Immunomodulatory Activities of Marine Products

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1530

Special Issue Editor


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Guest Editor
Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung, Republic of Korea
Interests: the functional materials from marine organisms; the functional marine lipids and fatty acids; immune regulation and anti-inflammation; eicosanoid and immune regulation

Special Issue Information

Dear Colleagues,

Homeostasis for the immune system is critical to maintaining cellular processes, and diverse bio-functional materials have been developed for human physiology associated with immunity. Immune cells such as macrophages and NK cells prevent host infection and erase cancer cells, correlated with immune regulation in cancer therapy. Immune-associated organs like the spleen and thymus include immune cells such as monocytes and macrophages with B and T lymphocyte cells for immune modulation, and the immune biomarkers show the immune status.

Recently, marine natural products have received considerable attention because of their bio-functional activity for immune regulation, and a variety of marine sources such as starfish, seaweed, sea cucumber, and sea squirt have been researched to modulate immune systems and to protect against many chronic diseases and physiological problems for human health.

Dr. Woo Jung Park
Guest Editor

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Keywords

  • marine natural products
  • immune modulation/regulation
  • biological activity
  • immune function
  • functional marine materials
  • marine extracts
  • marine organisms
  • anti-inflammation
  • physiological regulation
  • human immune health

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Published Papers (1 paper)

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Research

14 pages, 8504 KiB  
Article
Lipids Extracted from Aptocyclus ventricosus Eggs Possess Immunoregulatory Effects on RAW264.7 Cells by Activating the MAPK and NF-κB Signaling Pathways
by Seul Gi Lee, Weerawan Rod-in, Jun Jae Jung, Seok Kyu Jung, Sang-min Lee and Woo Jung Park
Mar. Drugs 2024, 22(8), 368; https://doi.org/10.3390/md22080368 - 13 Aug 2024
Viewed by 1258
Abstract
This study was conducted to evaluate the potential anti-inflammatory and immune-enhancement properties of lipids derived from Aptocyclus ventricosus eggs on RAW264.7 cells. Firstly, we determined the fatty acid compositions of A. ventricosus lipids by performing gas chromatography analysis. The results showed that A. [...] Read more.
This study was conducted to evaluate the potential anti-inflammatory and immune-enhancement properties of lipids derived from Aptocyclus ventricosus eggs on RAW264.7 cells. Firstly, we determined the fatty acid compositions of A. ventricosus lipids by performing gas chromatography analysis. The results showed that A. ventricosus lipids contained saturated fatty acids (24.37%), monounsaturated fatty acids (20.90%), and polyunsaturated fatty acids (54.73%). They also contained notably high levels of DHA (25.91%) and EPA (22.05%) among the total fatty acids. Our results for the immune-associated biomarkers showed that A. ventricosus lipids had immune-enhancing effects on RAW264.7 cells. At the maximum dose of 300 µg/mL, A. ventricosus lipids generated NO (119.53%) and showed greater phagocytosis (63.69%) ability as compared with untreated cells. A. ventricosus lipids also upregulated the expression of iNOS, IL-1β, IL-6, and TNF-α genes and effectively upregulated the phosphorylation of MAPK (JNK, p38, and ERK) and NF-κB p65, indicating that these lipids could activate the MAPK and NF-κB pathways to stimulate macrophages in the immune system. Besides their immune-enhancing abilities, A. ventricosus lipids significantly inhibited LPS-induced RAW264.7 inflammatory responses via the NF-κB and MAPK pathways. The results indicated that these lipids significantly reduced LPS-induced NO production, showing a decrease from 86.95% to 38.89%. Additionally, these lipids downregulated the expression of genes associated with the immune response and strongly suppressed the CD86 molecule on the cell surface, which reduced from 39.25% to 33.80%. Collectively, these findings imply that lipids extracted from A. ventricosus eggs might have biological immunoregulatory effects. Thus, they might be considered promising immunomodulatory drugs and functional foods. Full article
(This article belongs to the Special Issue Immunomodulatory Activities of Marine Products)
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