The Multifaceted Role of B Cells in the Pathogenesis of Rheumatic Diseases
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Cell Biology and Tissue Engineering".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 85
Special Issue Editor
Special Issue Information
Dear Colleagues,
Recently, we set up a Special Issue which will focus on the multifaceted role of B cells in the pathogenesis of rheumatic diseases. Autoantibodies are a hallmark of rheumatic diseases with the presence of anticitrullinated protein autoantibodies (ACPA) predating the onset of rheumatoid arthritis by up to 10 years. Recent studies demonstrate cross reactivity of antigen-specific B cells characterized by a high expression of CXCR3. We and others have recently shown that CXCR3 expressing B cells adapt to the hypoxic conditions of the inflamed joint and are capable of T cell costimulation, proinflammatory cytokine production and immune cell recruitment. With both autoantibody-positive and autoantibody-negative patients with RA benefiting from B cell depletion, understanding the role of B cells in the pathogenesis of arthritis could generate significant benefits for the patients. The rise of RNAseq approaches for the characterization of the synovial cell atlas has generated an opportunity to investigate the role of B cells in the pathogenesis of arthritis, beyond the production of autoantibodies, and to identify novel therapies for targeted intervention. This Special Issue aims to “reignite” the scientific interest and focus on key contributors of inflammation in arthritis.
The Special Issue is now open for submissions. Prospective authors should first send a short abstract or tentative title to the Editorial Office. If the Editors deem the topic to be appropriate for inclusion in this Special Issue, the author will be encouraged to submit a full manuscript.
Dr. Achilleas Floudas
Guest Editor
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Keywords
- B cells
- antibodies
- arthritis
- RNAseq
- ACPA
- RF
- antigen-specific
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