Advances in Magnetic Nanoparticles: Biocompatibility, Toxicity, and Biomedical Applications

A special issue of Magnetochemistry (ISSN 2312-7481). This special issue belongs to the section "Applications of Magnetism and Magnetic Materials".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 41

Special Issue Editor

Special Issue Information

Dear Colleagues,

Magnetic nanoparticles (MNPs) have great potential in various areas such as medicine, cancer therapy and diagnostics, biosensing, and material science.

With the development of nanotechnology, the emergence of novel antitumor techniques that utilize magnetic nanoparticles (MNPs) such as magnetic hyperthermia and magnetomechanical stress have been the subject of much attention and study in recent years as anticancer tools. In magnetic hyperthermia, an external alternating magnetic field is used to heat the area of the cancer tissue due to the local heating of the magnetic nanoparticles, which are preferentially accumulated in cancer cells due to altered iron metabolism. This treatment leads to cellular effects such as decreased cell viability, cytoskeleton damage, the elevation of oxidative stress, cell cycle arrest, and cellular death by apoptosis. By taking advantage of differences in the thermal resistance of normal and tumor cells, magnetic hyperthermia can kill tumor cells selectively, thus lowering the side effects.

In this Special Issue, special attention will be paid to the utilization of strategies for the functionalization of MNPs in order to improve their biocompatibility and to direct their application by binding biofunctional molecules such as antibodies, ligands, or receptors; this will provide high selectivity and sensitivity for many biological applications.  

A relatively novel technique whose popularity has soared in recent years for the treatment of cancer is magnetomechanical stress. In this technique, the magnetic field exerts magnetic forces on the magnetic nanoparticles; in turn, this exerts mechanical forces on malignant and non-malignant cell membranes, causing damage and cell death primarily to cancerous tissues.

This Special Issue will focus on current approaches to the use of magnetic nanoparticles, magnetic hyperthermia, and magnetomechanical stress in the search for a multifunctional therapy in cancer, with an improved therapeutic index for treatment without the occurrence of non-additive side effects in normal tissue.

Prof. Dr. Rumiana Tzoneva
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Magnetochemistry is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnetic nanoparticles
  • biocompatibility
  • magnetic hyperthermia
  • magnetomechanical stress
  • cancer cells
  • cell death
  • cytoskeleton damage
  • cell cycle arres
  • oxidative stress

Published Papers

This special issue is now open for submission.
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