Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Knee Biomechanics—2nd Edition
edited by Jason Shearn
submission deadline 22 Jun 2026 | Viewed by 330 | Submission Open
Keywords: knee; tendon; ligament; injury; repair; healing; biomechanics; advanced techniques
(This special issue belongs to the Section Physiology and Pathology)
Reconstruction of Bone Defects submission deadline 23 Jun 2026 | 10 articles | Viewed by 15770 | Submission Open
Keywords: bone and fracture biomechanics; bone healing; critical size bone defects; fracture non-union; inflammation; joint arthroplasty and fracture osteosynthesis; implant designs; materials proprieties; patient selection; primary and revision settings
(This special issue belongs to the Section Medical Research)
Recent Advances in Vascular Biology and Chronic Kidney Disease (CKD)
edited by
submission deadline 26 Jun 2026 | 2 articles | Viewed by 10171 | Submission Open
Keywords: chronic kidney disease; vascular dysfunction; endothelial cells
(This special issue belongs to the Section Medical Research)
Advances in Anesthesia and Critical Care
edited by
submission deadline 26 Jun 2026 | 5 articles | Viewed by 10091 | Submission Open
Keywords: anesthesia; intensive care training; updates in anesthesia; machine learning
(This special issue belongs to the Section Medical Research)
Feature Papers in Medical Research: 4th Edition
edited by
submission deadline 26 Jun 2026 | 7 articles | Viewed by 7080 | Submission Open
Keywords: dermatological research; cancer research; cardiovascular research; general medicine; gastroenterological research; hematological research; immunological research; infectious diseases research; metabolism and endocrinology; nervous system research; nursing; pediatrics; pulmonary research; psychiatric research; rehabilitation; renal and urinary research; reproductive research and women's health; rheumatological research; skeletal and muscular research; vision research
(This special issue belongs to the Section Medical Research)
Advances in Dryland Agriculture Science
edited by and Hangyu Dong
submission deadline 26 Jun 2026 | 3 articles | Viewed by 5587 | Submission Open
Keywords: dry farming; climate smart agriculture; soil and water protection; conservation tillage; intercropping; crop rotation; saving irrigation
(This special issue belongs to the Section Plant Science)
Advanced Technologies and Clinical Practice of Cancer Radiotherapy
edited by
submission deadline 26 Jun 2026 | 1 articles | Viewed by 1540 | Submission Open
Keywords: proton therapy; BNCT; in vivo dose verification in radiotherapy; accelerators for radiation therapy; simulation of radiotherapies
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Innovations in Thoracic Medicine: Advancements and Challenges—2nd Edition
edited by Paolo Scanagatta
submission deadline 26 Jun 2026 | 1 articles | Viewed by 1217 | Submission Open
Keywords: thoracic medicine; lung cancer; artificial intelligence (AI); minimally invasive intervention; thoracic anesthesia; clinical innovation; technological advances
(This special issue belongs to the Section Medical Research)
Application of Mass Spectrometry-Based Multi-Omics in Biomedical Research submission deadline 26 Jun 2026 | 1 articles | Viewed by 885 | Submission Open
Keywords: mass spectrometry; multi-omics; proteomics; metabolomics; lipidomics; mass spectrometry imaging (MSI); biomarker discovery; translational research
(This special issue belongs to the Section Medical Research)
Harnessing Mitochondrial Rewiring for Cancer Therapy: Novel Strategies in the Era of Precision Medicine
edited by and Maria Sideridou
submission deadline 26 Jun 2026 | Viewed by 372 | Submission Open
Keywords: Oxidative stress; Metabolic rewiring; Carcinogenesis; DNA repair; Cancer therapy; Heteroplasmy
(This special issue belongs to the Section Physiology and Pathology)
Leveraging the Power of Enzymes in Biotechnological Applications
edited by
submission deadline 28 Jun 2026 | Viewed by 653 | Submission Open
Keywords: enzyme; 3D structure; function/activity; enzyme engineering; beneficial variants; industrial application
Effects of Exercise and Functional Interventions on Musculoskeletal Health
edited by
submission deadline 30 Jun 2026 | 11 articles | Viewed by 30193 | Submission Open
Keywords: musculoskeletal health; exercise; physical function; joint stability; fall prevention; rehabilitation science
(This special issue belongs to the Section Medical Research)
2nd Edition—Featured Papers on the Origins of Life
edited by James R. Lyons
submission deadline 30 Jun 2026 | 7 articles | Viewed by 28091 | Submission Open
Keywords: astrobiology; astrochemistry; planetary science; prebiotic chemistry; chirality; chemical evolution; protocells; synthetic biology; complex systems
(This special issue belongs to the Section Origins of Life)
The Emerging Role of Microbiota in Health and Diseases
edited by Edyta Juszczuk-Kubiak and Katarzyna Góralska
submission deadline 30 Jun 2026 | 7 articles | Viewed by 22349 | Submission Open
Keywords: microbiota; eubiosis; dysbiosis; microbiota– host interaction; microbiota– gut– brain axis; microbiome; bacteria– fungi interactions; microbiota modification; holobiont; cross-feeding; microbiota related diseases; microbiota functions
(This special issue belongs to the Section Microbiology)
Recent Advances in Physiotherapy for Musculoskeletal Disorders submission deadline 30 Jun 2026 | 7 articles | Viewed by 22264 | Submission Open
Keywords: musculoskeletal rehabilitation; emerging technologies; virtual reality; artificial intelligence; inflammatory genetics; physiotherapy; sports medicine; functional recovery
(This special issue belongs to the Section Physiology and Pathology)
Current Advances in Lung Cancer Diagnosis and Treatment
edited by , Daesik Yang and
submission deadline 30 Jun 2026 | 4 articles | Viewed by 13218 | Submission Open
Keywords: lung cancer; underlying lung disease; radiotherapy; systemic therapy; survival outcomes; complication; biomarkers
(This special issue belongs to the Section Medical Research)
Move to Thrive: Pioneering Health and Resilience Through Physical Activity submission deadline 30 Jun 2026 | 4 articles | Viewed by 7125 | Submission Open
Keywords: physical activity; inflammation modulation; chronic disease prevention; immune system adaptation; biomechanics; rehabilitation strategies; sports medicine; aging and physical activity; disability and movement; environmental and regional influences on exercise
(This special issue belongs to the Section Physiology and Pathology)
Advances in Livestock Breeding, Nutrition and Metabolism
edited by
submission deadline 30 Jun 2026 | 3 articles | Viewed by 6026 | Submission Open
Keywords: genetic selection; livestock breeding; genome editing; animal nutrition; precision feeding; nutritional additives; feed conversion; metabolism; animal health; sustainability
(This special issue belongs to the Section Animal Science)
Update on Microalgae Metabolites submission deadline 30 Jun 2026 | 2 articles | Viewed by 5231 | Submission Open
Keywords: biosynthesis; culture conditions; bioactive compounds; biological activity; biorefinery; proteins; peptides; antifreeze proteins; enzymes; carbohydrates; exocellular polysaccharides; carbohydrate-binding proteins; lipids; fatty acids; chlorophylls; carotenoids; phycobiliproteins; vitamins; minerals; trace elements; sterols; secondary metabolites; downstream processing; purification; safety; regulatory issues; clinical tests
(This special issue belongs to the Section Microbiology)
Musculoskeletal Imaging: Innovations in Diagnostics and Interventional Therapies
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 5112 | Submission Open
Keywords: magnetic resonance imaging; bone and bones; computed tomography; sarcoma; interventional radiology
(This special issue belongs to the Section Medical Research)
Latest Updates on Clinical Microbiology and Antimicrobial Resistant Infection
edited by Jun Sung Hong
submission deadline 30 Jun 2026 | 4 articles | Viewed by 4830 | Submission Open
Keywords: enterobacteriaceae; antimicrobial resistance; infection; health
(This special issue belongs to the Section Microbiology)
Microalgae and Their Biotechnological Potential
edited by , Yi Xin and Yuanxue Liang
submission deadline 30 Jun 2026 | 3 articles | Viewed by 4795 | Submission Open
Keywords: microalgae; biofuels; bioproducts; lipid metabolism; synthetic biology; system engineering
(This special issue belongs to the Section Microbiology)
Sialic Acid and Sialic Acid Derivatives in Biomedicine
edited by and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 4609 | Submission Open
Keywords: sialic acid; drug development; sialidase inhibitors; sialylation; sialidase; biomarker
(This special issue belongs to the Section Physiology and Pathology)
Role of Machine and Deep Learning in Drug Screening
edited by and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 3902 | Submission Open
Keywords: machine learning in drug screening; deep learning in drug discovery; virtual screening; molecular docking and dynamics; personalized medicine
(This special issue belongs to the Section Pharmaceutical Science)
Helicobacter pylori: 2nd Edition
edited by and
submission deadline 30 Jun 2026 | 3 articles | Viewed by 3876 | Submission Open
Keywords: H. pylori; cancers; antioxidative process; diagnostic methods
(This special issue belongs to the Section Microbiology)
Research on Gastrointestinal Cancer and Nutritional Health
edited by , Adam Mylonakis and Dimitrios Tsapralis
submission deadline 30 Jun 2026 | 2 articles | Viewed by 3542 | Submission Open
Keywords: dietary patterns; gastrointestinal cancer; clinical nutrition; nutritional status; nutritional assessment; metabolism; gastric cancer; esophageal cancer; pancreatic cancer; colorectal cancer
(This special issue belongs to the Section Medical Research)
Pathological and Clinical Updates on Eye Diseases
edited by Pier Luigi Surico and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 3418 | Submission Open
Keywords: ophthalmology; eye diseases; gene therapy; ocular surface; ocular immunology; cornea
(This special issue belongs to the Section Medical Research)
Perspectives on Nutrition and Livestock Health
edited by , Yan Wang and
submission deadline 30 Jun 2026 | 4 articles | Viewed by 3256 | Submission Open
Keywords: nutrition; animal health; animal reproductive; animal welfare; gut microbiome
(This special issue belongs to the Section Animal Science)
New Advances in the Treatment and Assessment of Temporomandibular Joint Disorders submission deadline 30 Jun 2026 | 3 articles | Viewed by 3044 | Submission Open
Keywords: orofacial dysfunction; multifactorial etiology; advanced diagnostic technologies; biomechanical modeling of TMJ; novel imaging techniques; inflammatory and degenerative changes; interdisciplinary management; conservative therapy approaches; occlusal concepts; splint therapy design; physical therapy regimens; long-term implant treatment outcomes; personalized treatment strategies
(This special issue belongs to the Section Medical Research)
Advances in the Glyoxalase Pathway: Implications for Oxidative Stress Management in Cancer Therapy and in Age-Related Disease submission deadline 30 Jun 2026 | 2 articles | Viewed by 2751 | Submission Open
Keywords: glyoxalase system; methylglyoxal; advanced glycation end-products; dicarbonyl stress; oxidative stress; age-related disease; cancer
(This special issue belongs to the Section Physiology and Pathology)
Cranial Base Tumors: Pathogenesis, Diagnosis, and Treatments
edited by and Marcin Szymański
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2659 | Submission Open
Keywords: skull base tumors; neuro-oncology; endoscopic surgery; cranial nerve preservation; AI-assisted diagnostics; multidisciplinary management
(This special issue belongs to the Section Medical Research)
Channel Proteins and Transporters in Human Health and Disease submission deadline 30 Jun 2026 | 2 articles | Viewed by 2533 | Submission Open
Keywords: channel proteins; transporters; ion channel
(This special issue belongs to the Section Genomics and Proteomics)
Post-Concussion Syndrome and Functional Neurological Disorder submission deadline 30 Jun 2026 | 2 articles | Viewed by 2213 | Submission Open
Keywords: post-concussion syndrome; functional neurological disorder; mild traumatic brain injury; cognitive dysfunction  ; neuroimaging; biomarkers; neurorehabilitation
(This special issue belongs to the Section Medical Research)
Neuroimaging and Integrative Analyses in Psychiatry and Addictive Disorders
edited by Arkadiusz Komorowski
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2149 | Submission Open
Keywords: psychiatry; neuroimaging; forensic psychiatry; fMRI; PET; EEG; addiction; substance use disorders (SUD); psychotherapy; treatment-resistant depression (TRD); attention deficit hyperactivity disorder (ADHD)
(This special issue belongs to the Section Physiology and Pathology)
Applications of Dermatoscopy in Skin Diseases: 2nd Edition submission deadline 30 Jun 2026 | 1 articles | Viewed by 2065 | Submission Open
Keywords: melanoma; skin cancer; inflammoscopy; trichoscopy; ultraviolet reflectance dermatoscopy; skin of color; basal cell carcinoma; squamous cell carcinoma; nevus; digital dermoscopy
(This special issue belongs to the Section Medical Research)
Update on Obstructive Sleep Apnea (OSA) submission deadline 30 Jun 2026 | 2 articles | Viewed by 1806 | Submission Open
Keywords: obstructive sleep apnea; snoring; sleep-disordered breathing; adult sleep apnea; pediatric sleep apnea
(This special issue belongs to the Section Physiology and Pathology)
Vector-Borne Diseases and One Health
edited by , Shayenne Silva and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1704 | Submission Open
Keywords: vector-borne diseases; One Health; malaria; dengue; Zika; chikungunya; yellow fever; West Nile virus; Lyme disease; leishmaniasis; Chagas
(This special issue belongs to the Section Animal Science)
Physical Rehabilitation for Musculoskeletal Disorders: 2nd Edition
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1680 | Submission Open
Keywords: physical rehabilitation; musculoskeletal disorders; pain management; range of motion; muscle strengthening; mobility enhancement; physical therapy; manual therapy; AI in rehabilitation
(This special issue belongs to the Section Medical Research)
Transplant Medicine: Updates and Current Challenges
edited by Phillipe Abreu
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1656 | Submission Open
Keywords: robotic transplantation; organ transplants; transplant oncology
(This special issue belongs to the Section Medical Research)
Autoimmune Disorders: From Pathophysiology to Therapeutics
edited by and Chiara Mura
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1534 | Submission Open
Keywords: autoimmunity; autoimmune diseases; polyglandular autoimmune syndromes; thyroid autoimmune disease; type 1 diabetes
(This special issue belongs to the Section Physiology and Pathology)
Drug Safety and Outcomes in Respiratory and Critical Care Medicine
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1321 | Submission Open
Keywords: drug safety; adverse drug reactions; pharmacovigilance; critical care medicine; respiratory diseases; clinical outcomes; intensive care pharmacotherapy; drug– drug interactions
(This special issue belongs to the Section Pharmaceutical Science)
Transformative Technologies in Liver Transplantation submission deadline 30 Jun 2026 | 1 articles | Viewed by 1315 | Submission Open
Keywords: liver; transplant; liver surgery; machine perfusion; radiomics; nanotechnology; 3D printing; gene editing
Impact of Environmental Factors on the Diversity and Structure of Bacterial and Eukaryotic Communities
edited by and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1314 | Submission Open
Keywords: environmental factors; bacterial and eukaryotic communities; climate adaptation; pollution; microbial resilience; metagenomic analysis; amplicon sequencing; bioinformatics
(This special issue belongs to the Section Microbiology)
Cutting-Edge Research in Rhinology and Allergy: Unraveling Disease Mechanisms and Treatment Innovations
edited by Min-Seok Rha
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1296 | Submission Open
Keywords: rhinology; allergy; chronic rhinosinusitis; allergic rhinitis; asthma; precision medicine; clinical immunology; immunopathology; therapeutic innovation
Comprehensive Treatment and Precision Medicine Strategies for Heart Disease
edited by Serge Sicouri
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1260 | Submission Open
Keywords: precision medicine; artificial intelligence; risk stratification; machine learning; translational research; cardiovascular outcomes
(This special issue belongs to the Section Medical Research)
Advances and Challenges in Urothelial and Prostate Cancer: Toward Precision Urologic Oncology
edited by Sashi S. Kommu
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1210 | Submission Open
Keywords: urothelial carcinoma; prostate cancer; immunotherapy; genomics and biomarkers; precision imaging (PSMA PET; mpMRI); targeted therapies (PARP; FGFR; DDR); focal therapy and theranostics; tumour microenvironment; quality of life and survivorship; health disparities in cancer care; artificial intelligence
(This special issue belongs to the Section Medical Research)
Sleep-Disordered Breathing: Key Pathophysiological Mechanisms and Their Clinical Implications
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 945 | Submission Open
Keywords: sleep-disordered breathing; sleep fragmentation; inflammation; cardiovascular disease; insulin resistance
(This special issue belongs to the Section Physiology and Pathology)
Extracellular Vesicles: Biology, Mechanisms, and Therapies for Cerebrovascular Disorders
edited by Jinju Wang
submission deadline 30 Jun 2026 | 1 articles | Viewed by 693 | Submission Open
Keywords: extracellular vesicles; cerebrovascular disorders; dementia; extracellular vesicle-based therapy
(This special issue belongs to the Section Physiology and Pathology)
“Out-of-the-Organics-Box” Reflections On and Scenarios for Life’s Emergence
edited by
submission deadline 30 Jun 2026 | Viewed by 474 | Submission Open
Keywords: emergence of life; thermodynamics; bioenergetics; information theory; early metabolism; metal ions in biochemistry
(This special issue belongs to the Section Origins of Life)
Placental Spectrum Disorders and Gynecological Oncology
edited by Gianluca Raffaello Damiani
submission deadline 30 Jun 2026 | Viewed by 308 | Submission Open
Keywords: placenta; trophoblastic tumor; mola; tumors; bleeding
(This special issue belongs to the Section Medical Research)
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