Advances in the Immunological Cross Talk between Mother and Fetus
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Reproductive and Developmental Biology".
Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 183
Special Issue Editors
Interests: antioxidants; inflammation; immunology; pregnancy; maternal and fetal health; anatomy and physiology; medicine
Interests: maternal and fetal medicine; maternal nutrition; maternal diabetes; maternal obesity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleague,
Recent research has made significant strides in unravelling the complex and intricate immunological communication between a mother and her developing fetus. The immune system plays a crucial role in maintaining pregnancy and protecting the fetus from potential threats while accommodating the semi-allogeneic nature of the developing conceptus.
Studies have elucidated the mechanisms by which the maternal immune system tolerates fetal antigens, preventing rejection while maintaining immune surveillance against pathogens. Moreover, recent research has shed light on the impact of maternal factors, such as microbiota and maternal infections, on fetal immune development and programming.
Advances in technology, such as single-cell sequencing and high-resolution imaging, have enabled the characterization of immune cell populations and their spatial distribution within the maternal–fetal interface. Furthermore, these breakthroughs have allowed for the identification of novel immune checkpoints and signaling pathways involved in maternal–fetal immune interactions.
This growing body of knowledge holds great promise for improving our understanding of pregnancy complications, including preterm birth, preeclampsia, and fetal growth restriction. Ultimately, these advances may pave the way for the development of innovative therapeutic strategies to ensure the health and well-being of both mother and fetus.
This Special Issue brings together and highlights key advancements in our understanding of this unique and fascinating immunological cross talk.
Dr. Gareth A. Nye
Dr. José Luis Bartha
Guest Editor
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Keywords
- pregnancy
- immunology
- immune
- fetal
- maternal
- cross talk
- developmental origins of health and disease
- breast milk
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