Endocrine Mechanisms and Cellular Dynamics in Obesity: Insights and Innovations
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 43
Special Issue Editors
Interests: metabolism; obesity; diabetes; hepatology; gastrointestinal peptides; biological rhythms; non-coding RNAs; glucocorticoids
Special Issue Information
Dear Colleagues,
Obesity is a metabolic disorder characterized by excessive nutrient intake and adipose tissue mass expansion. It is associated with a number of life-threatening comorbidities. Despite major advances over the past decades, our understanding of the hormonal and molecular mechanisms driving obesity, as well as the alterations associated with it, is far from being complete. The identification of leptin, an adipokine hormone which serves as a link between the adipose tissue and the brain providing information about the availability of fat stores in the body, and which regulates food intake and energy expenditure, represented a seminal finding for the field.
This year, we celebrate the 30th anniversary of the discovery of leptin, and we would like to commemorate such a landmark with a Special Issue on “Endocrine Mechanisms and Cellular Dynamics in Obesity: Insights and Innovations”. In this Issue, we welcome original research articles and cutting-edge reviews on the following topics:
- Adipokines and other peripheral signals (such as gastrointestinal peptides) involved in the regulation of food intake.
- Cellular physiology and molecular characterization of the hypothalamic neurons implicated in the regulation of appetite.
- Cellular physiology and molecular characterization of both healthy and obese adipocyte.
- Alterations in glucose and lipid homeostasis induced by obesity.
- Role of inflammation in the metabolic alterations induced by obesity.
- Deregulation of hormonal axes in the context of obesity: hyperinsulinemia, hyperleptinemia, changes in sexual hormones, defective growth hormone secretion, local hyperactivity of glucocorticoids, etc.
- Molecular mechanisms of insulin and leptin resistance.
- Changes in the physiology and cellular dynamics of tissues particularly affected by obesity, such as liver and pancreatic islets.
- Hormone-based novel therapies for the treatment of obesity.
Dr. Manuel Gil Lozano
Dr. Marina Romaní-Pérez
Guest Editors
Manuscript Submission Information
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Keywords
- gastrointestinal peptides
- adipokines
- food intake regulation
- hypothalamus
- orexigenic
- anorexigenic
- adipocytes
- pancreatic islets
- leptin
- insulin
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