The Biology and Functions of Platelets: Emerging Challenges
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 26
Special Issue Editors
2. University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA
Interests: transfusion; apheresis; platelets; hematopoiesis, alloimmunization; cell therapies; sickle cell disease; thrombocytopenia; thrombotic thrombocytopenic purpura; thrombotic microangiopathies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Platelets have long been known to be at the center of hemostatic regulation in the body. Low platelet counts and dysfunctional platelets can often lead to hemorrhage, while hyperactive platelets can have the opposite effect and result in thrombosis or embolization. However, platelets have several known non-hemostatic functions that are essential to maintaining homeostasis. For example, they play important roles in the immune response not only through their phagocytosis of microorganisms but also through the release of stored immune mediators that affect how other cells respond to infection. Along these lines, platelet transfusions can themselves affect the recipient’s immune response through the process of transfusion-related immunomodulation. It is through their myriad of receptors and stored mediators that platelets influence cells and organ systems as a whole. It is with this in mind that this Special Issue seeks to showcase reports describing the important functions carried out by platelets. Original research describing in vitro and in vivo models of platelet functions are welcome. Similarly, platelet-centric diseases and reports describing platelet defects through experimentation are encouraged. Pathologic mediators affecting platelets and reports looking at effects of new therapeutic approaches on platelets are similarly welcomed. Major comprehensive reviews showcasing the functions of platelets beyond hemostasis are also encouraged. Even though we do not encourage submission of case reports, we will welcome them if they are in the context of a thorough review of the area covered by this Special Issue.
Dr. Robert Maitta
Dr. Mirian Andrea Duque
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- platelet
- hemostasis
- toll-like receptor
- immunity
- phagocytosis
- transfusions
- von Willebrand factor
- thrombocyte
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
