Viewed by 2136 | Submission Open
Keywords: decatecholaminisation; non-amine-based therapy; beta blockers; hormone replacement; levosimendan; Angiotensin II; sepsis; septic shock; septic cardiomyopathy
(This special issue belongs to the Section Pharmaceutical Science)
G Protein-Coupled Receptors: Molecular Mechanisms Involved in Receptor Activation and Selectivity: Second Edition submission deadline 30 Apr 2025 | 1 articles | Viewed by 1752 | Submission Open
Keywords: G protein-coupled receptors; chemokines; dimerization; beta arrestin; biased agonist; pain; inflammation; neuroinflammation
(This special issue belongs to the Section Genetics and Genomics)
Molecular Mechanisms of Preeclampsia
edited by Feng Li
submission deadline 30 Apr 2025 | 1 articles | Viewed by 1574 | Submission Open
Keywords: preeclampsia; hypertension; proteinuria; placenta; fetal growth restriction; pregnancy com-plications; implantation
(This special issue belongs to the Section Reproductive and Developmental Biology)
Sleep and Sleep Disorders in Sports and Advanced Physical Exercise: 2nd Edition submission deadline 30 Apr 2025 | 1 articles | Viewed by 1349 | Submission Open
Keywords: sleep; sport; performance; physical exercise; sleep disorders; sleep regimens; fractured sleep; sleep at altitude; sleep medications
(This special issue belongs to the Section Physiology and Pathology)
From Muscle to Fascia: Current Trends and Future Perspectives submission deadline 30 Apr 2025 | 1 articles | Viewed by 1323 | Submission Open
Keywords: connective tissue; deep fascia; superficial fascia; retinacula; muscle stiffness; hyaluronan; densification; biomechanics; therapies
(This special issue belongs to the Section Physiology and Pathology)
Advances in Research in Biocatalysis: 2nd Edition
edited by and
submission deadline 30 Apr 2025 | 1 articles | Viewed by 1313 | Submission Open
Keywords: biochemical; biomedical; biomaterials; biocatalysis; biodegradation; biofuels; bioplastics; directed evolution of enzymes; environmental remediation
(This special issue belongs to the Section Biochemistry, Biophysics and Computational Biology)
New Perspectives and Innovations in Prosthetic Joint Infections
edited by Novella Cesta and
submission deadline 30 Apr 2025 | Viewed by 574 | Submission Open
Keywords: prosthetic joint infection; phage therapy; diagnostic tools in PJIs; antimicrobial resistance; biofilm-associated infections; antimicrobial therapy in PJIs; surgical outcomes; surgical management
(This special issue belongs to the Section Physiology and Pathology)
Gynecologic Oncology: Recent Advances and Future Perspectives
edited by Theodoros A. Panoskaltsis and
submission deadline 30 Apr 2025 | Viewed by 529 | Submission Open
Keywords: gynecologic cancer; gynecologic oncology; biomarkers in gynecology
(This special issue belongs to the Section Medical Research)
Innovations in Dairy Cattle Health and Nutrition Management
edited by Rasa Želvytė and Ingrida Monkevičienė
submission deadline 30 Apr 2025 | Viewed by 498 | Submission Open
Keywords: innovations; dairy cattle; health; nutrition; rumen; metabolism; biomarkers
(This special issue belongs to the Section Animal Science)
Innovations, Utilization, and Safety of Psychiatric Drugs: Current Trends and Future Directions
edited by Josipa Bukić
submission deadline 30 Apr 2025 | Viewed by 308 | Submission Open
Keywords: psychiatric diseases; psychiatric medicine; psychiatric pharmacotherapy; psychiatric drugs
(This special issue belongs to the Section Pharmaceutical Science)
Characterization, Bioactivity Evaluation and Utilization of Plant Polysaccharides
edited by and
submission deadline 30 Apr 2025 | Viewed by 272 | Submission Open
Keywords: plant polysaccharides; identification; characterization; functional property; biological activity; health benefit; food packaging
(This special issue belongs to the Section Pharmaceutical Science)
Multidisciplinary Approach for Diagnosis and Management of Cardiac Sarcoidosis—the Role of Multi-Centre Registry Development
edited by Vasileios Kouranos, Rakesh Sharma, Thomas Luescher and Khattar Rajdeep
submission deadline 30 Apr 2025 | Viewed by 210 | Submission Open
Keywords: cardiac sarcoidosis; registry; multidisciplinary
(This special issue belongs to the Section Physiology and Pathology)
Agri-Food Waste Extracts: Structural and Functional Characterization
edited by
submission deadline 30 Apr 2025 | Viewed by 209 | Submission Open
Keywords: agri-food waste; extracts; extraction techniques; chemical characterization; bioactivity; cytotoxicity and cytocompatibility; isolation of bioactive molecules
(This special issue belongs to the Section Plant Science)
Organogenesis and Regeneration: From Basic Research to Medical Study—2nd Edition
edited by , Junzheng Zhang and Ju Li
submission deadline 30 Apr 2025 | Viewed by 161 | Submission Open
Keywords: organogenesis; regeneration; development; proliferation; differentiation; blastema; signaling pathway
(This special issue belongs to the Section Reproductive and Developmental Biology)
Advances in Non-Invasive Brain Stimulation
edited by Mariagiovanna Cantone and
submission deadline 1 May 2025 | 2 articles | Viewed by 3255 | Submission Open
Keywords: translational neuroscience; clinical neurophysiology; neurodegeneration; neural plasticity; neurosonology; sleep disorders; cognitive decline; non-invasive brain stimulation; nutraceuticals; neurogenetics; transcranial magnetic stimulation; dementia; vascular cognitive impairment; stroke; depression; metaplasticity; motor cortex; motor learning; neurotrophins; transcranial-focused ultrasound
(This special issue belongs to the Section Medical Research)
Advances in the Biomedical Applications of Plants and Plant Extracts
edited by and Annamária Pallag
submission deadline 5 May 2025 | 18 articles | Viewed by 33866 | Submission Open
Keywords: herbals; plant extracts; polyphenols; anthocyanins; isolation; characterization; preparation; oxidative stress; apoptosis; inflammation; dermatitis; CNS; new target molecules
(This special issue belongs to the Section Pharmaceutical Science)
Obstructive Sleep Apnea and Related Disorders: Pathophysiological Traits and Strategies for Treatment
edited by
submission deadline 5 May 2025 | 9 articles | Viewed by 13140 | Submission Open
Keywords: obstructive sleep apnea; sleep fragmentation; cardiometabolic dysfunction; inflammation; co-morbidities
(This special issue belongs to the Section Physiology and Pathology)
Unravelling the Molecular Mechanisms of Different Stress Responses in Plants
edited by
submission deadline 9 May 2025 | 1 articles | Viewed by 876 | Submission Open
Keywords: biotic stresses; abiotic stresses; plant growth and development; crop productivity; molecular mechanisms
(This special issue belongs to the Section Plant Science)
MASLD and Its Comorbidities: From Epidemiology to Future Therapeutic Perspectives
edited by
submission deadline 9 May 2025 | Viewed by 237 | Submission Open
Keywords: MASLD and comorbidities/complications; diagnostic techniques and biomarkers; clinical trials; innovative therapies
(This special issue belongs to the Section Medical Research)
MASLD and Its Comorbidities: From Pathophysiology Perspectives
edited by
submission deadline 9 May 2025 | Viewed by 192 | Submission Open
Keywords: MASLD; integrative physiology; pathogenesis; biomarkers; translational research
(This special issue belongs to the Section Physiology and Pathology)
Ruminant Nutrition Strategies to Improve Feed Efficiency and Reduce Methane Emissions: 2nd Edition
edited by , Tongjun Guo and
submission deadline 15 May 2025 | Viewed by 290 | Submission Open
Keywords: ruminant nutrition; roughage utilization; unconventional feed materials; feed efficiency; production performance; methane emissions; feed additive
(This special issue belongs to the Section Animal Science)
Personalized Prevention and Treatment in Endocrinology, Diabetes and Metabolic Diseases
edited by Grigorios Panagiotou
submission deadline 16 May 2025 | 11 articles | Viewed by 21919 | Submission Open
Keywords: personalized medicine; precision prevention; multi-omics; obesity; diabetes and endocrinology
(This special issue belongs to the Section Medical Research)
Advances in Substance Abuse and Addiction
edited by , and Chieh-Liang Huang
submission deadline 16 May 2025 | 4 articles | Viewed by 6801 | Submission Open
Keywords: addiction medicine; opioid pharmacology; substance abuse; addictive disorders intervention
(This special issue belongs to the Section Pharmaceutical Science)
Innovations in Thoracic Surgery and Medicine: Advancements and Challenges
edited by Paolo Scanagatta
submission deadline 18 May 2025 | 4 articles | Viewed by 3938 | Submission Open
Keywords: thoracic medicine; thoracic surgery; lung cancer; artificial intelligence (AI); VATS; thoracic anesthesia; innovations
(This special issue belongs to the Section Medical Research)
Innovative Perspectives in Physical Therapy and Health submission deadline 22 May 2025 | 3 articles | Viewed by 3143 | Submission Open
Keywords: physical therapy; health; pain management; musculoskeletal disorders; ultrasonography; rehabilitation; innovative therapies
(This special issue belongs to the Section Medical Research)
Pain and Therapy: Historical Perspectives and Future Directions submission deadline 22 May 2025 | 3 articles | Viewed by 2684 | Submission Open
Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment
(This special issue belongs to the Section Medical Research)
Conservative Management of Chronic Disease
edited by
submission deadline 26 May 2025 | 5 articles | Viewed by 13314 | Submission Open
Keywords: chronic disease  ; conservative management; trial protocol; clinical research; interventions
(This special issue belongs to the Section Medical Research)
Effects of Exercise Training on Muscle Function
edited by Marco Duca and
submission deadline 26 May 2025 | 7 articles | Viewed by 12986 | Submission Open
Keywords: exercise; training; muscle function; resistance training; HIIT
(This special issue belongs to the Section Physiology and Pathology)
Feature Papers in Synthetic Biology and Systems Biology 2024
edited by
submission deadline 26 May 2025 | Viewed by 550 | Submission Open
Keywords: design and construction of synthetic biological systems; innovations in the creation of synthetic organisms; genetic circuits; and biomolecular devices; bottom-up synthetic biology; cell-free synthetic biology; tissue engineering and organoids; bioorthogonal parts; devices; systems; microcompartmentalized systems with soft or hard interfaces; theoretical considerations about synthetic biology; synthetic biology intersection with systems chemistry and bioorganic chemistry; computational modeling and simulation of biological processes; advances in computational tools and models that enhance our understanding of biological processes and systems; metabolic engineering and synthetic pathways; development of novel approaches for the production of biofuels; pharmaceuticals; and other valuable compounds; synthetic biology for approaching evolutionary problems; artificial evolution and in vitro evolution; optogenetics and related techniques; gene editing technologies; applications; and developments; education in synthetic and systems biology; cutting-edge techniques and applications of CRISPR and other gene editing tools; systems biology approaches to understanding complex biological networks; mathematical aspects of systems biology approaches; artificial photosynthesis; applications of synthetic biology in medicine; agriculture; and industry; practical applications of synthetic and systems biology in various sectors; including healthcare; agriculture; and industrial biotechnology; ethical; legal; and social implications of synthetic and systems biology; exploration of the broader implications of advancements in synthetic and systems biology; including ethical considerations and regulatory challenges and social implications
(This special issue belongs to the Section Synthetic Biology and Systems Biology)
Green Medicine: Unraveling the Medicinal Effects of Plant Extracts and Functional Foods submission deadline 28 May 2025 | 13 articles | Viewed by 18166 | Submission Open
Keywords: plant extracts; phytochemicals; inflammation; obesity; liver disease; oxidative stress; antioxidants; diabetes; skin damage; aging
(This special issue belongs to the Section Pharmaceutical Science)
New Updates in Adipocytes and Adipose Tissue: 2nd Edition submission deadline 30 May 2025 | 5 articles | Viewed by 15925 | Submission Open
Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines; insulin resistance
(This special issue belongs to the Section Physiology and Pathology)
Interdisciplinary Approach to Diabetes Mellitus: From Pathophysiology to Diagnosis and Therapeutic Challenges submission deadline 30 May 2025 | 7 articles | Viewed by 14321 | Submission Open
Keywords: cardiovascular disease; hyperlipidemia; neuropathy; nephropathy; retinopathy; skin conditions; impaired wound healing; hearing impairment; psychological effects; epigenetic imprinting; molecular profiling; biomarkers; targeted therapy; glucose control; conventional and complementary approaches; stem cell damage; vascular damage and regeneration; diabetes complications
(This special issue belongs to the Section Physiology and Pathology)
Bioactive Natural Compounds: Therapeutic Insights and Applications
edited by Vaidotas Žvikas
submission deadline 30 May 2025 | 7 articles | Viewed by 10131 | Submission Open
Keywords: medicinal plants; bioactive compounds; plant extracts; phytochemicals; analytical method validation
(This special issue belongs to the Section Pharmaceutical Science)
New Advances in Neuroimaging and Brain Functions: 2nd Edition submission deadline 30 May 2025 | 3 articles | Viewed by 9501 | Submission Open
Keywords: neuroimaging; brain functions; neurological diseases; humanities and social sciences; noninvasive methods; AI deep learning
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Fish Nutrition, Production, and Welfare
edited by Liviu-Dan Miron, , and
submission deadline 30 May 2025 | 4 articles | Viewed by 8991 | Submission Open
Keywords: aquaculture; fish nutrition; fish welfare; water quality; fish disease; feed additives; rearing systems; modern feeding technologies; waste management
(This special issue belongs to the Section Animal Science)
Applications of EEG in Neural Rehabilitation: 2nd Edition submission deadline 30 May 2025 | 2 articles | Viewed by 6110 | Submission Open
Keywords: neurorehabilitation; neuroplasticity; EEG; ERPs; qEEG; EEG mediated patient-therapist interaction; BCI; exoskeleton; cognitive rehabilitation; brain rewiring
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Pain Management and Related Complications in the Orthopedics and Neurology
edited by Danilo Donati and
submission deadline 30 May 2025 | 1 articles | Viewed by 2984 | Submission Open
Keywords: pain management of the upper and lower limb; pain management of the spine; orthopaedic rehabilitation; prevention of fall risks prevention and management infections; muscle; tendon; and joint diseases; neurological impacts on musculoskeletal health
(This special issue belongs to the Section Physiology and Pathology)
Human Infertility and Reproductive Endocrinology: 2nd Edition
edited by
submission deadline 30 May 2025 | 2 articles | Viewed by 2942 | Submission Open
Keywords: infertility; reproduction; reproductive endocrinology; male infertility; female infertility
(This special issue belongs to the Section Reproductive and Developmental Biology)
Microbial Diversity and Function in Aquatic Environments
edited by Xianglong Chen and
submission deadline 30 May 2025 | 1 articles | Viewed by 2070 | Submission Open
Keywords: aquatic environment; microbial diversity and function; element biogeochemical cycle; interaction between microorganisms and aquatic environments; metaomic approaches
(This special issue belongs to the Section Microbiology)
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