Marine Bioactive Compound Discovery Through OSMAC Approach—2nd Edition
A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 284
Special Issue Editor
Interests: marine microorganisms; secondary metabolites; anticancer; action mechanism; biosynthetic pathway
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Marine microorganisms represent a treasure trove of structurally diverse natural products with significant bioactivities. The OSMAC (One Strain Many Compounds) strategy has emerged as a revolutionary tool in the field of natural product discovery due to its powerful ability to efficiently mine microbial secondary metabolites.
This Special Issue aims to bring together global research efforts in order to showcase the latest breakthroughs, innovative methodologies, and profound insights regarding the application of the OSMAC strategy in discovering novel and highly bioactive natural products. We focus on how the ingenious manipulation of cultivation conditions—such as medium composition, physical parameters, co-cultivation, and the addition of small molecule elicitors—can activate silent biosynthetic gene clusters (BGCs) in microorganisms, thereby significantly expanding the accessible chemical space.
We sincerely invite experts and scholars from the fields of natural products chemistry, microbiology, synthetic biology, drug discovery, bioinformatics, fermentation engineering, and related interdisciplinary areas to contribute original research articles and high-quality reviews. By compiling cutting-edge achievements in this field, this Special Issue seeks to deepen the understanding of microbial chemical diversity; propel theoretical innovation and technological advancement of the OSMAC strategy; accelerate the discovery process of novel natural products with important bioactivities; and provide a new fountainhead of innovation for drug research and development, agriculture, and industrial biotechnology.
We look forward to receiving your contributions.
Prof. Dr. Xiaoling Lu
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- marine microorganisms
- secondary metabolites
- OSMAC
- epigenetic
- cryptic
- bioactivity
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