Natural Compounds in Cancer Therapy
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Pharmaceutical Science".
Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 479
Special Issue Editor
Interests: synthesis; isolation; natural compounds; UV protection; cosmetics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer still remains the second leading cause of death, and most of the drugs (60%) currently in use for primary prevention of cancer (chemoprevention) are accomplished or inspired by phytochemicals.
Therefore, research on natural products is still a valuable approach to compounds with unique structures and mechanisms of action. Some of them, previously not used because of lack of selectivity, have been brought back from oblivion via conjugation with monoclonal antibodies.
Phytochemicals are involved in the prevention and reversal of the carcinogenic process through multiple signal transduction pathways: inhibiting the ROS producion, NF-κB activation, angiogenesis, AP-1 and COX-2, regulating Stat3 and MAPKs pathways, and inducing cell cycle arrest and apoptosis.
Some examples of such phytochemicals are curcumin, epigallocatechin gallate, lycopene, indole-3-carbinol, compounds from cruciferous vegetables and garlic, gingerol, folate, and resveratrol.
Additional chemopreventive agents include retinol, vitamin D analogues, apigenin, quercetin, ursolic acid and genistein, daidzein, and glycitein.
Therefore, there are plenty of opportunities for research in this field.
Prof. Stefano Manfredini
Guest Editor
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Keywords
- chemoprevention
- natural products drug sources
- phytochemicals
- antioxidants
- pathway
- anticancer
- natural compounds
- signaling
- cancer therapy
- drug discovery
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