Marine Streptomyces-Derived Natural Products 2024

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Structural Studies on Marine Natural Products".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 3361

Special Issue Editors


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Guest Editor
Department of Chemistry and Nano Science, College of Natural Sciences, Ewha Womans University, Seodaemun-gu, Seoul 120-750, Republic of Korea
Interests: marine natural prodcuts; structure elucidation of natural products; antibacteiral and anti-cancer natural products
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Guest Editor
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea
Interests: marine actinomycetes; natural products; NMR; structure elucidation; antibiotics; symbiosis; biosynthesis; genomics
Special Issues, Collections and Topics in MDPI journals
Ocean Science & Technology School, Korea Maritime and Ocean University, Busan 49112, Republic of Korea
Interests: bioactivity natural product; chemistry; chromatography; medicinal and pharmaceutical chemistry; phytochemicals; extraction; antimicrobials; antioxidant activity

Special Issue Information

Dear Colleagues,

It is widely acknowledged that marine microorganisms possess considerable potential as sources of bioactive natural products. Streptomyces, a principal subdivision of Actinobacteria, has been the subject of extensive investigation for its novel secondary metabolites. This fertile microbial genus accounts for over 80% of actinomycete natural products and approximately 50% of all known antibiotics.

Therefore, Streptomyces strains derived from marine-related environments require attention from researchers. More specifically, the most recent advanced approaches demand a thorough examination, such as an isolation strategy for the bioactive metabolites producing Streptomyces strains, applications of the metabolites based on their wide range of bioactivities, and the chemical structure elucidation of marine microbial secondary metabolites. This Special Issue is dedicated to studying the inherent potential of these microorganisms as an abundant reservoir of marine natural products.

Dr. Sang-Jip Nam
Dr. Dong-Chan Oh
Dr. Inho Yang
Guest Editors

Manuscript Submission Information

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Keywords

  • marine streptomyces
  • marine natural product
  • chemical structure elucidation
  • bioactive secondary metabolite
  • drug hit/lead discovery

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Published Papers (2 papers)

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Research

11 pages, 1552 KiB  
Article
Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from Streptomyces sp. MS751
by Jiaming Yu, Hui Guo, Jing Zhang, Jiansen Hu, Hongtao He, Caixia Chen, Na Yang, Fan Yang, Zexu Lin, Huanqin Dai, Liming Ouyang, Cuihua Liu, Xiaoguang Lei, Lixin Zhang, Guoliang Zhu and Fuhang Song
Mar. Drugs 2024, 22(6), 259; https://doi.org/10.3390/md22060259 - 3 Jun 2024
Viewed by 873
Abstract
A new dimeric C-glycoside polyketide chrysomycin F (1), along with four new monomeric compounds, chrysomycins G (2), H (3), I (4), J (5), as well as three known analogues, chrysomycins A (6 [...] Read more.
A new dimeric C-glycoside polyketide chrysomycin F (1), along with four new monomeric compounds, chrysomycins G (2), H (3), I (4), J (5), as well as three known analogues, chrysomycins A (6), B (7), and C (8), were isolated and characterised from a strain of Streptomyces sp. obtained from a sediment sample collected from the South China Sea. Their structures were determined by detailed spectroscopic analysis. Chrysomycin F contains two diastereomers, whose structures were further elucidated by a biomimetic [2 + 2] photodimerisation of chrysomycin A. Chrysomycins B and C showed potent anti-tuberculosis activity against both wild-type Mycobacterium tuberculosis and a number of clinically isolated MDR M. tuberculosis strains. Full article
(This article belongs to the Special Issue Marine Streptomyces-Derived Natural Products 2024)
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13 pages, 4201 KiB  
Article
Anithiactin D, a Phenylthiazole Natural Product from Mudflat-Derived Streptomyces sp., Suppresses Motility of Cancer Cells
by Sultan Pulat, Inho Yang, Jihye Lee, Sunghoon Hwang, Rui Zhou, Chathurika D. B. Gamage, Mücahit Varlı, İsa Taş, Yi Yang, So-Yeon Park, Ahreum Hong, Jeong-Hyeon Kim, Dong-Chan Oh, Hangun Kim, Sang-Jip Nam and Heonjoong Kang
Mar. Drugs 2024, 22(2), 88; https://doi.org/10.3390/md22020088 - 14 Feb 2024
Cited by 1 | Viewed by 2117
Abstract
Anithiactin D (1), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes Streptomyces sp. 10A085. The chemical structure of 1 was elucidated based on the interpretation of NMR and MS data. The absolute configuration of 1 was determined [...] Read more.
Anithiactin D (1), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes Streptomyces sp. 10A085. The chemical structure of 1 was elucidated based on the interpretation of NMR and MS data. The absolute configuration of 1 was determined by comparing the experimental and calculated electronic circular dichroism (ECD) spectral data. Anithiactin D (1) significantly decreased cancer cell migration and invasion activities at a concentration of 5 μM via downregulation of the epithelial-to-mesenchymal transition (EMT) markers in A549, AGS, and Caco-2 cell lines. Moreover, 1 inhibited the activity of Rho GTPases, including Rac1 and RhoA in the A549 cell line, suppressed RhoA in AGS and Caco-2 cell lines, and decreased the mRNA expression levels of some matrix metalloproteinases (MMPs) in AGS and Caco-2 cell lines. Thus 1, which is a new entity of the 2-phenylthiazole class of natural products with a unique aniline-indole fused moiety, is a potent inhibitor of the motility of cancer cells. Full article
(This article belongs to the Special Issue Marine Streptomyces-Derived Natural Products 2024)
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